Paradoxical effect of obesity on hemorrhagic transformation after acute ischemic stroke

BMC Neurology

Volumn 13, Issue , 2013, Pages

  Kim, Chi Kyung ^a   Ryu, Wi Sun ^b   Kim, Beom Joon ^c   Lee, Seung Hoon ^a  

^a Seoul National University Hospital   (South Korea)

^b Dongguk University Ilsan Hospital   (South Korea)

^c Seoul National University Bundang Hospital   (South Korea)

Author keywords

Bleeding obesity paradox; Body mass index; Hemorrhagic transformation; Ischemic stroke; Obesity

Indexed keywords

ADULT; AGED; ARTICLE; BLEEDING DISORDER; BODY MASS; BODY WEIGHT; BRAIN ISCHEMIA; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FOLLOW UP; HEMORRHAGIC TRANSFORMATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; OUTCOME ASSESSMENT; RISK ASSESSMENT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; CHI-SQUARE DISTRIBUTION; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBESITY; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STROKE; YOUNG ADULT;

EID: 84884401522     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/1471-2377-13-123     Document Type: Article

References (25)

1. Okada Y, Yamaguchi T, Minematsu K, Miyashita T, Sawada T, Sadoshima S, Fujishima M, Omae T. Hemorrhagic transformation in cerebral embolism. Stroke 1989, 20:598-603. 10.1161/01.STR.20.5.598, 2718199.
2. Larrue V, von Kummer RR, Muller A, Bluhmki E. Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke 2001, 32:438-441. 10.1161/01.STR.32.2.438, 11157179.
3. Dzialowski I, Pexman JH, Barber PA, Demchuk AM, Buchan AM, Hill MD. Asymptomatic hemorrhage after thrombolysis may not be benign: prognosis by hemorrhage type in the Canadian alteplase for stroke effectiveness study registry. Stroke 2007, 38:75-79. 10.1161/01.STR.0000251644.76546.62, 17122437.
4. Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004, 363:768-774.
5. Castellanos M, Leira R, Serena J, Pumar JM, Lizasoain I, Castillo J, Davalos A. Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke 2003, 34:40-46. 10.1161/01.STR.0000046764.57344.31, 12515281.
6. Larrue V, von Kummer R, del Zoppo G, Bluhmki E. Hemorrhagic transformation in acute ischemic stroke. Potential contributing factors in the European Cooperative Acute Stroke Study. Stroke 1997, 28:957-960. 10.1161/01.STR.28.5.957, 9158632.
7. Haslam DW, James WP. Obesity. Lancet 2005, 366:1197-1209. 10.1016/S0140-6736(05)67483-1, 16198769.
8. Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 2009, 53:1925-1932. 10.1016/j.jacc.2008.12.068, 19460605.
9. Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, Mookadam F, Lopez-Jimenez F. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 2006, 368:666-678. 10.1016/S0140-6736(06)69251-9, 16920472.
10. Delhaye C, Wakabayashi K, Maluenda G, Belle L, Ben-Dor I, Gonzalez MA, Gaglia MA, Torguson R, Xue Z, Suddath WO, et al. Body mass index and bleeding complications after percutaneous coronary intervention: does bivalirudin make a difference?. Am Heart J 2010, 159:1139-1146. 10.1016/j.ahj.2010.03.011, 20569731.
11. Wang X, Lo EH. Triggers and mediators of hemorrhagic transformation in cerebral ischemia. Mol Neurobiol 2003, 28:229-244. 10.1385/MN:28:3:229, 14709787.
12. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993, 24:35-41. 10.1161/01.STR.24.1.35, 7678184.
13. World Health Organization International Obesity Task Force International Association for the Study of Obesity, the Asia-Pacific Perspective: Redefining Obesity and its Treatment 2000, Sydney: Health Communications, World Health Organization International Obesity Task Force.
14. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, Boysen G, Bluhmki E, Hoxter G, Mahagne MH, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 1995, 274:1017-1025. 10.1001/jama.1995.03530130023023, 7563451.
15. Fazekas F, Niederkorn K, Schmidt R, Offenbacher H, Horner S, Bertha G, Lechner H. White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke 1988, 19:1285-1288. 10.1161/01.STR.19.10.1285, 3051534.
16. Lee SH, Kwon SJ, Kim KS, Yoon BW, Roh JK. Cerebral microbleeds in patients with hypertensive stroke. Topographical distribution in the supratentorial area. J Neurol 2004, 251:1183-1189. 10.1007/s00415-004-0500-6, 15503095.
17. Biffi A, Greenberg SM. Cerebral amyloid angiopathy: a systematic review. J Clin Neurol 2011, 7:1-9. 3079153, 21519520.
18. Olsen TS, Dehlendorff C, Petersen HG, Andersen KK. Body mass index and poststroke mortality. Neuroepidemiology 2008, 30:93-100. 10.1159/000118945, 18309248.
19. Towfighi A, Ovbiagele B. The impact of body mass index on mortality after stroke. Stroke 2009, 40:2704-2708. 10.1161/STROKEAHA.109.550228, 19542056.
20. Zhao D, Wang W, Liu J, Cheng J, Liu J, Qin LP. Association between body mass index and ten-year-accumulative-risk of hypertension. Zhonghua Liu Xing Bing Xue Za Zhi 2009, 30:435-438.
21. Lim JS, Kwon HM. Risk of silent stroke in patients older than 60 years: risk assessment and clinical perspectives. Clin Interv Aging 2010, 5:239-251. 2938031, 20852671.
22. Reiner AP, Siscovick DS, Rosendaal FR. Hemostatic risk factors and arterial thrombotic disease. Thromb Haemost 2001, 85:584-595.
23. Cushman M, Yanez D, Psaty BM, Fried LP, Heiss G, Lee M, Polak JF, Savage PJ, Tracy RP. Association of fibrinogen and coagulation factors VII and VIII with cardiovascular risk factors in the elderly: the cardiovascular health study. Cardiovascular health study investigators. Am J Epidemiol 1996, 143:665-676. 10.1093/oxfordjournals.aje.a008799, 8651228.
24. Cuisset T, Frere C, Quilici J, Morange PE, Camoin L, Bali L, Lambert M, Juhan-Vague I, Alessi MC, Bonnet JL. Relationship between aspirin and clopidogrel responses in acute coronary syndrome and clinical predictors of non response. Thromb Res 2009, 123:597-603. 10.1016/j.thromres.2008.04.003, 18499233.
25. Sibbing D, von Beckerath O, Schomig A, Kastrati A, von Beckerath N. Impact of body mass index on platelet aggregation after administration of a high loading dose of 600 mg of clopidogrel before percutaneous coronary intervention. Am J Cardiol 2007, 100:203-205. 10.1016/j.amjcard.2007.02.081, 17631070.