Myocardial protection by volatile anesthetics in patients undergoing cardiac surgery: A critical review of the laboratory and clinical evidence

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 27, Issue 5, 2013, Pages 972-982

  Pagel, Paul S ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

coronary artery disease; Myocardial ischemia; postconditioning; preconditioning; volatile anesthetics

Indexed keywords

INHALATION ANESTHETIC AGENT; ISOFLURANE; MIDAZOLAM; PLACEBO; PROPOFOL; SEVOFLURANE;

AORTA CLAMPING; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS GRAFT; HEART ATRIUM FIBRILLATION; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART SURGERY; HUMAN; ISCHEMIC PRECONDITIONING; META ANALYSIS; PRIORITY JOURNAL; REVIEW;

CORONARY ARTERY DISEASE; MYOCARDIAL ISCHEMIA; POSTCONDITIONING; PRECONDITIONING; VOLATILE ANESTHETICS;

ANESTHETICS, INHALATION; ANIMALS; CARDIAC SURGICAL PROCEDURES; CLINICAL TRIALS AS TOPIC; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL ISCHEMIA; POSTOPERATIVE COMPLICATIONS;

EID: 84884532513     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2012.10.011     Document Type: Review

References (99)

1. J.H.L. Bland, and E. Lowenstein Halothane-induced decrease in experimental myocardial ischemia in the non-failing canine heart Anesthesiology 45 1976 287 293
2. D.C. Warltier, M.H. Al-Wathiqui, and J.P. Kampine Recovery of contractile function of stunned myocardium in chronically instrumented dogs is enhanced by halothane or isoflurane Anesthesiology 69 1988 552 565
3. N. Kanaya, and S. Fujita The effects of isoflurane on regional myocardial contractility and metabolism in "stunned" myocardium in acutely instrumented dogs Anesth Analg 79 1994 447 454
4. J. Marijic, D.F. Stowe, and L.A. Turner Differential protective effects of halothane and isoflurane against hypoxic and reoxygenation injury in the isolated guinea pig heart Anesthesiology 73 1990 976 983
5. A. Lochner, I.S. Harper, and R. Salie Halothane protects the isolated rat myocardium against excessive total intracellular calcium and structural damage during ischemia and reperfusion Anesth Analg 79 1994 226 233
6. B.A. Cason, A.K. Gamperl, and R.E. Slocum Anesthetic-induced preconditioning. Previous administration of isoflurane decreases myocardial infarct size in rabbits Anesthesiology 87 1997 1182 1190
7. D.K. Cope, W.K. Impastato, and M.V. Cohen Volatile anesthetics protect the ischemic rabbit myocardium from infarction Anesthesiology 86 1997 699 709
8. ATP channels. Reduction of myocardial infarct size with an acute memory phase Anesthesiology 87 1997 361 370
9. P.S. Pagel Postconditioning by volatile anesthetics: Salvaging ischemic myocardium at reperfusion by activation of prosurvival signaling J Cardiothorac Vasc Anesth 22 2008 753 765
10. P.S. Pagel, and J.A. Hudetz Delayed cardioprotection by inhaled anesthetics J Cardiothoracic Vasc Anesth 25 2011 1125 1140
11. M. Zaugg, E. Lucchinetti, and M. Uecker Anaesthetics and cardiac preconditioning. Part I. Signaling and cytoprotective mechanisms Br J Anaesth 91 2003 551 565
12. M. Zaugg, E. Lucchinetti, and C. Garcia Anaesthetics and cardiac preconditioning. Part II. Clinical implications Br J Anaesth 91 2003 566 576
13. K. Tanaka, L.M. Ludwig, and J.R. Kersten Mechanisms of cardioprotection by volatile anesthetics Anesthesiology 100 2004 707 721
14. S.G. De Hert, F. Turani, and S. Mathur Cardioprotection with volatile anesthetics: Mechanisms and clinical implications Anesth Analg 100 2005 1584 1593
15. J. Frassdorf, S. De Hert, and W. Schlack Anaesthesia and myocardial ischaemia/reperfusion injury Br J Anaesth 103 2009 89 98
16. A.K. Roscoe, J.D. Christensen, and C. Lynch 3rd Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels Anesthesiology 92 2000 1692 1701
