Micro-CT evaluation of bone defects: Applications to osteolytic bone metastases, bone cysts, and fracture

Medical Engineering and Physics

Volumn 35, Issue 11, 2013, Pages 1645-1650

  Buie, Helen R ^a,c   Bosma, Nick A ^b,c   Downey, Charlene M ^b,c   Jirik, Frank R ^b,c   Boyd, Steven K ^a,c  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Analysis techniques; Bone; Defect; Micro CT; Microarchitecture; Morphology

Indexed keywords

ANALYSIS TECHNIQUES; HOMOGENEOUS STRUCTURE; IMAGING TECHNOLOGY; MICRO ARCHITECTURES; MICRO CT; QUANTITATIVE APPROACH; QUANTITATIVE EVALUATION; SPACING STANDARDS;

COMPUTER ARCHITECTURE; COMPUTERIZED TOMOGRAPHY; DEFECTS; MAMMALS; MORPHOLOGY; PATHOLOGY; QUALITY CONTROL;

BONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLUMINESCENCE; BONE CYST; BONE DEFECT; BONE METASTASIS; BONE STRUCTURE; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; CORTICAL BONE; DIAGNOSTIC IMAGING; DISEASE SEVERITY; FEMALE; FRACTURE HEALING; HUMAN; HUMAN CELL; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING; TIBIA; TRABECULAR BONE; TUMOR VOLUME;

ANALYSIS TECHNIQUES; BMD; BONE; BONE MINERAL DENSITY; BONE VOLUME FRACTION; BV/TV; CONND; CONNECTIVITY DENSITY; DEFECT; MICRO-CT; MICROARCHITECTURE; MORPHOLOGY; SP; SP(MAX); SPACING; SPACING MAXIMUM; SPACING STANDARD DEVIATION; SPSD; TH; THICKNESS; THICKNESS STANDARD DEVIATION; THSD;

ANIMALS; BONE AND BONES; BONE CYSTS; BONE NEOPLASMS; CELL LINE, TUMOR; FEMALE; FRACTURE HEALING; FRACTURES, BONE; HUMANS; MICE; NEOPLASM METASTASIS; OSTEOLYSIS; TUMOR BURDEN; X-RAY MICROTOMOGRAPHY;

EID: 84884413806     PISSN: 13504533     EISSN: 18734030     Source Type: Journal    
DOI: 10.1016/j.medengphy.2013.05.016     Document Type: Article

References (17)

1. Anderson T.L. Linear elastic fracture mechanics. Fracture mechanics: fundamentals and applications 2005, 31-116. Taylor & Francis, Boca Raton, USA.
2. Wallach J.C., Gibson L.J. Defect sensitivity of a 3D truss material. Scripta Mater 2001, 45:639-644.
3. Buie H.R., Boyd S.K., Pilkey K.A. A parametric study of trabecular architecture versus mechanical properties using finite element and rapid prototyping techniques. 31st American Society of Bone and Mineral Research Annual Meeting 2009, S241. J Bone Miner Res, Denver, USA.
4. Nazarian A., Stauber M., Zurakowski D., Snyder B.D., Muller R. The interaction of microstructure and volume fraction in predicting failure in cancellous bone. Bone 2006, 39:1196-1202.
5. Mundy G.R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002, 2:584-593.
6. Missbach-Guentner J., Dullin C., Zientkowska M., Domeyer-Missbach M., Kimmina S., Obenauer S., et al. Flat-panel detector-based volume computed tomography: a novel 3D imaging technique to monitor osteolytic bone lesions in a mouse tumor metastasis model. Neoplasia 2007, 9:755-765.
7. Arrington S.A., Schoonmaker J.E., Damron T.A., Mann K.A., Allen M.J. Temporal changes in bone mass and mechanical properties in a murine model of tumor osteolysis. Bone 2006, 38:359-367.
8. Gasser J.A., Ingold P., Grosios K., Laib A., Hammerle S., Koller B. Noninvasive monitoring of changes in structural cancellous bone parameters with a novel prototype micro-CT. J Bone Miner Metab 2005, 23(Suppl.):90-96.
9. Kurth A.A., Muller R. The effect of an osteolytic tumor on the three-dimensional trabecular bone morphology in an animal model. Skeletal Radiol 2001, 30:94-98.
10. Buie H.R., Moore C.P., Boyd S.K. Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice. J Bone Miner Res 2008, 23:2048-2059.
11. Fritz V., Louis-Plence P., Apparailly F., Noel D., Voide R., Pillon A., et al. Micro-CT combined with bioluminescence imaging: a dynamic approach to detect early tumor-bone interaction in a tumor osteolysis murine model. Bone 2007, 40:1032-1040.
12. Taiani J.T., Krawetz R.J., Yamashita A., Pauchard Y., Buie H.R., Ponjevic D., et al. Embryonic stem cells contribute to bone formation in an immunocompetent mouse fracture model. Cell Transplant 2012, [ePub]. 10.3727/096368912X658755.
13. Bondareva A., Downey C.M., Ayres F., Liu W., Boyd S.K., Hallgrìmsson B., et al. The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells. PLoS ONE 2009, 4:e5620.
14. Hildebrand T., Rüegsegger P. A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc 1997, 185:67-75.
15. Odgaard A., Gundersen H.J. Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone 1993, 14:173-182.
16. Nishiyama K.K., Campbell G.M., Klinck R.J., Boyd S.K. Reproducibility of bone micro-architecture measurements in rodents by in vivo micro-computed tomography is maximized with three-dimensional image registration. Bone 2010, 46:155-161.
17. Buie H.R., Campbell G.M., Klinck R.J., MacNeil J.A., Boyd S.K. Automatic segmentation based on a dual threshold technique for in vivo micro-CT bone analysis. Bone 2007, 41:505-515.