Complex Fitness Diagrams: Downstream Processing of Biologicals

Separation Science and Technology (Philadelphia)

Volumn 48, Issue 12, 2013, Pages 1753-1757

  Lightfoot, E N ^a   Cockrem, M C M ^b  

^a University of Wisconsin Madison   (United States)

^b KiwiChem International   (United States)

Author keywords

chromatography; counterflow; downstream processing; fitness diagrams; heuristics; orders of magnitude; scale up

Indexed keywords

COUNTERFLOW; DOWNSTREAM-PROCESSING; FITNESS DIAGRAMS; HEURISTICS; ORDERS OF MAGNITUDE; SCALE-UP;

CHROMATOGRAPHY; PROTEINS;

PURIFICATION;

EID: 84884542624     PISSN: 01496395     EISSN: 15205754     Source Type: Journal    
DOI: 10.1080/01496395.2013.779281     Document Type: Article

References (15)

1. Johnson, N. (2008) Sewell Wright and the development of shifting balance theory. Nature Education, 1: 1.
2. Horvath, C. (1983) High Performance Liquid Chromatography; Academic Press: NY.
3. Lightfoot, E.N. (2004) Emergence (unpredictability) and the evolution of novel designs. Chem. Eng., Japan, 37 (2): 125-136.
4. Sole', R.; Goodwin, B. (2000) Signs of Life; Basic Books, scattered throughout.
5. Sherwood, T.K.; Pigford, R.L.; Wilke, C.R. (1975) Mass Transfer, 1975, Fig. 1.2, p. 3.
6. Dwyer, J.L. (1984) Product purification and downstream processing. Biotech, 1: 957.
7. Lightfoot, E.N.; Cockrem, M.C. M. (1987) What are dilute solutions? Sep. Sci. Tech., 25: 165-189.
8. Busche, R.M. (1985) The business of biomass. Biotech. Prog., 1 (9): 165.
9. Lightfoot, E.N. (2005) Can membrane cascades replace chromatography? Sep. Sci. Tech., 40: 739-756.
10. Gunderson, S.S.; Brower, W.S.; Lightfoot, E.N. (2007) Design of membrane cascades. Sep. Sci. Tech., 42: 2121-2142.
11. Lightfoot, E.N.; Root, T.W.; O'Del, J.L. (2008) Emergence of membrane cascades for downstream processing. Biotech. Prog., 24: 599-605.
12. Lightfoot, E.N. (2006) Membrane cascade based separation. US Patent 7, 141, 171, Nov. 28.
13. Lightfoot, E.N.; Cockrem, M.C. M. (2012) Membrane based separations. US Patent 8,152, 999, April 10.
14. Shinkazh, O.; Zydney, A. (2012) Countercurrent Tangential Chromatography for Purification of Monoclonal Antibodies. L204 In Prep 2012, Boston, MA. wwwprepsymposiumorg, July 15-18.
15. Ocean Optics, Inc.