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Volumn 26, Issue 10, 2013, Pages 1107-1117

Novel pathogenetic mechanisms and structural adaptations in ischemic mitral regurgitation

Author keywords

Atriogenic leaflet tethering; Echocardiography; Epithelial mesenchymal transition; Ischemic mitral regurgitation; Left ventricular false tendons; Mitral annulus; Papillary muscles; Ventricular valvular continuity

Indexed keywords

ANNULOPLASTY; DISEASE SEVERITY; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; HEART ATRIUM CONTRACTION; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART PAPILLARY MUSCLE; HUMAN; MITRAL VALVE REGURGITATION; MOLECULAR MECHANICS; MYOFIBROBLAST; REVIEW; SINUS RHYTHM;

EID: 84884534542     PISSN: 08947317     EISSN: 10976795     Source Type: Journal    
DOI: 10.1016/j.echo.2013.07.003     Document Type: Review
Times cited : (39)

References (53)
  • 1
    • 0035799329 scopus 로고    scopus 로고
    • Ischemic mitral regurgitation: Long-term outcome and prognostic implications with quantitative Doppler assessment
    • F. Grigioni, M. Enriquez-Sarano, K.J. Zehr, K.R. Bailey, and A.J. Tajik Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment Circulation 103 2001 1759 1764
    • (2001) Circulation , vol.103 , pp. 1759-1764
    • Grigioni, F.1    Enriquez-Sarano, M.2    Zehr, K.J.3    Bailey, K.R.4    Tajik, A.J.5
  • 2
    • 79959565018 scopus 로고    scopus 로고
    • Mechanistic insights into ischemic mitral regurgitation: Echocardiographic and surgical implications
    • J.J. Silbiger Mechanistic insights into ischemic mitral regurgitation: echocardiographic and surgical implications J Am Soc Echocardiogr 24 2011 70& 719
    • (2011) J Am Soc Echocardiogr , vol.24 , pp. 707-719
    • Silbiger, J.J.1
  • 3
    • 84864653816 scopus 로고    scopus 로고
    • Anatomy, mechanics and pathophysiology of the mitral annulus
    • J.J. Silbiger Anatomy, mechanics and pathophysiology of the mitral annulus Am Heart J 164 2012 163 176
    • (2012) Am Heart J , vol.164 , pp. 163-176
    • Silbiger, J.J.1
  • 5
    • 57749187827 scopus 로고    scopus 로고
    • Left ventricular response to mitral regurgitation: Implications for management
    • W.H. Gaasch, and T.E. Meyer Left ventricular response to mitral regurgitation: implications for management Circulation 118 2008 2298 2303
    • (2008) Circulation , vol.118 , pp. 2298-2303
    • Gaasch, W.H.1    Meyer, T.E.2
  • 6
    • 0344185344 scopus 로고    scopus 로고
    • Determinants of exercise-induced changes in mitral regurgitation in patients with coronary artery disease and left ventricular dysfunction
    • P. Lancellotti, F. Lebrun, and L.A. Pierard Determinants of exercise-induced changes in mitral regurgitation in patients with coronary artery disease and left ventricular dysfunction J Am Coll Cardiol 42 2004 1921 1928
    • (2004) J Am Coll Cardiol , vol.42 , pp. 1921-1928
    • Lancellotti, P.1    Lebrun, F.2    Pierard, L.A.3
  • 7
    • 53749101711 scopus 로고    scopus 로고
    • Mitral leaflet adaptation to ventricular remodeling: Occurrence and adequacy in patients with functional mitral regurgitation
    • M. Chaput, M.D. Handschumacher, F. Tournoux, L. Hua, J.L. Guererro, and G.J. Vlahakes Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation Circulation 118 2008 845 852
    • (2008) Circulation , vol.118 , pp. 845-852
    • Chaput, M.1    Handschumacher, M.D.2    Tournoux, F.3    Hua, L.4    Guererro, J.L.5    Vlahakes, G.J.6
