Predictive value of electrocardiographic T-wave morphology parameters and T-wave peak to T-wave end interval for sudden cardiac death in the general population

Circulation: Arrhythmia and Electrophysiology

Volumn 6, Issue 4, 2013, Pages 690-696

  Porthan, Kimmo ^a   Viitasalo, Matti ^a   Toivonen, Lauri ^a   Havulinna, Aki S ^b   Jula, Antti ^b   Tikkanen, Jani T ^c   Väänänen, Heikki ^d   Nieminen, Markku S ^a   Huikuri, Heikki V ^c   Newton Cheh, Christopher ^e,f   Salomaa, Veikko ^b   Oikarinen, Lasse ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d AALTO UNIVERSITY   (Finland)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Electrocardiography; Epidemiology; Prognosis; Repolarization; Sudden death

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CLINICAL ASSESSMENT; ELECTROCARDIOGRAPH; ELECTROCARDIOGRAPHY; FEMALE; FINLAND; FOLLOW UP; HEART REPOLARIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION; PREDICTION; PRIORITY JOURNAL; SUDDEN CARDIAC DEATH; T WAVE;

ELECTROCARDIOGRAPHY; EPIDEMIOLOGY; PROGNOSIS; REPOLARIZATION; SUDDEN DEATH;

ADULT; AGED; ARRHYTHMIAS, CARDIAC; DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY; FEMALE; FINLAND; HEART CONDUCTION SYSTEM; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PRINCIPAL COMPONENT ANALYSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; TIME FACTORS;

EID: 84884516819     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.113.000356     Document Type: Article

References (37)

