메뉴 건너뛰기




Volumn 7, Issue , 2013, Pages 1849-1858

Real-world variability in ranibizumab treatment and associated clinical, quality of life, and safety outcomes over 24 months in patients with neovascular age-related macular degeneration: The HELIOS study

Author keywords

Age related macular degeneration; Neovascular macular degeneration; Quality of life; Ranibizumab; Visual acuity; Visual function

Indexed keywords

BEVACIZUMAB; CORTICOSTEROID; PEGAPTANIB; RANIBIZUMAB;

EID: 84884409168     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: 10.2147/OPTH.S49385     Document Type: Article
Times cited : (61)

References (29)
  • 1
    • 11144357411 scopus 로고    scopus 로고
    • Methods for a population-based study of the prevalence of and risk factors for age-related maculopathy and macular degeneration in elderly European populations: The EUREYE study
    • Augood C, Fletcher A, Bentham G, et al. Methods for a population-based study of the prevalence of and risk factors for age-related maculopathy and macular degeneration in elderly European populations: the EUREYE study. Ophthalmic Epidemiol. 2004;11(2):117-129.
    • (2004) Ophthalmic Epidemiol , vol.11 , Issue.2 , pp. 117-129
    • Augood, C.1    Fletcher, A.2    Bentham, G.3
  • 2
    • 1942542429 scopus 로고    scopus 로고
    • Age-related macular degeneration is the leading cause of blindness
    • Bressler NM. Age-related macular degeneration is the leading cause of blindness. JAMA. 2004;291(15):1900-1901.
    • (2004) JAMA , vol.291 , Issue.15 , pp. 1900-1901
    • Bressler, N.M.1
  • 3
    • 11144354339 scopus 로고    scopus 로고
    • Prevalence of age-related macular degeneration in the United States
    • Eye Diseases Prevalence Research Group
    • Friedman DS, O'Colmain BJ, Muñoz B, et al; Eye Diseases Prevalence Research Group. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004;122(4):564-572.
    • (2004) Arch Ophthalmol , vol.122 , Issue.4 , pp. 564-572
    • Friedman, D.S.1    O'Colmain, B.J.2    Muñoz, B.3
  • 4
  • 5
    • 77958599577 scopus 로고    scopus 로고
    • Ranibizumab therapy for neovascular age-related macular degeneration
    • Folk JC, Stone EM. Ranibizumab therapy for neovascular age-related macular degeneration. N Engl J Med. 2010;363(17):1648-1655.
    • (2010) N Engl J Med , vol.363 , Issue.17 , pp. 1648-1655
    • Folk, J.C.1    Stone, E.M.2
  • 6
    • 79955623054 scopus 로고    scopus 로고
    • Prevalence of age-related macular degeneration in old persons: Age, gene/environment Susceptibility Reykjavik Study
    • Jonasson F, Arnarsson A, Eiríksdottir G, et al. Prevalence of age-related macular degeneration in old persons: age, gene/environment Susceptibility Reykjavik Study. Ophthalmology. 2011;118(5):825-830.
    • (2011) Ophthalmology , vol.118 , Issue.5 , pp. 825-830
    • Jonasson, F.1    Arnarsson, A.2    Eiríksdottir, G.3
  • 7
    • 37449010146 scopus 로고    scopus 로고
    • The natural history and prognosis of neovascular age-related macular degeneration: A systematic review of the literature and meta-analysis
    • Wong TY, Wong T, Chakravarthy U, et al. The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis. Ophthalmology. 2008;115(1):116-126.
    • (2008) Ophthalmology , vol.115 , Issue.1 , pp. 116-126
    • Wong, T.Y.1    Wong, T.2    Chakravarthy, U.3
  • 8
    • 16244368037 scopus 로고    scopus 로고
    • Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no 19
    • Age-Related Eye Disease Study Research Group
    • Clemons TE, Milton RC, Klein R, Seddon JM, Ferris FL; Age-Related Eye Disease Study Research Group. Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no 19. Ophthalmology. 2005;112(4):533-539.
    • (2005) Ophthalmology , vol.112 , Issue.4 , pp. 533-539
    • Clemons, T.E.1    Milton, R.C.2    Klein, R.3    Seddon, J.M.4    Ferris, F.L.5
  • 9
    • 0037230255 scopus 로고    scopus 로고
    • Quality of life with macular degeneration: Perceptions of patients, clinicians, and community members
    • Stein JD, Brown MM, Brown GC, Hollands H, Sharma S. Quality of life with macular degeneration: perceptions of patients, clinicians, and community members. Br J Ophthalmol. 2003;87(1):8-12.
    • (2003) Br J Ophthalmol , vol.87 , Issue.1 , pp. 8-12
    • Stein, J.D.1    Brown, M.M.2    Brown, G.C.3    Hollands, H.4    Sharma, S.5
  • 10
    • 79960190528 scopus 로고    scopus 로고
    • Psychological and cognitive determinants of vision function in age-related macular degeneration
    • Study
