Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D3-creatine dilution method

Journal of Cachexia, Sarcopenia and Muscle

Volumn 4, Issue 3, 2013, Pages 217-223

  Stimpson, Stephen A ^a   Leonard, Michael S ^a   Clifton, Lisa G ^a   Poole, James C ^a   Turner, Scott M ^b   Shearer, Todd W ^a   Remlinger, Katja S ^a   Clark, Richard V ^a   Hellerstein, Marc K ^b,c   Evans, William J ^a  

^a GLAXOSMITHKLINE   (United States)

^b KINEMED INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Body composition; Stable isotope dilution; Total body creatine pool size; Total body skeletal muscle mass

Indexed keywords

CREATINE; CREATININE; D 3 CREATINE; D 3 CREATININE; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; CREATININE URINE LEVEL; DILUTION; LEAN BODY WEIGHT; LIQUID CHROMATOGRAPHY; LONGITUDINAL STUDY; MALE; MEASUREMENT ACCURACY; MUSCLE MASS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; STEADY STATE; TANDEM MASS SPECTROMETRY; TURNOVER TIME; URINE LEVEL;

EID: 84884548263     PISSN: 21905991     EISSN: 21906009     Source Type: Journal    
DOI: 10.1007/s13539-013-0110-1     Document Type: Article

References (12)

1. Heymsfield SB, Arteaga C, McManus BS, Smith J, Moffitt S. Measurement of muscle mass in humans: validity of the 24-h urinary creatinine method. Am J Clin Nutr. 1983;37: 478-94.
2. Hunter A. The biological distribution of creatine and creatinine. Creatine and creatinine. London: Longmans, Green and Co. LTD; 1928.
3. Walker JB. Creatine: biosynthesis, regulation, and function. Adv Enzymol Relat Areas Mol Biol. 1979;50: 177-242.
4. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000;80: 1107-213.
5. Stimpson SA, Turner SM, Clifton LG, Poole JC, Mohammed HA, Shearer TW, et al. Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl -d 3) dilution in rats. J Appl Physiol. 2012;112: 1940-8.
6. Hoberman HD, Sims EAH, Peters JH. Creatine and creatinine metabolism in the normal male adult studied with the aid of isotopic nitrogen. J Biol Chem. 1948;172: 45-58.
7. Kreisberg RA, Bowdoin B, Meador C. Measurement of muscle mass in humans by isotopic dilution of creatine- 14 C. J Appl Physiol. 1970;28: 264-7.
8. Meador C, Kreisberg RA, Friday JP, Bowdoin B, Coan P, Armstrong J, et al. Muscle mass determination by isotopic dilution of creatine- 14 C. Metabolism. 1968;17: 1104-8.
9. Bloch K, Schoenheimer R, Rittenberg D. Rate of formation and disappearance of body creatine in normal animals. J Biol Chem. 1941;138: 155-66.
10. Borsook H, Dubnoff JW. The hydrolysis of phophocreatine and the origin of urinary creatinine. J Biol Chem. 1947;168: 493-510.
11. Fitch CD, Lucy DD, Bornhofen JH, Dalrymple GV. Creatine metabolism in skeletal muscle. II. Creatine kinetics in man. Neurology. 1968;18: 32-42.
12. Hoberman HD, Sims EAH, Engstrom WW. The effect of methyltestosterone on the rate of synthesis of creatine. J Biol Chem. 1948;173: 111-6.