17. J.L. Hanouz, A. Yvon, and M. Massetti Mechanisms of desflurane-induced preconditioning in isolated human right atria in vitro Anesthesiology 97 2002 33 41
18. A. Yvon, J.L. Hanouz, and B. Haelewyn Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro Anesthesiology 99 2003 27 33
19. M.T. Jiang, Y. Nakae, and M. Ljubkovic Isoflurane activates human cardiac mitochondrial adenosine triphosphate-sensitive K+ channels reconstituted in lipid bilayers Anesth Analg 105 2007 926 932
20. J. Mullenheim, D. Ebel, and J. Frassdorf Isoflurane preconditions myocardium against infarction via release of free radicals Anesthesiology 96 2002 934 940
21. K. Tanaka, D. Weihrauch, and F. Kehl Mechanism of preconditioning by isoflurane in rabbits: A direct role for reactive oxygen species Anesthesiology 97 2002 1485 1490
22. J.L. Hanouz, L. Zhu, and S. Lemoine Reactive oxygen species mediate sevoflurane- and desflurane-induced preconditioning in isolated human right atria in vitro Anesth Analg 105 2007 1534 1539
23. D.J. Hausenloy, and D.M. Yellon New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway Cardiovasc Res 61 2004 448 460
24. L. Zhu, S. Lemoine, and G. Babatasi Sevoflurane- and desflurane-induced human myocardial post-conditioning through phosphatidylinositol-3-kinase/Akt signaling Acta Anaesthesiol Scand 53 2009 949 956
25. N.C. Weber, J. Kandler, and W. Schlack Intermitted pharmacological pretreatment by xenon, isoflurane, nitrous oxide, and the opioid morphine prevents tumor necrosis factor a-induced adhesion molecule expression in human umbilical vein endothelial cells Anesthesiology 108 2008 199 207
26. E. Lucchinetti, S. Ambrosio, and J. Aguirre Sevoflurane inhalation at sedative concentrations provides endothelial protection against ischemia-reperfusion injury in humans Anesthesiology 106 2007 262 268
27. A. Sepac, F. Sedlic, and K. Si-Tayeb Isoflurane preconditioning elicits competent endogenous mechanisms of protection from oxidative stress in cardiomyocytes derived from human embryonic stem cells Anesthesiology 113 2010 906 916
28. J.H. Kim, A.Y. Oh, and Y.M. Choi Isoflurane decreases death of human embryonic stem cell-derived, transcriptional marker Nkx2.5+ cardiac progenitor cells Acta Anaesthesiol Scand 55 2011 1124 1131
29. A. Penta de Peppo, P. Polisca, and F. Tomai Recovery of LV contractility in man is enhanced by preischemic administration of enflurane Ann Thorac Surg 68 1999 112 118
30. F. Tomai, R. De Paulis, and A. Penta de Peppo Beneficial impact of isoflurane during coronary bypass surgery on troponin I release G Ital Cardiol 29 1999 1007 1014
31. D. Belhomme, J. Peynet, and M. Louzy Evidence for preconditioning by isoflurane in coronary artery bypass graft surgery Circulation 100 1999 II340 II344
32. S.G. De Hert, S. Cromheecke, and P.W. ten Broecke Effects of propofol, desflurane, and sevoflurane on recovery of myocardial function after coronary artery surgery in elderly high-risk patients Anesthesiology 99 2003 314 323
33. S.G. De Hert, P.W. ten Broecke, and E. Mertens Sevoflurane but not propofol preserves myocardial function in coronary surgery patients Anesthesiology 97 2002 42 49
34. S. Cromheecke, V. Pepermans, and E. Hendrickx Cardioprotective properties of sevoflurane in patients undergoing aortic valve replacement with cardiopulmonary bypass Anesth Analg 103 2006 289 296
35. S. Cromheecke, P.W. ten Broecke, and E. Hendrickx Incidence of atrial fibrillation early after cardiac surgery: Can choice of the anesthetic regimen influence the incidence? Acta Anaesthesiol Belg 56 2005 147 154
36. N.D. Nader, C.M. Li, and W.Z. Khadra Anesthetic myocardial protection with sevoflurane J Cardiothorac Vasc Anesth 18 2004 269 274
37. S.R. El Azab, P.M. Rosseel, and J.J. De Lange Effect of sevoflurane on the ex vivo secretion of TNF-alpha during and after coronary artery bypass surgery Eur J Anaesthesiol 20 2003 380 384
