BK virus encephalitis: Case report, review of the literature, and description of a novel treatment modality

Annals of Pharmacotherapy

Volumn 47, Issue 9, 2013, Pages 1229-1233

  Chittick, Paul ^a   Williamson, John C ^b   Ohl, Christopher A ^b,c  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

^b WAKE FOREST BAPTIST HEALTH   (United States)

^c WAKE FOREST UNIVERSITY   (United States)

Author keywords

BK virus; Cidofovir; Cimetidine; Encephalitis in immunocompromised hosts

Indexed keywords

ANTINEOPLASTIC AGENT; CIDOFOVIR; CIMETIDINE; CORTICOSTEROID; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PROBENECID; TACROLIMUS;

ACUTE MYELOMONOCYTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIVIRAL THERAPY; ARTICLE; BK VIRUS; BK VIRUS INFECTION; CANCER CHEMOTHERAPY; CASE REPORT; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; CONFUSION; CORTICOSTEROID THERAPY; DIARRHEA; DRUG INDUCED DISEASE; EYE TOXICITY; FEVER; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN TISSUE; IATROGENIC DISEASE; IMMUNOSUPPRESSIVE TREATMENT; LEUKEMIA REMISSION; MALE; MULTIPLE ORGAN FAILURE; MYELODYSPLASTIC SYNDROME; NEPHROTOXICITY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PARANEOPLASTIC NEUROPATHY; PRIORITY JOURNAL; VIRUS ENCEPHALITIS;

BK VIRUS; CIDOFOVIR; CIMETIDINE; ENCEPHALITIS IN IMMUNOCOMPROMISED HOSTS;

ADULT; ANTIVIRAL AGENTS; BK VIRUS; CYTOSINE; ENCEPHALITIS; HUMANS; MALE; ORGANOPHOSPHONATES; POLYOMAVIRUS INFECTIONS; TUMOR VIRUS INFECTIONS;

EID: 84884473331     PISSN: 10600280     EISSN: 15426270     Source Type: Journal    
DOI: 10.1177/1060028013500646     Document Type: Article

References (36)