  • 8
    • 68249138605 scopus 로고    scopus 로고
    • Active adaptation of the tethered mitral valve: Insights into a compensatory mechanism for functional mitral regurgitation
    • J.P. Dal-Bianco, E. Aikawa, J. Bischoff, L. Guerrero, and M.D. Handschumacher Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation Circulation 120 2009 3334 3342
    • (2009) Circulation , vol.120 , pp. 3334-3342
    • Dal-Bianco, J.P.1    Aikawa, E.2    Bischoff, J.3    Guerrero, L.4    Handschumacher, M.D.5
  • 10
    • 0035899907 scopus 로고    scopus 로고
    • Paradoxic decrease in ischemic mitral regurgitation with papillary muscle dysfunction: Insights from three-dimensional and contrast echocardiography with strain rate measurement
    • E. Messas, L. Guerrero, M.D. Handschumacher, C.M. Chow, S. Sullivan, and E. Schwammenthal Paradoxic decrease in ischemic mitral regurgitation with papillary muscle dysfunction: insights from three-dimensional and contrast echocardiography with strain rate measurement Circulation 104 2001 1952 1957
    • (2001) Circulation , vol.104 , pp. 1952-1957
    • Messas, E.1    Guerrero, L.2    Handschumacher, M.D.3    Chow, C.M.4    Sullivan, S.5    Schwammenthal, E.6
  • 11
    • 0027534706 scopus 로고
    • Two-dimensional echocardiographic assessment of papillary muscle contractility in patients with prior myocardial infarction
    • A. Kisanuki, Y. Otsuji, R. Kuroiwa, T. Murayema, R. Matsushita, and K. Shihata Two-dimensional echocardiographic assessment of papillary muscle contractility in patients with prior myocardial infarction J Am Coll Cardiol 21 1993 932 938
    • (1993) J Am Coll Cardiol , vol.21 , pp. 932-938
    • Kisanuki, A.1    Otsuji, Y.2    Kuroiwa, R.3    Murayema, T.4    Matsushita, R.5    Shihata, K.6
  • 12
    • 3042568930 scopus 로고    scopus 로고
    • Assessment of papillary muscle function using myocardial velocity gradient derived from tissue Doppler echocardiography
    • B. Khankirawatana, S. Khankirawatana, H. Mahrous, and T.R. Porter Assessment of papillary muscle function using myocardial velocity gradient derived from tissue Doppler echocardiography Am J Cardiol 94 2009 45 49
    • (2009) Am J Cardiol , vol.94 , pp. 45-49
    • Khankirawatana, B.1    Khankirawatana, S.2    Mahrous, H.3    Porter, T.R.4
  • 13
    • 21344446567 scopus 로고    scopus 로고
    • Papillary muscle dysfunction attenuates ischemic mitral regurgitation in patients with localized basal inferior left ventricular remodeling: Insights from tissue Doppler strain imaging
    • T. Uemura, Y. Otsuji, K. Nakashiki, S. Yoshifuku, Y. Maki, and B. Yu Papillary muscle dysfunction attenuates ischemic mitral regurgitation in patients with localized basal inferior left ventricular remodeling: insights from tissue Doppler strain imaging J Am Coll Cardiol 46 2005 133 139
    • (2005) J Am Coll Cardiol , vol.46 , pp. 133-139
    • Uemura, T.1    Otsuji, Y.2    Nakashiki, K.3    Yoshifuku, S.4    Maki, Y.5    Yu, B.6
  • 14
    • 72049104216 scopus 로고    scopus 로고
    • Effects and mechanisms of left ventricular false tendons on functional mitral regurgitation in patients with severe cardiomyopathy
    • M.R. Bhatt, C.E. Alfonso, A.M. Bhatt, S. Lee, A.C. Ferriera, and T.A. Salemo Effects and mechanisms of left ventricular false tendons on functional mitral regurgitation in patients with severe cardiomyopathy J Thorac Cardiothorac Surg 138 2009 1123 1128
    • (2009) J Thorac Cardiothorac Surg , vol.138 , pp. 1123-1128