38. N.D. Nader, H.L. Karamanoukian, and R.L. Reedy Inclusion of sevoflurane in cardioplegia reduces neutrophil activity during cardiopulmonary bypass J Cardiothorac Vasc Anesth 20 2006 57 62
39. V. Yildirim, S. Doganci, and A. Aydin Cardioprotective effects of sevoflurane, isoflurane, and propofol in coronary surgery patients: A randomized controlled study Heart Surg Forum 12 2009 E1 E9
40. S.G. De Hert, P.J. Van der Linden, and S. Cromheecke Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration Anesthesiology 101 2004 299 310
41. S. Haroun-Bizri, S.S. Khoury, and I.R. Chehab Does isoflurane optimize myocardial protection during cardiopulmonary bypass? J Cardiothorac Vasc Anesth 15 2001 418 421
42. M. Meco, S. Cirri, and C. Gallazzi Desflurane preconditioning in coronary artery bypass graft surgery: A double-blind, randomised and placebo-controlled study Eur J Cardiothorac Surg 32 2007 319 325
43. K. Julier, R. da Silva, and C. Garcia Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: A double-blinded, placebo-controlled multicenter study Anesthesiology 98 2003 1315 1327
44. M. Zaugg, E. Lucchinetti, and D.R. Spahn Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways Anesthesiology 97 2002 4 14
45. ATP channels and reactive oxygen species Anesthesiology 100 2004 532 539
46. B. Bein, J. Renner, and D. Caliebe The effects of interrupted or continuous administration of sevoflurane on preconditioning before cardiopulmonary bypass in coronary artery surgery: Comparison with continuous propofol Anaesthesia 63 2008 1046 1055
47. J. Frassdorf, A. Borowski, and D. Ebel Impact of preconditioning protocol on anesthetic-induced cardioprotection in patients having coronary artery bypass surgery J Thorac Cardiovasc Surg 137 2009 1436 1442
48. C. Garcia, K. Julier, and L. Bestmann Preconditioning with sevoflurane decreases PECAM-1 expression and improves one-year cardiovascular outcome in coronary artery bypass graft surgery Br J Anaesth 94 2005 159 165
49. M.C. Lee, C.H. Chen, and M.C. Kuo Isoflurane preconditioning-induced cardio-protection in patients undergoing coronary artery bypass grafting Eur J Anaesthesiol 23 2006 841 847
50. Y.M. Amr, and I.M. Yassin Cardiac protection during on-pump coronary artery bypass grafting: Ischemic versus isoflurane preconditioning Semin Cardiothorac Vasc Anesth 14 2010 205 211
51. E. Kottenberg, M. Thielmann, and L. Bergman Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - A clinical trial Acta Anaesthesiol Scand 56 2012 30 38
52. P.F. Conzen, S. Fischer, and C. Detter Sevoflurane provides greater protection of the myocardium than propofol in patients undergoing off-pump coronary artery bypass surgery Anesthesiology 99 2003 826 833
53. F. Guarracino, G. Landoni, and L. Tritapepe Myocardial damage prevented by volatile anesthetics: A multicenter randomized controlled study J Cardiothorac Vasc Anesth 20 2006 477 483
54. B. Bein, J. Renner, and D. Caliebe Sevoflurane but not propofol preserves myocardial function during minimally invasive direct coronary artery bypass surgery Anesth Analg 100 2005 610 616
55. E. Lucchinetti, C. Hofer, and L. Bestmann Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: Inhalational versus intravenous anesthetics Anesthesiology 106 2007 444 457
56. B.G. Venketesh, Y. Mehta, and A. Kumar Comparison of sevoflurane and isoflurane in OPCAB surgery Ann Card Anesth 10 2007 46 50
57. T. Hemmerling, J.F. Olivier, and N. Le Myocardial protection by isoflurane vs. sevoflurane in ultra-fast-track anaesthesia for off-pump aortocoronary bypass grafting Eur J Anaesthesiol 25 2008 230 236
58. B. Pouzet, J.B. Lecharny, and M. Dehoux Is there a place for preconditioning during cardiac operations in humans? Ann Thorac Surg 73 2002 843 848
59. R. da Silva, T. Grampp, and T. Pasch Differential activation of mitogen-activated protein kinases in ischemic and anesthetic preconditioning Anesthesiology 100 2004 59 69