1. Seeley WW, Marty FM, Holmes TM, et al. Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology. 2007;69:156-165.
2. Kremer S, Matern JF, Bilger K, et al. EBV limbic encephalitis after allogeneic hematopoietic stem cell transplantation. J Neuroradiol. 2010;37:189-191.
3. Reddy SM, Winston DJ, Territo MC, Schiller GJ. CMV central nervous system disease in stem-cell transplant recipients: an increasing complication of drug-resistant CMV infection and protracted immunodeficiency. Bone Marrow Transplant. 2010;45:979-984.
4. Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis. 2003;3:611-623.
5. Vallbracht A, Lohler J, Gossman J, et al. Disseminated BK type polyomavirus infection in an AIDS patient associated with central nervous system disease. Am J Pathol. 1993;143:29-39.
6. Voltz R, Jager G, Seelos K, Fuhry L, Hohlfeld R. BK virus encephalitis in an immunocompetent patient. Arch Neurol. 1996;53:101-103.
7. Bratt G, Hammarin AL, Grandien M, et al. BK virus as the cause of meningoencephalitis, retinitis and nephritis in a patient with AIDS. AIDS. 1999;13:1071-1075.
8. Lesprit P, Chaline-Lehmann D, Authier FJ, Ponnelle T, Gray F, Levy Y. BK virus encephalitis in a patient with AIDS and lymphoma. AIDS. 2001;15:1196-1199.
9. Stoner GL, Alappan R, Jobes DV, Ryschkewitsch CF, Landry ML. BK virus regulatory region rearrangements in brain and cerebrospinal fluid from a leukemia patient with tubulointerstitial nephritis and meningoencephalitis. Am J Kidney Dis. 2002;39:1102-1112.
10. Behzad-Behbahani A, Klapper PE, Vallely PJ, Cleator GM. BK virus DNA in CSF of immunocompetent and immunocompromised patients. Arch Dis Child. 2003;88:174-175.
11. Behzad-Behbahani A, Klapper PE, Vallely PJ, Cleator GM, Bonington A. BKV-DNA and JCV-DNA in CSF of patients with suspected meningitis or encephalitis. Infection. 2003;31:374-378.
12. Hix JK, Braun WE, Isada CM. Delirium in a renal transplant recipient associated with BK virus in the cerebrospinal fluid. Transplantation. 2004;78:1407-1408.
13. Friedman DP, Flanders AE. MR imaging of BK virus encephalitis. AJNR Am J Neuroradiol. 2006;27:1016-1018.
14. Vidal JE, Fink MC, Cedeno-Laurent F, et al. BK virus associated meningoencephalitis in an AIDS patient treated with HAART. AIDS Res Ther. 2007;4:13.
15. Ferrari A, Luppi M, Marasca R, et al. BK virus infection and neurologic dysfunctions in a patient with lymphoma treated with rituximab. Eur J Haematol. 2008;81:244-245.
16. Behre G, Becker M, Christopeit M. BK virus encephalitis in an allogeneic hematopoietic stem cell recipient [letter]. Bone Marrow Transplant. 2008;42:499.
17. Lopes da Silva R, Ferreira I, Teixeira G, et al. BK virus encephalitis with thrombotic microangiopathy in an allogeneic hematopoietic stem cell transplant recipient. Transpl Infect Dis. 2011;13:161-167.
18. Pereira T, Rojas CP, Garcia-Buitrago MT, et al. A child with BK virus infection: inadequacy of current therapeutic strategies. Pediatr Transplant. 2012;16:E269-E274.
19. Tan CS, Koralnik IJ. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010;9:425-437.
20. Elsner C, Dorries K. Evidence of human polyomavirus BK and JC infection in normal brain tissue. Virology. 1992;191:72-80.
21. Vago L, Cinque P, Sala E, et al. JCV-DNA and BKV-DNA in the CNS tissue and CSF of AIDS patients and normal subjects: study of 41 cases and review of the literature. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;12:139-146.
22. Jorgensen GE, Hammarin AL, Bratt G, Grandien M, Flaegstad T, Johnsen JI. Identification of a unique BK virus variant in the CNS of a patient with AIDS. J Med Virol. 2003;70:14-19.
23. Barcena-Panero A, Echevarria JE, Van Ghelue M, et al. BK polyomavirus with archetypal and rearranged non-coding control regions is present in cerebrospinal fluids from patients with neurological complications. J Gen Virol. 2012;93:1780-1794.
24. Leung AY, Chan MT, Yuen KY, et al. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2005;40:528-537.
25. Sener A, House AA, Jevnikar AM, et al. Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipients. Transplantation. 2006;81:117-120.
26. Wu JK, Harris MT. Use of leflunomide in the treatment of polyomavirus BK-associated nephropathy. Ann Pharmacother. 2008;42:1679-1685. doi:10.1345/aph.1L180.
27. Ganguly N, Clough LA, Dubois LK, et al. Low-dose cidofovir in the treatment of symptomatic BK virus infection in patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis of an algorithmic approach. Transpl Infect Dis. 2010;12:406-411.
28. Kuypers DR, Bammens B, Claes K, Evenepoel P, Lerut E, Vanrenterghem Y. A single-centre study of adjuvant cidofovir therapy for BK virus interstitial nephritis (BKVIN) in renal allograft recipients. J Antimicrob Chemother. 2009;63:417-419.
29. Cesaro S, Hirsch HH, Faraci M, et al. Cidofovir for BK virus-associated hemorrhagic cystitis: a retrospective study. Clin Infect Dis. 2009;49:233-240.
30. Vistide (cidofovir injection) [prescribing information]. Foster City, CA: Gilead; 2010. http://www.gilead.com/pdf/vistide. pdf. Accessed January 31, 2013.
31. Pohlmann C, Schetelig J, Reuner U, et al. Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient. Clin Infect Dis. 2007;44:e118-e120.
32. Burckhardt BC, Brai S, Wallis S, Krick W, Wolff NA, Burckhardt G. Transport of cimetidine by flounder and human renal organic anion transporter 1. Am J Physiol Renal Physiol. 2003;284:503-509.
33. Wang J, Nation RL, Evans AM, Cox S. Renal secretion of the antiviral nucleoside analog AM188 is inhibited by probenecid, p-aminohippuric acid, and cimetidine in the isolated perfused rat kidney. Pharm Res. 2004;21:982-988.
34. De Bony F, Tod M, Bidault R, On NT, Posner J, Rolan P. Multiple interactions of cimetidine and probenecid with valacyclovir and its metabolite acyclovir. Antimicrob Agents Chemother. 2002;46:458-463.
35. Cimetidine (cimetidine hydrochloride injection, solution) [prescribing information]. 2006. http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id%20=%2047776. Accessed March 25, 2013.
36. Probenecid (probenecid tablet, film coated) [prescribing information]. June 2010. http://dailymed.nlm.nih.gov/dailymed/Lookup.cfm?setid%20=%20ae126418-5474-4fbeb83c-bde8b2b4ae6e. Accessed March 25, 2013.