    • Bhatt, M.R.1    Alfonso, C.E.2    Bhatt, A.M.3    Lee, S.4    Ferriera, A.C.5    Salemo, T.A.6
  • 15
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • J.P. Thiery, H. Acloque, R.Y.J. Huang, and M.A. Nieto Epithelial-mesenchymal transitions in development and disease Cell 139 2009 871 890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.J.3    Nieto, M.A.4
  • 16
    • 84862284813 scopus 로고    scopus 로고
    • Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease
    • A. von Gise, and W. Pu Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease Circ Res 110 2012 2628 2645
    • (2012) Circ Res , vol.110 , pp. 2628-2645
    • Von Gise, A.1    Pu, W.2
  • 18
    • 81855170051 scopus 로고    scopus 로고
    • Progenitor cells confer plasticity to cardiac valve endothelium
    • J. Bischoff, and E. Aikawa Progenitor cells confer plasticity to cardiac valve endothelium J Cardiovasc Trans Res 4 2011 710 719
    • (2011) J Cardiovasc Trans Res , vol.4 , pp. 710-719
    • Bischoff, J.1    Aikawa, E.2
  • 21
    • 70549113207 scopus 로고    scopus 로고
    • Contemporary insights into the functional anatomy of the mitral valve
    • J.J. Silbiger, and R. Bazaz Contemporary insights into the functional anatomy of the mitral valve Am Heart J 158 2009 88& 895
    • (2009) Am Heart J , vol.158 , pp. 887-895
    • Silbiger, J.J.1    Bazaz, R.2
  • 23
    • 8444228521 scopus 로고    scopus 로고
    • Ischemic mitral valve prolapse: Mechanisms and implications for valve repair
    • J. Jouan, M. Tapia, R.C. Cook, R.C. Lansac, and C. Acar Ischemic mitral valve prolapse: mechanisms and implications for valve repair Eur J Cardiothorac Surg 26 2004 1112 1117
    • (2004) Eur J Cardiothorac Surg , vol.26 , pp. 1112-1117
    • Jouan, J.1    Tapia, M.2    Cook, R.C.3    Lansac, R.C.4    Acar, C.5
  • 24
    • 77950224228 scopus 로고    scopus 로고
    • Mitral annular dynamics in myxomatous disease: New insights with real-time 3-dimensional echocardiography
    • J. Grewal, R. Suri, S. Mankad, A. Tanaka, D.W. Mahohey, and H.V. Schaff Mitral annular dynamics in myxomatous disease: new insights with real-time 3-dimensional echocardiography Circulation 121 2010 1423 1431
    • (2010) Circulation , vol.121 , pp. 1423-1431
    • Grewal, J.1    Suri, R.2    Mankad, S.3    Tanaka, A.4    Mahohey, D.W.5    Schaff, H.V.6
  • 26
    • 0032990789 scopus 로고    scopus 로고
    • Mitral valve compensation for annular dilatation: In vitro study into the mechanisms of functional mitral regurgitation with an adjustable annulus model
    • S. He, J.D. Lemmon, M.W. Weston, M.O. Jensen, R.A. Levine, and A.P. Yoganathan Mitral valve compensation for annular dilatation: in vitro study into the mechanisms of functional mitral regurgitation with an adjustable annulus model J Heart Valve Dis 8 1999 294 302
    • (1999) J Heart Valve Dis , vol.8 , pp. 294-302
    • He, S.1    Lemmon, J.D.2    Weston, M.W.3    Jensen, M.O.4    Levine, R.A.5    Yoganathan, A.P.6
  • 27
    • 77649220359 scopus 로고    scopus 로고
    • Mitral regurgitation in lone atrial fibrillation: More than a matter of annular size
    • J.J. Silbiger Mitral regurgitation in lone atrial fibrillation: more than a matter of annular size Echocardiography 2& 2010 218
    • (2010) Echocardiography , vol.27 , pp. 218
    • Silbiger, J.J.1
  • 28
    • 77956048934 scopus 로고    scopus 로고
    • Does isolated annular dilatation cause hemodynamically significant mitral regurgitation?