    • Rovner BW, Casten RJ, Massof RW, Leiby BE, Tasman WS; Wills Eye AMD Study. Psychological and cognitive determinants of vision function in age-related macular degeneration. Arch Ophthalmol. 2011;129(7):885-890.
    • (2011) Arch Ophthalmol , vol.129 , Issue.7 , pp. 885-890
    • Rovner, B.W.1    Casten, R.J.2    Massof, R.W.3    Leiby, B.E.4    Tasman, W.S.5    Wills, E.A.M.D.6
  • 11
    • 4344594704 scopus 로고    scopus 로고
    • Reduced vision in older adults with age related macular degeneration interferes with ability to care for self and impairs role as carer
    • Stevenson MR, Hart PM, Montgomery AM, McCulloch DW, Chakravarthy U. Reduced vision in older adults with age related macular degeneration interferes with ability to care for self and impairs role as carer. Br J Ophthalmol. 2004;88(9):1125-1130.
    • (2004) Br J Ophthalmol , vol.88 , Issue.9 , pp. 1125-1130
    • Stevenson, M.R.1    Hart, P.M.2    Montgomery, A.M.3    McCulloch, D.W.4    Chakravarthy, U.5
  • 12
    • 57949094834 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    • ANCHOR Study Group
    • Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T; ANCHOR Study Group. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study. Ophthalmology. 2009;116(1):57-65. e5.
    • (2009) Ophthalmology , vol.116 , Issue.1
    • Brown, D.M.1    Michels, M.2    Kaiser, P.K.3    Heier, J.S.4    Sy, J.P.5    Ianchulev, T.6
  • 13
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • MARINA Study Group
    • Rosenfeld PJ, Brown DM, Heier JS, et al; MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355(14):1419-1431.
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 14
    • 77956056292 scopus 로고    scopus 로고
    • Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2
    • Abraham P, Yue H, Wilson L. Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2. Am J Ophthalmol. 2010;150(3):315-324. e1.
    • (2010) Am J Ophthalmol , vol.150 , Issue.3
    • Abraham, P.1    Yue, H.2    Wilson, L.3
  • 15
    • 67149101784 scopus 로고    scopus 로고
    • A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: Year 2 of the PrONTO Study
    • Lalwani GA, Rosenfeld PJ, Fung AE, et al. A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study. Am J Ophthalmol. 2009;148(1):43-58. e1.
    • (2009) Am J Ophthalmol , vol.148 , Issue.1
    • Lalwani, G.A.1    Rosenfeld, P.J.2    Fung, A.E.3
  • 16
    • 79955615679 scopus 로고    scopus 로고
    • Retreatment criteria in anti-VEGF therapy of exudative AMD: Critical analysis of present regimes and new morphological definition of "lesion activity"
    • Pauleikhoff D, Kirchhof B. Retreatment criteria in anti-VEGF therapy of exudative AMD: critical analysis of present regimes and new morphological definition of "lesion activity". Graefes Arch Clin Exp Ophthalmol. 2011;249(5):631-632.
    • (2011) Graefes Arch Clin Exp Ophthalmol , vol.249 , Issue.5 , pp. 631-632
    • Pauleikhoff, D.1    Kirchhof, B.2
  • 17
    • 84884385591 scopus 로고    scopus 로고
    • Rijksinstituut voor Ziekteen Invaliditeitsverzekering, [Eligibility of the specialty Lucentis]. Available at, Accessed on 22 July, German
    • Rijksinstituut voor Ziekteen Invaliditeitsverzekering. Vergoed-baarheid van de specialiteit Lucentis. [Eligibility of the specialty Lucentis]. Available at: http://www.riziv.fgov.be/inami_prd/ssp/cns2/pages/MinisterialDecisionDet.asp?qs_SpcCod=00643937&qs_EffDat=20071101&qs_MdId=4852. Accessed on 22 July 2013. German.
    • (2013) Vergoed-baarheid Van De Specialiteit Lucentis
  • 18
    • 0031797859 scopus 로고    scopus 로고
    • Psychometric properties of the National Eye Institute Visual Function Questionnaire (NEI-VFQ). NEI-VFQ Field Test Investigators
    • Mangione CM, Lee PP, Pitts J, Gutierrez P, Berry S, Hays RD. Psychometric properties of the National Eye Institute Visual Function Questionnaire (NEI-VFQ). NEI-VFQ Field Test Investigators. Arch Ophthalmol. 1998;116(11):1496-1504.
    • (1998) Arch Ophthalmol , vol.116 , Issue.11 , pp. 1496-1504
    • Mangione, C.M.1    Lee, P.P.2    Pitts, J.3    Gutierrez, P.4    Berry, S.5    Hays, R.D.6
  • 19
    • 0034945828 scopus 로고    scopus 로고
    • Development of the 25-item National Eye Institute Visual Function Questionnaire
    • National Eye Institute Visual Function Questionnaire Field Test Investigators
    • Mangione CM, Lee PP, Gutierrez PR, Spritzer K, Berry S, Hays RD; National Eye Institute Visual Function Questionnaire Field Test Investigators. Development of the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol. 2001;119(7):1050-1058.