60. X. Wang, O. Jarvinen, and P. Kuukasjarvi Isoflurane produces only minor preconditioning in coronary artery bypass grafting Scand Cardiovasc J 38 2004 287 292
61. J.D. Law-Koune, C. Raynaud, and N. Liu Sevoflurane-remifentanil versus propofol-remifentanil anesthesia at a similar bispectral level for off-pump coronary artery surgery: No evidence of reduced myocardial ischemia J Cardiothorac Vasc Anesth 20 2006 484 492
62. T.Y. Kim, D.K. Kim, and T.G. Yoon Myocardial injury in remifentanil-based anaesthesia for off-pump coronary bypass surgery: An equipotent dose of sevoflurane versus propofol Anaesth Intensive Care 39 2011 418 425
63. I. Malagon, K. Hogenbirk, and J. van Pelt Effect of three different anaesthetic agents on the postoperative production of cardiac troponin T in paediatric cardic surgery Br J Anaesth 94 2005 805 809
64. V. Piriou, J. Mantz, and G. Goldfarb Sevoflurane preconditioning at 1 MAC only provides limited protection in patients undergoing coronary artery bypass surgery: A randomized bi-centre trial Br J Anaesth 99 2007 624 631
65. S. De Hert, D. Vlasselaers, and R. Barbe A comparison of volatile and non volatile agents for cardioprotection during on-pump coronary surgery Anaesthesia 64 2009 953 960
66. S. Flier, J. Post, and A.N. Concepcion Influence of propofol-opioid vs isoflurane-opioid anaesthesia on postoperative troponin release in patients undergoing coronary artery bypass grafting Br J Anaesth 105 2010 122 130
67. G.S. Murphy, J.W. Szokol, and J.H. Marymount Opioids and cardioprotection: The impact of morphine and fentanyl on recovery of ventricular function after cardiopulmonary bypass J Cardiothorac Vasc Anesth 20 2006 493 502
68. S. Lemoine, L. Zhu, and M. Massetti Continuous administration of remifentanil and sufentanil induces cardioprotection in human myocardium in vitro Acta Anaesthesiol Scand 55 2011 758 764
69. E. Bignami, G. Landoni, and C. Gerli Sevoflurane vs. propofol in patients with coronary artery disease undergoing mitral surgery: A randomised study Acta Anaesthesiol Scand 56 2012 482 490
70. G. Landoni, M.G. Calabro, and C. Marchetti Desflurane versus propofol in patients undergoing mitral valve surgery J Cardiothorac Vasc Anesth 21 2007 672 677
71. J.A. Symons, and P.S. Myles Myocardial protection with volatile anaesthetic agents during coronary artery bypass surgery: A meta-analysis Br J Anaesth 97 2006 127 136
72. C.H. Yu, and W.S. Beattie The effects of volatile anesthetics on cardiac ischemic complications and mortality in CABG: A meta-analysis Can J Anesth 53 2006 906 918
73. Bignami E, Greco T, Barile L, et al. The effect of isoflurane on survival and myocardial infarction: A meta-analysis of randomized controlled studies. J Cardiothorac Vasc Anesth 2012 (in Press)
74. K.J. Tuman, R.J. McCarthy, and B.D. Spiess Does choice of anesthetic agent significantly affect outcome after coronary artery surgery? Anesthesiology 70 1989 189 198
75. S. Slogoff, and A.S. Keats Randomized trial of primary anesthetic agents on outcome of coronary artery bypass operations Anesthesiology 70 1989 179 188
76. S. Slogoff, A.S. Keats, and W.E. Dear Steal-prone coronary anatomy and myocardial ischemia associated with four primary anesthetic agents in humans Anesth Analg 72 1991 22 27
77. K.J. Tuman, R.J. McCarthy, and B.D. Spiess Comparison of anesthetic techniques in patients undergoing heart valve replacement J Cardiothorac Anesth 4 1990 159 167
78. S. Reiz, and M. Ostman Regional coronary hemodynamics during isoflurane-nitrous oxide anesthesia in patients with ischemic heart disease Anesth Analg 64 1985 570 576
79. C.W. Buffington, K.B. Davis, and S. Gillispie The prevelance of steal-prone coronary anatomy in patients with coronary artery disease: An analysis of the Coronary Artery Surgery Study Registry Anesthesiology 69 1988 721 727