    • J.J. Silbiger Does isolated annular dilatation cause hemodynamically significant mitral regurgitation? J Heart Valve Dis 19 2010 541 542
    • (2010) J Heart Valve Dis , vol.19 , pp. 541-542
    • Silbiger, J.J.1
  • 29
    • 0025266820 scopus 로고
    • Ventricular remodeling after myocardial infarction: Experimental observations and clinical applications
    • M.A. Pfeffer, and E. Braunwald Ventricular remodeling after myocardial infarction: experimental observations and clinical applications Circulation 81 1990 1161 1172
    • (1990) Circulation , vol.81 , pp. 1161-1172
    • Pfeffer, M.A.1    Braunwald, E.2
  • 30
    • 0022650005 scopus 로고
    • Incidence and distribution of left ventricular false tendons: An autopsy study of 483 normal human hearts
    • P.H. Luetmer, W.D. Edwards, J.B. Seward, and A.J. Tajik Incidence and distribution of left ventricular false tendons: an autopsy study of 483 normal human hearts J Am Coll Cardiol 8 1986 179 183
    • (1986) J Am Coll Cardiol , vol.8 , pp. 179-183
    • Luetmer, P.H.1    Edwards, W.D.2    Seward, J.B.3    Tajik, A.J.4
  • 31
    • 80055080505 scopus 로고    scopus 로고
    • Left ventricular false tendons: Echocardiographic, morphologic, and histopathologic studies and review of the literature
    • S. Philip, K.M. Cherian, M. Wu, and H. Lue Left ventricular false tendons: echocardiographic, morphologic, and histopathologic studies and review of the literature Pediatr Neonatol 52 2001 279 286
    • (2001) Pediatr Neonatol , vol.52 , pp. 279-286
    • Philip, S.1    Cherian, K.M.2    Wu, M.3    Lue, H.4
  • 32
    • 84878335346 scopus 로고    scopus 로고
    • Left ventricular false tendons: Anatomic, echocardiographic and pathophysiologic insights
    • J.J. Silbiger Left ventricular false tendons: anatomic, echocardiographic and pathophysiologic insights J Am Soc Echocardiogr 26 2013 582 588
    • (2013) J Am Soc Echocardiogr , vol.26 , pp. 582-588
    • Silbiger, J.J.1
  • 34
    • 0014805702 scopus 로고
    • Structural basis for cardiac function
    • J.A. Armour, and W.C. Randall Structural basis for cardiac function Am J Physiol 218 1970 151& 1523
    • (1970) Am J Physiol , vol.218 , pp. 1517-1523
    • Armour, J.A.1    Randall, W.C.2
  • 35
    • 84872903538 scopus 로고    scopus 로고
    • A novel mechanism by which MitraClip implantation may favorably alter the natural history of left ventricular remodeling in patients with mitral regurgitation: Proposed role of the ventricular-valvular loop
    • J.J. Silbiger A novel mechanism by which MitraClip implantation may favorably alter the natural history of left ventricular remodeling in patients with mitral regurgitation: proposed role of the ventricular-valvular loop J Am Soc Echocardiogr 26 2013 21& 219
    • (2013) J Am Soc Echocardiogr , vol.26 , pp. 217-219
    • Silbiger, J.J.1
  • 37
    • 34748834130 scopus 로고    scopus 로고
    • Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: A functional and molecular study
    • R. Beeri, C. Yosefy, L. Guerrero, S. Adebat, M.D. Handschumacher, and R.E. Strou Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study Circulation 116 suppl 200& I-288-93
    • (2007) Circulation , vol.116 , Issue.SUPPL. , pp. 288-293