    • (2001) Arch Ophthalmol , vol.119 , Issue.7 , pp. 1050-1058
    • Mangione, C.M.1    Lee, P.P.2    Gutierrez, P.R.3    Spritzer, K.4    Berry, S.5    Hays, R.D.6
  • 20
    • 0037314160 scopus 로고    scopus 로고
    • National Eye Institute Visual Function Questionnaire in the Age-Related Eye Disease Study (AREDS): AREDS Report No 10
    • Age-Related Eye Disease Study Research Group
    • Clemons TE, Chew EY, Bressler SB, McBee W; Age-Related Eye Disease Study Research Group. National Eye Institute Visual Function Questionnaire in the Age-Related Eye Disease Study (AREDS): AREDS Report No 10. Arch Ophthalmol. 2003;121(2):211-217.
    • (2003) Arch Ophthalmol , vol.121 , Issue.2 , pp. 211-217
    • Clemons, T.E.1    Chew, E.Y.2    Bressler, S.B.3    McBee, W.4
  • 21
    • 80051570440 scopus 로고    scopus 로고
    • Validation of the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) in age-related macular degeneration
    • Orr P, Rentz AM, Margolis MK, et al. Validation of the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52(6): 3354-3359.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , Issue.6 , pp. 3354-3359
    • Orr, P.1    Rentz, A.M.2    Margolis, M.K.3
  • 22
    • 68349113753 scopus 로고    scopus 로고
    • Responsiveness of NEI VFQ-25 to changes in visual acuity in neovascular AMD: Validation studies from two phase 3 clinical trials
    • Suñer IJ, Kokame GT, Yu E, Ward J, Dolan C, Bressler NM. Responsiveness of NEI VFQ-25 to changes in visual acuity in neovascular AMD: validation studies from two phase 3 clinical trials. Invest Ophthalmol Vis Sci. 2009;50(8):3629-3635.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.8 , pp. 3629-3635
    • Suñer, I.J.1    Kokame, G.T.2    Yu, E.3    Ward, J.4    Dolan, C.5    Bressler, N.M.6
  • 23
    • 3042545839 scopus 로고    scopus 로고
    • The Health Utilities Index (HUI): Concepts, measurement properties and applications
    • Horsman J, Furlong W, Feeny D, Torrance G. The Health Utilities Index (HUI): concepts, measurement properties and applications. Health Qual Life Outcomes. 2003;1:54.
    • (2003) Health Qual Life Outcomes , vol.1 , pp. 54
    • Horsman, J.1    Furlong, W.2    Feeny, D.3    Torrance, G.4
  • 24
    • 2442438990 scopus 로고    scopus 로고
    • Age-related macular degeneration and quality of life: How to interpret a research paper in health-related quality of life
    • Sharma S, Oliver-Fernandez A. Age-related macular degeneration and quality of life: how to interpret a research paper in health-related quality of life. Curr Opin Ophthalmol. 2004;15(3):227-231.
    • (2004) Curr Opin Ophthalmol , vol.15 , Issue.3 , pp. 227-231
    • Sharma, S.1    Oliver-Fernandez, A.2
  • 25
    • 0008348082 scopus 로고    scopus 로고
    • European Medicines Agency. Available from, Accessed July 22
    • European Medicines Agency. European Public Assessment Report Lucentis. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000715/WC500043546.pdf. Accessed July 22, 2013.
    • (2013) European Public Assessment Report Lucentis
  • 26
    • 79956218863 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for neovascular age-related macular degeneration
    • CATT Research Group
    • CATT Research Group, Martin DF, Maguire MG, et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;364(20):1897-1908. et al.
    • (2011) N Engl J Med , vol.364 , Issue.20 , pp. 1897-1908
    • Martin, D.F.1    Maguire, M.G.2
  • 27
    • 84877759606 scopus 로고    scopus 로고
    • Twelve-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration
    • HARBOR Study Group
    • Busbee BG, Ho AC, Brown DM, Heier JS, Suner IJ, Li Z, Rubio RG, Lai P; HARBOR Study Group. Twelve-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration. Opthalmology. 2013;120(5):1046-56.
    • (2013) Opthalmology , vol.120 , Issue.5 , pp. 1046-1056
    • Busbee, B.G.1    Ho, A.C.2    Brown, D.M.3    Heier, J.S.4    Suner, I.J.5    Li, Z.6    Rubio, R.G.7    Lai, P.8
  • 28
    • 84884361415 scopus 로고    scopus 로고
    • Special Eurobarometer 332. Tobacco. Brussels, Belgium: European Commission, Available from, Accessed June 20, 2013
    • TNS Opinion and Social. Special Eurobarometer 332. Tobacco. Brussels, Belgium: European Commission; 2010. Available from: http://ec.europa.eu/health/tobacco/docs/ebs332_en.pdf. Accessed June 20, 2013.
    • (2010) TNS Opinion and Social


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.