The addicted brain

Frontiers in Psychiatry

Volumn 4, Issue JUN, 2013, Pages

  Diana, Marco ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; CANNABIS; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR; METHYLPHENIDATE; METIROSINE; MORPHINE; RACLOPRIDE;

ALCOHOLISM; BEHAVIOR DISORDER; BRAIN DISEASE; DISEASE CLASSIFICATION; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; DRUG DEPENDENCE; DRUG RECEPTOR BINDING; DSM-IV-TR; FUNDING; HUMAN; INTUITION; NERVE CELL PLASTICITY; NEUROBIOLOGY; NONHUMAN; NOTE; NUCLEUS ACCUMBENS; RECEPTOR DOWN REGULATION; SOCIAL ASPECT; WITHDRAWAL SYNDROME;

EID: 84884546387     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2013.00040     Document Type: Note

References (26)

1. Biggio, G., Cibin, M., Diana, M., Fadda, F., Ferrara, S. D., Gallimberti, L., et al. (1992). Suppression of voluntary alcohol intake in rats and alcoholics by gamma-hydroxybutyric acid: a non-GABAergic mechanism. Adv. Biochem. Psychopharmacol. 47, 281-288.
2. Boileau, I., Assaad, J. M., Pihl, R. O., Benkelfat, C., Leyton, M., Diksic, M., et al. (2003). Alcohol promotes dopamine release in the human nucleus accumbens. Synapse 15, 226-231. doi: 10.1002/syn.10226
3. Diana, M., Brodie, M., Muntoni, A., Puddu, M. C., Pillolla, G., Steffensen, S., et al. (2003). Enduring effects of chronic ethanol in the CNS: basis for alcoholism. Alcohol. Clin. Exp. Res. 27, 354-361. doi: 10.1097/01.ALC.0000057121.36127.19
4. Diana, M., Melis, M., Muntoni, A. L., and Gessa, G. L. (1998). Mesolimbic dopaminergic decline after cannabinoid withdrawal. Proc. Natl. Acad. Sci. U.S.A. 95, 10269-10273. doi: 10.1073/pnas.95.17.10269
5. Diana, M., Pistis, M., Carboni, S., Gessa, G. L., and Rossetti, Z. L. (1993). Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence. Proc. Natl. Acad. Sci. U.S.A. 90, 7966-7969. doi: 10.1073/pnas.90.17.7966
6. Diana, M., Pistis, M., Muntoni, A. L., and Gessa, G. L. (1995). Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. J. Pharmacol. Exp. Ther. 272, 781-785.
7. Gallimberti, L., Canton, G., Gentile, N., Ferri, M., Cibin, M., Ferrara, S. D., et al. (1989). Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome. Lancet 2, 787-789. doi: 10.1016/S0140-6736(89)90842-8
8. Koob, G. F., and Le Moal, M. (1997). Drug abuse: hedonic homeostatic dysregulation. Science 278, 52-58. doi:10.1126/science.278.5335.52
9. Koob, G. F., and Le Moal, M. (2008). Addiction and the brain antireward system. Annu. Rev. Psychol. 59, 29-53. doi: 10.1146/annurev.psych.59.103006.093548
10. Koob, G. F., and Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology 35, 217-238. doi: 10.1038/npp.2009.110
11. Levy, N. (2013). Addiction is not a brain disease (and it matters). Front. Psychiatry 4:24. doi: 10.3389/fpsyt.2013.00024
12. Martinez, D., Gil, R., Slifstein, M., Hwang, D. R., Huang, Y., Perez, A., et al. (2005). Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum. Biol. Psychiatry 58, 779-786. doi: 10.1016/j.biopsych.2005.04.044
13. Martinez, D., Greene, K., Broft, A., Kumar, D., Liu, F., Narendran, R., et al. (2009). Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. Am. J. Psychiatry 166, 1170-1177. doi: 10.1176/appi.ajp.2009.08121801
14. Martinez, D., Kim, J. H., Krystal, J., and Abi-Dargham, A. (2007). Imaging the neurochemistry of alcohol and substance abuse. Neuroimaging Clin. N. Am. 17, 539-555. doi: 10.1016/j.nic.2007.07.004
15. Melis, M., Spiga, S., and Diana, M. (2005). The dopamine hypothesis of drug addiction: hypodopaminergic state. Int. Rev. Neurobiol. 63, 101-154. doi: 10.1016/S0074-7742(05)63005-X
16. Robinson, T. E., and Kolb, B. (1997). Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J. Neurosci. 17, 8491-8497.
17. Robinson, T. E., and Kolb, B. (2004). Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 47(Suppl. 1), 33-46. doi:10.1016/j.neuropharm.2004.06.025
18. Spiga, S., Lintas, A., Migliore, M., and Diana, M. (2010). Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence. Addict. Biol. 15, 266-276. doi:10.1111/j.1369-1600.2010.00218.x
19. Spiga, S., Puddu, M. C., Foddai, M., and Diana, M. (2003). Morphine withdrawal-induced abnormalities in the VTA: confocal laser scanning microscopy. Eur. J. Neurosci. 17, 605-612. doi:10.1046/j.1460-9568.2003.02435.x
20. Spiga, S., Puddu, M. C., Pisano, M., and Diana, M. (2005). Morphine withdrawal-induced morphological changes in the nucleus accumbens. Eur. J. Neurosci. 22, 2332-2340. doi: 10.1111/j.1460-9568.2005.04416.x
21. Thanos, P. K., Taintor, N. B., Rivera, S. N., Umegaki, H., Ikari, H., Roth, G., et al. (2004). DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Alcohol. Clin. Exp. Res. 28, 720-728. doi:10.1097/01.ALC.0000125270.30501.08
22. Thanos, P. K., Volkow, N. D., Freimuth, P., Umegaki, H., Ikari, H., Roth, G., et al. (2001). Overexpression of dopamine D2 receptors reduces alcohol self administration. J. Neurochem. 78, 1094-1103. doi:10.1046/j.1471-4159.2001.00492.x
23. Urban, N. B., Kegeles, L. S., Slifstein, M., Xu, X., Martinez, D., Sakr, E., et al. (2010). Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [11C] raclopride. Biol. Psychiatry 68, 689-696. doi: 10.1016/j.biopsych.2010.06.005
24. Volkow, N. D., Wang, G. J., Begleiter, H., Porjesz, B., Fowler, J. S., Telang, F., et al. (2006). High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors. Arch. Gen. Psychiatry 63, 999-1008. doi: 10.1001/archpsyc.63.9.999
25. Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Hitzemann, R., Ding, Y. S., et al. (1996). Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin. Exp. Res. 20, 1594-1598. doi: 10.1111/j.1530-0277.1996.tb05936.x
26. Volkow, N. D., Wang, G. J., Telang, F., Fowler, J. S., Logan, J., Jayne, M., et al. (2007). Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. J. Neurosci. 27, 12700-12706. doi: 10.1523/JNEUROSCI.3371-07.2007