    • Beeri, R.1    Yosefy, C.2    Guerrero, L.3    Adebat, S.4    Handschumacher, M.D.5    Strou, R.E.6
  • 38
    • 78649693692 scopus 로고    scopus 로고
    • Outcomes of the RESTOR-MV trial (Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve)
    • E.A. Grossi, N. Patel, J. Woo, J.D. Goldberg, C.F. Schwartz, and V. Subramanian Outcomes of the RESTOR-MV trial (Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve) J Am Coll Cardiol 56 2010 1984 1993
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1984-1993
    • Grossi, E.A.1    Patel, N.2    Woo, J.3    Goldberg, J.D.4    Schwartz, C.F.5    Subramanian, V.6
  • 39
    • 29144494144 scopus 로고    scopus 로고
    • Coapsys mitral annuloplasty for chronic functional ischemic mitral regurgitation: 1-year results
    • Y.K. Mishra, S. Mittal, P. Jaguri, and N. Trehan Coapsys mitral annuloplasty for chronic functional ischemic mitral regurgitation: 1-year results Ann Thorac Surg 81 2006 42 46
    • (2006) Ann Thorac Surg , vol.81 , pp. 42-46
    • Mishra, Y.K.1    Mittal, S.2    Jaguri, P.3    Trehan, N.4
  • 40
    • 84861619044 scopus 로고    scopus 로고
    • Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: Importance of residual stress
    • R. Carrick, L. Ge, L.C. Lee, Z. Zhang, R. Mishra, and L. Axel Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress Ann Thorac Surg 93 2012 1964 1971
    • (2012) Ann Thorac Surg , vol.93 , pp. 1964-1971
    • Carrick, R.1    Ge, L.2    Lee, L.C.3    Zhang, Z.4    Mishra, R.5    Axel, L.6
  • 41
    • 78649699486 scopus 로고    scopus 로고
    • Coapsys leads to global reversal of left ventricular remodeling: Expanded TRACE study analysis
    • S. Mittal, Y. Mishra, and N. Trehan Coapsys leads to global reversal of left ventricular remodeling: expanded TRACE study analysis Circulation 116 suppl 200& II-373
    • (2007) Circulation , vol.116 , Issue.SUPPL. , pp. 373
    • Mittal, S.1    Mishra, Y.2    Trehan, N.3
  • 42
    • 0037420116 scopus 로고    scopus 로고
    • Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure
    • A. Breithardt, A.M. Sinha, E. Schwammenthal, N. Bidaoui, K.U. Markus, and A. Franke Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure J Am Coll Cardiol 41 2003 765 770
    • (2003) J Am Coll Cardiol , vol.41 , pp. 765-770
    • Breithardt, A.1    Sinha, A.M.2    Schwammenthal, E.3    Bidaoui, N.4    Markus, K.U.5    Franke, A.6
  • 43
    • 5644236575 scopus 로고    scopus 로고
    • A mechanism for immediate reduction in mitral regurgitation after cardiac resynchronization
    • H. Kanzaki, R. Bazaz, D. Schwartzman, K. Dohi, and L.E. Sade A mechanism for immediate reduction in mitral regurgitation after cardiac resynchronization J Am Coll Cardiol 44 2004 1619 1625
    • (2004) J Am Coll Cardiol , vol.44 , pp. 1619-1625
    • Kanzaki, H.1    Bazaz, R.2    Schwartzman, D.3    Dohi, K.4    Sade, L.E.5
  • 44
    • 79957883109 scopus 로고    scopus 로고
    • Impact of cardiac resynchronization therapy on the severity of mitral regurgitation
    • L. Di Biase, A. Auricchio, P. Mohanty, R. Bai, J. Kautzner, and P. Pierangoli Impact of cardiac resynchronization therapy on the severity of mitral regurgitation Europace 13 2011 829 838
    • (2011) Europace , vol.13 , pp. 829-838
