Long-term evaluation of 'BARC 68Ge/68Ga generator' based on the nanoceria-polyacrylonitrile composite sorbent

Cancer Biotherapy and Radiopharmaceuticals

Volumn 28, Issue 8, 2013, Pages 631-637

  Chakravarty, Rubel ^a   Chakraborty, Sudipta ^a   Ram, Ramu ^a   Dash, Ashutosh ^a   Pillai, M R A ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

68Ge 68Ga generator; DOTA RGD2; DOTA TATE; nanoceria polyacrylonitrile (CeO2 PAN) composite; radiopharmaceuticals

Indexed keywords

GALLIUM 68; GERMANIUM 68; NANOCERIA POLYACRYLONITRILE; POLYACRYLONITRILE; RADIOISOTOPE; SORBENT; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; CLINICAL PRACTICE; COMPLEX FORMATION; DECOMPOSITION; ELUTION; EVALUATION; PRIORITY JOURNAL; PURIFICATION; RADIOACTIVITY; RADIOCHEMISTRY; SYNTHESIS;

ACRYLIC RESINS; CERIUM; GALLIUM RADIOISOTOPES; ISOTOPE LABELING; RADIOPHARMACEUTICALS;

EID: 84884542660     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2012.1470     Document Type: Article

References (24)

1. Rösch F. 68Ge/68Ga generators: Past, present, and future. Recent Results Cancer Res 2013;194:3.
2. Roesch F, Riss PJ. The renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in 68Ga radiopharmaceutical. chemistry. Curr Top Med Chem 2010;10: 1633.
3. Asti M, Pietri GD, Fraternal.i A, Grassi E, Sghedoni R, Fioroni F. Val.idation of 68Ge/68Ga generator processing by chemical. purification for routine clinical. application of 68Ga-DOTATOC. Nucl Med Biol 2008;35:721.
4. de Blois E, Sze Chan H, Naidoo C, Prince D, Krenning EP, Breeman WA. Characteristics of SnO2-based 68Ge/68Ga generator and aspects of radiolabelling DOTA-peptides. Appl Radiat Isot 2011;69:308.
5. Zhernosekov KP, Filosofov DV, Baum RP, Aschoff P, Bihl H, Razbash AA. Processing of generator-produced 68Ga for medical. application. J Nucl Med 2007;48:1741.
6. Mueller D, Klette I, Baum RP, Gottschal.dt M, Schultz MK, Breeman WAP. Simplified NaCl based 68Ga concentration and labeling procedure for rapid synthesis of 68Ga radiopharmaceutical.s in high radiochemical. purity. Bioconjug Chem 2012;23:1712.
7. Loktionova NS, Belozub AN, Filosofov DV, Zhernosekov KP, Wagner T, Turler A, Rosch F. Improved column-based radiochemical. processing of the generator produced 68Ga. Appl Radiat Isot 2011;69:942.
8. Rösch F. Post-processing via cation exchange cartridges: Versatile options. Recent Results Cancer Res 2013;194:33.
9. Mueller D, Klette I, Baum RP. Purification and labeling strategies for 68Ga from 68Ge/68Ga generator eluate. Recent Results Cancer Res 2013;194:77.
10. Chakravarty R, Shukla R, Ram R, Venkatesh M, Dash A, Tyagi AK. Nano-ceria-PAN composite based advanced sorbent material.: A major step forward in the field of clinical. grade 68Ge/68Ga generator. ACS Appl Mater Interfaces 2010; 2:2069.
11. Chakravarty R, Chakraborty S, Dash A, Pillai MRA. Detailed eval.uation on the effect of metal. ion impurities on complexation of generator eluted 68Ga with different bifunctional. chelators. Nucl Med Biol 2013;40:197.
12. Chakraborty S, Chakravarty R, Dash A, Pillai MRA. The practical.ity of nanoceria-PAN-based 68Ge/68Ga generator toward preparation of 68Ga-labeled cyclic RGD dimer as a potential. PET radiotracer for tumor imaging. Cancer Biother Radiopharm 2013;28:77.
13. Lin M, Ranganathan D, Mori T, Hagooly A, Rossin R, Welch MJ, Lapi SE. Long-term eval.uation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis. Appl Radiat Isot 2012;70:2539.
14. Vega I, Morris W, D'Accorso N. PAN chemical. modification: Synthesis and characterization of terpolymers with 1,2,4-oxadiazolic pendant groups. React Funct Polym 2006;66: 1609.
15. Hartmann H, Zöphel K, Freudenberg R, Oehme L, Andreeff M, Wunderlich G, Eisenhofer G, Kotzerke J. Radiation exposure of patients during 68Ga-DOTATOC PET/CT examinations. Nuklearmedizin 2009;48:201.
16. Ezziddin S, Lohmar J, Yong-Hing CJ, Sabet A, Ahmadzadehfar H, Kukuk G, Biersack HJ, Guhlke S, Reichmann K. Does the pretherapeutic tumor SUV in 68Ga DOTATOC PET predict the absorbed dose of 177Lu octreotate? Clin Nucl Med 2012;37:e141.
17. Razbash AA Sevastianov YG Krasnov NN Leonov AI Pavlekhin VE.,Germanium-68 row of products,Proceedings of the Fifth International
18. Bologna, Ital.y, (Medimond) 2005,147-151.
19. IGG100 68Ge/68Ga Generator Product Information by Eckert & Ziegler AG, Berlin, Germany. Available at: www.radiustech .it/public/files/1d000044.pdf (accessed on December 1, 2012).
20. Aardaneh K, van der Wal.t TN. Ga2O for target, solvent extraction for radiochemical. separation and SnO2 for the preparation of a 68Ge/68Ga generator. J Radioanal. Nucl Chem 2006;268:25.
21. Rosenfeld G. Studies of the metabolism of germanium. Arch Biochem Biophys 1954;48:84.
22. Bai XM, Voter AF, Hoagland RG, Nastasi M, Uberuaga BP. Efficient anneal.ing of radiation damage near grain boundaries via interstitial. emission. Science 2010; 327:1631.
23. Sebesta F. Composite sorbents of inorganic ion-exchangers and polyacrylonitrile binding matrix I. Methods of modification of properties of inorganic ion-exchangers for application in column packed beds. J Radioanal. Nucl Chem 1997;220:77.
24. Sebesta F, John J, Motl A, Stamberg K. Eval.uation of polyacrylonitrile (PAN) as a binding polymer for absorbers used to treat liquid radioactive wastes. SNL Report-SAND95-2729; Sandia National. Laboratories: Al.buquerque, NM, 1995.