1. Adabag AS, Luepker RV, Roger VL, Gersh BJ. Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol. 2010;7: 216-225.
2. Deo R, Albert CM. Epidemiology and genetics of sudden cardiac death. Circulation. 2012;125: 620-637.
3. Myerburg RJ, Junttila MJ. Sudden cardiac death caused by coronary heart disease. Circulation. 2012;125: 1043-1052.
4. Gaita F, Giustetto C, Bianchi F, Wolpert C, Schimpf R, Riccardi R, Grossi S, Richiardi E, Borggrefe M. Short QT Syndrome: a familial cause of sudden death. Circulation. 2003;108: 965-970.
5. Straus SM, Kors JA, De Bruin ML, van der Hooft CS, Hofman A, Heeringa J, Deckers JW, Kingma JH, Sturkenboom MC, Stricker BH, Witteman JC. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006;47: 362-367.
6. Panikkath R, Reinier K, Uy-Evanado A, Teodorescu C, Hattenhauer J, Mariani R, Gunson K, Jui J, Chugh SS. Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol. 2011;4: 441-447.
7. Okin PM, Devereux RB, Fabsitz RR, Lee ET, Galloway JM, Howard BV. Principal component analysis of the T wave and prediction of cardiovascular mortality in American Indians: the Strong Heart Study. Circulation. 2002;105: 714-719.
8. Okin PM, Malik M, Hnatkova K, Lee ET, Galloway JM, Best LG, Howard BV, Devereux RB. Repolarization abnormality for prediction of all-cause and cardiovascular mortality in American Indians: the Strong Heart Study. J Cardiovasc Electrophysiol. 2005;16: 945-951.
9. Zabel M, Malik M, Hnatkova K, Papademetriou V, Pittaras A, Fletcher RD, Franz MR. Analysis of T-wave morphology from the 12-lead electrocardiogram for prediction of long-term prognosis in male US veterans. Circulation. 2002;105: 1066-1070.
10. Kardys I, Kors JA, van der Meer IM, Hofman A, van der Kuip DA, Witteman JC. Spatial QRS-T angle predicts cardiac death in a general population. Eur Heart J. 2003;24: 1357-1364.
11. Rautaharju PM, Kooperberg C, Larson JC, LaCroix A. Electrocardiographic abnormalities that predict coronary heart disease events and mortality in postmenopausal women: the Women's Health Initiative. Circulation. 2006;113: 473-480.
12. Rautaharju PM, Kooperberg C, Larson JC, LaCroix A. Electrocardiographic predictors of incident congestive heart failure and all-cause mortality in postmenopausal women: the Women's Health Initiative. Circulation. 2006;113: 481-489.
13. Heistaro S. Methodology Report, Health 2000 Survey. Helsinki, Finland: KTL-National Public Health Institute; 2008. http://www.terveys2000.fi/ doc/methodologyrep.pdf. Accessed April 15, 2012.
14. Porthan K, Viitasalo M, Jula A, Reunanen A, Rapola J, Väänänen H, Nieminen MS, Toivonen L, Salomaa V, Oikarinen L. Predictive value of electrocardiographic QT interval and T-wave morphology parameters for all-cause and cardiovascular mortality in a general population sample. Heart Rhythm. 2009;6: 1202-8, 1208.e1.
15. Porthan K, Virolainen J, Hiltunen TP, Viitasalo M, Väänä nen H, Dabek J, Hannila-Handelberg T, Toivonen L, Nieminen MS, Kontula K, Oikarinen L. Relationship of electrocardiographic repolarization measures to echocardiographic left ventricular mass in men with hypertension. J Hypertens. 2007;25: 1951-1957.
16. Karjalainen J, Viitasalo M, Mänttäri M, Manninen V. Relation between QT intervals and heart rates from 40 to 120 beats/min in rest electrocardiograms of men and a simple method to adjust QT interval values. J Am Coll Cardiol. 1994;23: 1547-1553.
17. Okin PM, Devereux RB, Lee ET, Galloway JM, Howard BV; Strong Heart Study. Electrocardiographic repolarization complexity and abnormality predict all-cause and cardiovascular mortality in diabetes: the strong heart study. Diabetes. 2004;53: 434-440.
18. Acar B, Yi G, Hnatkova K, Malik M. Spatial, temporal and wavefront direction characteristics of 12-lead T-wave morphology. Med Biol Eng Comput. 1999;37: 574-584.
19. Malik M, Acar B, Gang Y, Yap YG, Hnatkova K, Camm AJ. QT dispersion does not represent electrocardiographic interlead heterogeneity of ventricular repolarization. J Cardiovasc Electrophysiol. 2000;11: 835-843.
20. Porthan K. Electrocardiographic Parameters of Ventricular Repolarization - Modifiers and the Prognostic Value. Helsinki, Finland: University of Helsinki 2011. https://helda.helsinki.fi/bitstream/handle/ 10138/26143/electroc.pdf? sequence=1. Accessed May 10, 2012.
21. Noseworthy PA, Havulinna AS, Porthan K, Lahtinen AM, Jula A, Karhunen PJ, Perola M, Oikarinen L, Kontula KK, Salomaa V, Newton- Cheh C. Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study. Circ Cardiovasc Genet. 2011;4: 305-311.
22. Blom G. Statistical Estimates and Transformed Beta Variables. New York: John Wiley & Sons, Inc. 1958.
23. Antolini L, Nam B-H, D'Agostino R. Inference on correlated discrimination measures in survival analysis: A nonparametric approach. Communications in Statistics - Theory and Methods. 2004;33: 2117-2135.
24. Heagerty PJ, Lumley T, Pepe MS. Time-dependent ROC curves for censored survival data and a diagnostic marker. Biometrics. 2000;56: 337-344.
25. Spaulding CM, Joly LM, Rosenberg A, Monchi M, Weber SN, Dhainaut JF, Carli P. Immediate coronary angiography in survivors of out-of-hospital cardiac arrest. N Engl J Med. 1997;336: 1629-1633.
26. Chugh SS. Early identification of risk factors for sudden cardiac death. Nat Rev Cardiol. 2010;7: 318-326.
27. Burgess MJ. Relation of ventricular repolarization to electrocardiographic T wave-form and arrhythmia vulnerability. Am J Physiol. 1979;236: H391-H402.
28. Cook NR. Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation. 2007;115: 928-935.
29. Antzelevitch C, Shimizu W, Yan GX, Sicouri S, Weissenburger J, Nesterenko VV, Burashnikov A, Di Diego J, Saffitz J, Thomas GP. The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol. 1999;10: 1124-1152.
30. Emori T, Antzelevitch C. Cellular basis for complex T waves and arrhythmic activity following combined I(Kr) and I(Ks) block. J Cardiovasc Electrophysiol. 2001;12: 1369-1378.
31. Xia Y, Liang Y, Kongstad O, Liao Q, Holm M, Olsson B, Yuan S. In vivo validation of the coincidence of the peak and end of the T wave with full repolarization of the epicardium and endocardium in swine. Heart Rhythm. 2005;2: 162-169.
32. Opthof T, Coronel R, Wilms-Schopman FJ, Plotnikov AN, Shlapakova IN, Danilo P Jr, Rosen MR, Janse MJ. Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion. Heart Rhythm. 2007;4: 341-348.
33. Van Huysduynen BH, Swenne CA, Draisma HH, Antoni ML, Van De Vooren H, Van Der Wall EE, Schalij MJ. Validation of ECG indices of ventricular repolarization heterogeneity: a computer simulation study. J Cardiovasc Electrophysiol. 2005;16: 1097-1103.
34. Kors JA, Ritsema van Eck HJ, van Herpen G. The meaning of the Tp-Te interval and its diagnostic value. J Electrocardiol. 2008;41: 575-580.
35. Smetana P, Schmidt A, Zabel M, Hnatkova K, Franz M, Huber K, Malik M. Assessment of repolarization heterogeneity for prediction of mortality in cardiovascular disease: peak to the end of the T wave interval and nondipolar repolarization components. J Electrocardiol. 2011;44: 301-308.
36. Smetana P, Batchvarov VN, Hnatkova K, Camm AJ, Malik M. Sex differences in repolarization homogeneity and its circadian pattern. Am J Physiol Heart Circ Physiol. 2002;282:H1889-H1897.
37. Surawicz B, Parikh SR. Differences between ventricular repolarization in men and women: description, mechanism and implications. Ann Noninvasive Electrocardiol. 2003;8: 333-340.