Stress Mediators and Immune Dysfunction in Patients with Acute Cerebrovascular Diseases

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Liesz, Arthur ^a   Rüger, Holger ^a   Purrucker, Jan ^a   Zorn, Markus ^a   Dalpke, Alexander ^a   Möhlenbruch, Markus ^a   Englert, Stefan ^a   Nawroth, Peter P ^a   Veltkamp, Roland ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CORTICOTROPIN; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 1BETA; METADRENALIN; NORADRENALIN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BACTERIAL INFECTION; BACTERIUM CULTURE; BRAIN DAMAGE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CELL SUBPOPULATION; CELLULAR IMMUNITY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FEMALE; HOSPITAL ADMISSION; HUMAN; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; INFECTION COMPLICATION; LEUKOCYTE; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OBSERVATIONAL STUDY; PREDICTIVE VALUE; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; STRESS; TRANSIENT ISCHEMIC ATTACK;

ADRENAL CORTEX HORMONES; AGED; BACTERIAL INFECTIONS; BIOLOGICAL MARKERS; CEREBRAL HEMORRHAGE; CEREBROVASCULAR DISORDERS; FEMALE; HUMANS; IMMUNOMODULATION; ISCHEMIA; LYMPHOPENIA; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; ROC CURVE;

EID: 84884373309     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074839     Document Type: Article

References (34)

1. Davenport RJ, Dennis MS, Wellwood I, Warlow CP, (1996) Complications after acute stroke. Stroke 27: 415-420.
2. Westendorp WF, Nederkoorn PJ, Vermeij JD, Dijkgraaf MG, van de Beek D (2011) Post-stroke infection: A systematic review and meta-analysis. BMC neurology 11.
3. Katzan IL, Cebul RD, Husak SH, Dawson NV, Baker DW, (2003) The effect of pneumonia on mortality among patients hospitalized for acute stroke. Neurology 60: 620-625.
4. Sellars C, Bowie L, Bagg J, Sweeney MP, Miller H, et al. (2007) Risk factors for chest infection in acute stroke: a prospective cohort study. Stroke 38: 2284-2291.
5. Emsley HCa, Smith CJ, Gavin CM, Georgiou RF, Vail A, et al. (2007) Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC neurology 7: 5-5.
6. Urra X, Cervera A, Obach V, Climent N, Planas AM, et al. (2009) Monocytes are major players in the prognosis and risk of infection after acute stroke. Stroke 40: 1262-1268.
7. Chamorro A, Urra X, Planas AM, (2007) Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression. Stroke 38: 1097-1103.
8. Prass K, Meisel C, Hoflich C, Braun J, Halle E, et al. (2003) Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 198: 725-736.
9. Urra X, Obach V, Chamorro A, (2009) Stroke induced immunodepression syndrome: from bench to bedside. Curr Mol Med 9: 195-202.
10. Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, et al. (2007) Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke 38: 770-773.
11. Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U, (2005) Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci 6: 775-786.
12. Hug A, Dalpke A, Wieczorek N, Giese T, Lorenz A, et al. (2009) Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection. Stroke 40: 3226-3232.
13. Liesz A, Hagmann S, Zschoche C, Adamek J, Zhou W, et al. (2009) The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation. Stroke 40: 2849-2858.
14. Chamorro A, Amaro S, Vargas M, Obach V, Cervera A, et al. (2007) Catecholamines, infection, and death in acute ischemic stroke. J Neurol Sci 252: 29-35.
15. Klehmet J, Harms H, Richter M, Prass K, Volk HD, et al. (2009) Stroke-induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial. Neuroscience 158: 1184-1193.
16. Chamorro A, Meisel A, Planas AM, Urra X, van de Beek D, et al. (2012) The immunology of acute stroke. Nature reviews Neurology 8: 401-410.
17. Illanes S, Liesz A, Sun L, Dalpke A, Zorn M, et al. (2011) Hematoma size as major modulator of the cellular immune system after experimental intracerebral hemorrhage. Neurosci Lett 490: 170-174.
18. Adams HP Jr, (1993) Trials of trials in acute ischemic stroke. The Humana Lecture. Stroke 24: 1410-1415.
19. Smith CJ, Emsley HC, Gavin CM, Georgiou RF, Vail A, et al. (2004) Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol 4: 2-2.
20. Cruse JM, Lewis RE, Bishop GR, Kliesch WF, Gaitan E, (1992) Neuroendocrine-immune interactions associated with loss and restoration of immune system function in spinal cord injury and stroke patients. Immunol Res 11: 104-116.
21. Harms H, Reimnitz P, Bohner G, Werich T, Klingebiel R, et al. (2011) Influence of stroke localization on autonomic activation, immunodepression, and post-stroke infection. Cerebrovasc Dis 32: 552-560.
22. Ajmo CT Jr, Collier LA, Leonardo CC, Hall AA, Green SM, et al. (2009) Blockade of adrenoreceptors inhibits the splenic response to stroke. Exp Neurol 218: 47-55.
23. Tarkowski E, Naver H, Wallin BG, Blomstrand C, Tarkowski A, (1995) Lateralization of T-lymphocyte responses in patients with stroke. Effect of sympathetic dysfunction? Stroke 26: 57-62.
24. Emsley HC, Smith CJ, Gavin CM, Georgiou RF, Vail A, et al. (2003) An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J Neuroimmunol 139: 93-101.
25. Haeusler KG, Schmidt WU, Fohring F, Meisel C, Helms T, et al. (2008) Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovasc Dis 25: 50-58.
26. Smith CJ, Emsley HC, Vail A, Georgiou RF, Rothwell NJ, et al. (2006) Variability of the systemic acute phase response after ischemic stroke. J Neurol Sci 251: 77-81.
27. Walter U, Kolbaske S, Patejdl R, Steinhagen V, Abu-Mugheisib M, et al. (2013) Insular stroke is associated with acute sympathetic hyperactivation and immunodepression. Eur J Neurol 20: 153-159.
28. Urra X, Cervera A, Villamor N, Planas AM, Chamorro A, (2009) Harms and benefits of lymphocyte subpopulations in patients with acute stroke. Neuroscience 158: 1174-1183.
29. Vogelgesang A, Grunwald U, Langner S, Jack R, Broker BM, et al. (2008) Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke. Stroke 39: 237-241.
30. Emsley HC, Hopkins SJ, (2008) Acute ischaemic stroke and infection: recent and emerging concepts. Lancet Neurol 7: 341-353.
31. Brait VH, Arumugam TV, Drummond GR, Sobey CG, (2012) Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. J Cereb Blood Flow Metab 32: 598-611.
32. Diamond B, Tracey KJ, (2011) Mapping the immunological homunculus. Proc Natl Acad Sci U S A 108: 3461-3462.
33. Hug A, Murle B, Dalpke A, Zorn M, Liesz A, et al. (2010) Usefulness of Serum Procalcitonin Levels for the Early Diagnosis of Stroke-Associated Respiratory Tract Infections. Neurocrit Care.
34. Gumbinger C, Hug A, Murle B, Berger B, Zorn M, et al. (2012) Early blood-based microbiological testing is ineffective in severe stroke patients. J Neurol Sci.