Cucurmosin induces the apoptosis of human pancreatic cancer CFPAC-1 cells by inactivating the PDGFR-β signalling pathway

Pharmacological Reports

Volumn 65, Issue 3, 2013, Pages 682-688

  Xie, Jieming ^a   Wang, Congfei ^a   Zhang, Baoming ^a   Yang, Aiqin ^a   Yin, Qiang ^a   Huang, Heguang ^a   Chen, Minghuang ^b  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER   (China)

Author keywords

Apoptosis; Cucurmosin; Pancreatic carcinoma; PDGFR; PI3K Akt mTOR

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CUCURMOSIN; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; P70S6K ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR GENE; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENOCARCINOMA; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CYSTIC FIBROSIS; DOWN-REGULATION; HUMANS; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84884489356     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/s1734-1140(13)71046-6     Document Type: Article

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