Steroids for adult cardiac surgery with cardiopulmonary bypass: Update on dose and key randomized trials

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 27, Issue 5, 2013, Pages 1053-1059

  Murphy, Glenn S ^a   Whitlock, Richard P ^b   Gutsche, Jacob T ^c   Augoustides, John G T ^c  

^a NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; DEXAMETHASONE; HYDROCORTISONE; METHYLPREDNISOLONE; PLACEBO; STEROID;

ADULT; CARDIOPULMONARY BYPASS; HEART SURGERY; HUMAN; INFLAMMATION; LOW DRUG DOSE; PRIORITY JOURNAL; REVIEW;

ADULT; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; POSTOPERATIVE COMPLICATIONS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STEROIDS;

EID: 84884520844     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2013.04.022     Document Type: Review

References (44)

1. J.M. Dieleman, A.P. Nierich, and P.M. Rosseel Intraoperative high-dose dexamethasone for cardiac surgery: A randomized controlled trial JAMA 308 2012 1761 1767
2. P.A. Checchia, R.A. Bronicki, and J.M. Costello Steroid use before pediatric cardiac operations using cardiopulmonary bypass: An international survey of 36 centers Pediatr Crit Care Med 6 2005 441 444
3. M.A. Chaney Corticosteroids and cardiopulmonary bypass: A review of clinical investigations Chest 121 2002 921 931
4. K.M. Ho, and J.A. Tan Benefits and risks of corticosteroid prophylaxis in adult cardiac surgery: a dose-response meta-analysis Circulation 119 2009 1853 1866
5. J.G. Augoustides The inflammatory response to cardiac surgery with cardiopulmonary bypass: Should steroid prophylaxis be routine? J Cardiothoracic Vasc Anesth 26 2012 952 958
6. J.G. Augoustides Integrating outcome benefit into anesthetic design: The promise of steroids and statins J Cardiothorac Vasc Anesth 25 2011 880 884
7. J. Cremer, M. Martin, and H. Redl Systemic inflammatory response syndrome after cardiac operations Ann Thorac Surg 61 1996 1714 1720
8. K.H. Teoh, C.A. Bradley, and J. Gauldie Steroid inhibition of cytokine-mediated vasodilation after warm heart surgery Circulation 92 suppl 1995 II347 II353
9. A. Bourbon, M. Vionnet, and P. Leprince The effect of methylprednisolone treatment on the cardiopulmonary bypass-induced systemic inflammatory response Eur J Cardiothorac Surg 26 2004 932 938
10. M. Yilmaz, S. Ener, and H. Akalin Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation Perfusion 14 1999 201 206
11. R.P. Whitlock, E. Young, and J. Noora Pulse low dose steroids attenuate post-cardiopulmonary bypass SIRS; SIRS I J Surg Res 132 2006 188 194
12. E. Kilger, F. Weis, and J. Briegel Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Crit Care Med 31 2003 1068 1074
13. F. Weis, A. Beiras-Fernandez, and G. Schelling Stress doses of hydrocortisone in high-risk patients undergoing cardiac surgery: Effects on interleukin-6 to interleukin-10 ratio and early outcome Crit Care Med 37 2009 1685 1690
14. J.P. Yared, M.H. Bakri, and S.C. Erzurum Effect of dexamethasone on atrial fibrillation after cardiac surgery: Prospective, randomized, double-blind, placebo-controlled trial J Cardiothorac Vasc Anesth 21 2007 68 75
15. R.I. Hall, M.S. Smith, and G. Rocker The systemic inflammatory response to cardiopulmonary bypass: Pathophysiological, therapeutic, and pharmacological considerations Anesth Analg 85 1997 766 782
16. R. Hall Identification of inflammatory mediators and their modulation by strategies for the management of the systemic inflammatory response during cardiac surgery J Cardiothoracic Vasc Anesth 2013 [Epub ahead of print]
17. J. Halonen, P. Halonen, and O. Järvinen Corticosteroids for the prevention of atrial fibrillation after cardiac surgery: A randomized controlled trial JAMA 297 2007 1562 1567
18. C. Royse Epidurals for cardiac surgery: Can we substantially reduce surgical morbidity or should we focus on quality of recovery? Anesthesiology 114 2011 232 233
19. G.S. Murphy, J.W. Szokol, and S.B. Greenberg Preoperative dexamethasone enhances quality of recovery after laparoscopic cholecystectomy: Effect on in-hospital and postdischarge recovery outcomes Anesthesiology 114 2011 882 890
20. G.S. De Oliveira Jr, S. Ahmad, and P.C. Fitzgerald Dose ranging study on the effect of preoperative dexamethasone on postoperative quality of recovery and opioid consumption after ambulatory gynaecological surgery Br J Anaesth 107 2011 362 371