    • Di Biase, L.1    Auricchio, A.2    Mohanty, P.3    Bai, R.4    Kautzner, J.5    Pierangoli, P.6
  • 45
    • 84856703647 scopus 로고    scopus 로고
    • Impact of mitral regurgitation on the outcome of patients treated with CRT-DL data from the in Sync ICD Registry
    • G. Boriani, M. Gasparini, M. Landolina, M. Lunati, M. Biffi, and M. Sntini Impact of mitral regurgitation on the outcome of patients treated with CRT-DL data from the In Sync ICD Registry Pacing Clin Electrophysiol 25 2012 146 154
    • (2012) Pacing Clin Electrophysiol , vol.25 , pp. 146-154
    • Boriani, G.1    Gasparini, M.2    Landolina, M.3    Lunati, M.4    Biffi, M.5    Sntini, M.6
  • 49
    • 0032451035 scopus 로고    scopus 로고
    • Altered collagen concentrations in mitral valve leaflets: Biochemical and finite element analysis
    • K.S. Kunzelman, D.W. Quick, and R.P. Cochran Altered collagen concentrations in mitral valve leaflets: biochemical and finite element analysis Ann Thorac Surg 66S 1998 198 205
    • (1998) Ann Thorac Surg , vol.66 S , pp. 198-205
    • Kunzelman, K.S.1    Quick, D.W.2    Cochran, R.P.3
  • 50
    • 80052979521 scopus 로고    scopus 로고
    • Evidence of atrial functional mitral regurgitation due to atrial fibrillation: Reversal with arrhythmia control
    • Z.M. Gertz, A. Raina, L. Saghy, E.S. Zado, D.J. Callans, and F.E. Marchlinski Evidence of atrial functional mitral regurgitation due to atrial fibrillation: reversal with arrhythmia control J Am Coll Cardiol 58 2011 1474 1481
    • (2011) J Am Coll Cardiol , vol.58 , pp. 1474-1481
    • Gertz, Z.M.1    Raina, A.2    Saghy, L.3    Zado, E.S.4    Callans, D.J.5    Marchlinski, F.E.6
  • 51
    • 0019490187 scopus 로고
    • Size and motion of the mitral valve annulus in man. I. A two-dimensional echocardiographic method and findings in normal subjects
    • J.A. Ormiston, P.M. Shah, C. Tei, and M. Wong Size and motion of the mitral valve annulus in man. I. A two-dimensional echocardiographic method and findings in normal subjects Circulation 64 1981 1113 1120
    • (1981) Circulation , vol.64 , pp. 1113-1120
    • Ormiston, J.A.1    Shah, P.M.2    Tei, C.3    Wong, M.4
  • 52
    • 0037266920 scopus 로고    scopus 로고
    • Effect of atrial fibrillation on the dynamics of mitral annular area
    • R. Pai, P. Varadarajan, and M. Tanimoto Effect of atrial fibrillation on the dynamics of mitral annular area J Heart Valve Dis 12 2003 31 37
    • (2003) J Heart Valve Dis , vol.12 , pp. 31-37
    • Pai, R.1    Varadarajan, P.2    Tanimoto, M.3
  • 53
    • 0343487860 scopus 로고    scopus 로고
    • Most ovine mitral annular three-dimensional size reduction occurs before ventricular systole and is abolished with ventricular pacing
    • J.G. Glasson, M. Komeda, G.T. Daughters, L.E. Foppiano, A.F. Bolger, and T.L. Tye Most ovine mitral annular three-dimensional size reduction occurs before ventricular systole and is abolished with ventricular pacing Circulation 96 suppl 199& 115 123
    • (1997) Circulation , vol.96 , Issue.SUPPL. , pp. 115-123
    • Glasson, J.G.1    Komeda, M.2    Daughters, G.T.3    Foppiano, L.E.4    Bolger, A.F.5    Tye, T.L.6


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