80. C.W. Buffington, J.L. Romson, and A. Levine Isoflurane induces coronary steal in a canine model of chronic coronary occlusion Anesthesiology 66 1987 280 292
81. G. Landoni, G.G. Biondi-Zoccai, and A. Zangrillo Desflurane and sevoflurane in cardiac surgery: A meta-analysis of randomized clinical trials J Cardiothorac Vasc Anesth 21 2007 502 511
82. E. Bignami, G. Biondi-Zoccai, and G. Landoni Volatile anesthetics reduce mortality in cardiac surgery J Cardiothorac Vasc Anesth 23 2009 594 599
83. C.J. Jakobsen, H. Berg, and K.B. Hindsholm The influence of propofol versus sevoflurane anesthesia on outcome in 10,535 cardiac surgical procedures J Cardiothorac Vasc Anesth 21 2007 664 671
84. A. Zangrillo, V. Testa, and V. Aldrovandi Volatile agents for cardiac protection in noncardiac surgery: A randomized controlled study J Cardiothorac Vasc Surg 25 2011 902 907
85. A.S. Bassuoni, and Y.M. Amr Cardioprotective effect of sevoflurane in patients with coronary artery disease undergoing vascular surgery Saudi J Anaesth 6 2012 125 130
86. L.A. Fleischer, J.A. Beckman, and K.A. Brown ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Writing Committee to revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): Developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery Circulation 116 2007 e418 e499
87. L.D. Hillis, P.K. Smith, and J.L. Anderson ACCF/AHA guideline for coronary bypass graft surgery: A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines Circulation 124 2011 e652 e735
88. P.S. Pagel Cardioprotection by volatile anesthetics: Established scientific principle or lingering clinical uncertainty? J Cardiothorac Vasc Anesth 23 2009 589 593
89. R. Sniecinski, and H. Liu Reduced efficacy of volatile anesthetic preconditioning with advanced age in isolated rat myocardium Anesthesiology 100 2004 589 597
90. L.T. Nguyen, M.J. Rebecchi, and L.C. Moore Attenuation of isoflurane-induced preconditioning and reactive oxygen species production in the senescent rat heart Anesth Analg 107 2008 776 782
91. Y. Mio, M.W. Bienengraeber, and J. Marinovic Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes. Roles for mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel activity Anesthesiology 108 2008 612 620
92. M.L. Riess, A.K. Camara, and S.S. Rhodes Increasing heart size and age attenuate anesthetic preconditioning in guinea pig isolated hearts Anesth Analg 101 2005 1572 1576
93. T. Song, L.Y. Lv, and J. Xu Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia-reperfusion injury: Role of AMP-activated protein kinase pathway Exp Biol Med (Maywood) 236 2011 1427 1436
94. K. Tanaka, F. Kehl, and W. Gu Isoflurane-induced preconditioning is attenuated by diabetes Am J Physiol Heart Circ Physiol 282 2002 H2018 H2023
95. J. Amour, A.K. Brzezinska, and Z. Jager Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms Anesthesiology 112 2010 576 585
96. A.A. Peivandi, M. Dahm, and U.T. Opfermann Comparison of cardiac troponin I versus T and creatine kinase MD after coronary artery bypass grafting in patients with and without perioperative myocardial infarction Herz 29 2004 658 664
97. S. Chia, F. Senatore, and O.C. Raffel Utility of cardiac biomarkers in predicting infarct size, left ventricular function, and clinical outcome after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction JACC Cardiovasc Interv 1 2008 415 423
98. M.B. Nienhuis, J.P. Ottervanger, and H.J. Bilo Prognostic value of troponin after elective percutaneous coronary intervention: A meta-analysis Catheter Cardiovasc Interv 71 2008 318 324
99. A.A. Mohammed, A.K. Agnihotri, and R.R. van Kimmenade Prospective, comprehensive assessment of cardiac troponin T testing after coronary artery bypass graft surgery Circulation 120 2009 843 850