21. P. Halvorsen, J. Raeder, and P.F. White The effect of dexamethasone on side effects after coronary revascularization procedures Anesth Analg 96 2003 1578 1583
22. J.P. Yared, N.J. Starr, and L. Hoffmann-Hogg Dexamethasone decreases the incidence of shivering after cardiac surgery: A randomized, double-blind, placebo-controlled study Anesth Analg 87 1998 795 799
23. J.P. Yared, N.J. Starr, and F.K. Torres Effects of single dose, postinduction dexamethasone on recovery after cardiac surgery Ann Thorac Surg 69 2000 1420 1424
24. G.S. Murphy, S.S. Sherwani, and J.W. Szokol Small-dose dexamethasone improves quality of recovery scores after elective cardiac surgery: A randomized, double-blind, placebo-controlled study J Cardiothorac Vasc Anesth 25 2011 950 960
25. F. Weis, E. Kilger, and B. Roozendaal Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: A randomized study J Thorac Cardiovasc Surg 131 2006 277 282
26. R.P. Whitlock, S. Chan, and P.J. Devereaux Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: A meta-analysis of randomized trials Eur Heart J. 29 2008 2592 2600
27. G. Asimakopoulos, P.L. Smith, and C.P. Ratnatunga Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass Ann Thorac Surg 68 1999 1107 1115
28. E.M. Boyle Jr, T.H. Pohlman, and M.C. Johnson Endothelial cell injury in cardiovascular surgery: The systemic inflammatory response Ann Thorac Surg 63 1997 277 284
29. C.F. Mojcik, and J.H. Levy Aprotinin and the systemic inflammatory response after cardiopulmonary bypass Ann Thorac Surg 71 2001 745 754
30. J.K. Kirklin, S. Westaby, and E.H. Blackstone Complement and the damaging effects of cardiopulmonary bypass J Thorac Cardiovasc Surg 86 1983 845 857
31. M. Levi, M.E. Cromheecke, and E. de Jonge Pharmacological strategies to decrease excessive blood loss in cardiac surgery: A meta-analysis of clinically relevant endpoints Lancet 354 1999 1940 1947
32. D. Royston Preventing the inflammatory response to open-heart surgery: The role of aprotinin and other protease inhibitors Int J Cardiol 53 Suppl 1996 S11 S37
33. F.D. Rubens, and T. Mesana The inflammatory response to cardiopulmonary bypass: A therapeutic overview Perfusion 19 suppl 2004 S5 S12
34. S. Wan, J.L. LeClerc, and D. Schmartz Hepatic release of interleukin-10 during cardiopulmonary bypass in steroid-pretreated patients Am Heart J 133 1997 335 339
35. R.P. Whitlock, F.D. Rubens, and E. Young Pro: Steroids should be used for cardiopulmonary bypass J Cardiothorac Vasc Anesth 19 2005 250 254
36. R. Ascione, C.T. Lloyd, and M.J. Underwood Inflammatory response after coronary revascularization with or without cardiopulmonary bypass Ann Thorac Surg 69 2000 1198 1204
37. V. Gulielmos, M. Menschikowski, and H. Dill Interleukin-1, interleukin-6 and myocardial enzyme response after coronary artery bypass grafting - A prospective randomized comparison of the conventional and three minimally invasive surgical techniques Eur J Cardiothorac Surg 18 2000 594 601
38. S.M. Wildhirt, C. Schulze, and C. Schulz Reduction of systemic and cardiac adhesion molecule expression after off-pump versus conventional coronary artery bypass grafting Shock 16 suppl 2001 55 59
39. M.A. Chaney, M.P. Nikolov, and B. Blakeman Pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting and early tracheal extubation Anesth Analg 87 1998 27 33
40. M.A. Chaney, R.A. Durazo-Arvizu, and M.P. Nikolov Methylprednisolone does not benefit patients undergoing coronary artery bypass grafting and early tracheal extubation J Thorac Cardiovasc Surg 121 2001 561 569
41. R.M. Engelman, J.A. Rousou, and J.E. Flack Influence of steroids on complement and cytokine generation after cardiopulmonary bypass Ann Thorac Surg 60 1995 801 804
42. J.P. Gott, W.A. Cooper, and F.E. Schmidt Jr Modifying risk for extracorporeal circulation: Trial of four antiinflammatory strategies Ann Thorac Surg 66 1994 747 754
43. E.D. Verrier, S.K. Shernan, and K.M. Taylor Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial JAMA 291 2004 2319 2327
44. M.J. Domanski, K. Mahaffey, and V. Hasselblad Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery JAMA 305 2011 585 591