An integrative model of the cardiovascular system coupling heart cellular mechanics with arterial network hemodynamics

Journal of Korean Medical Science

Volumn 28, Issue 8, 2013, Pages 1161-1168

  Kim, Young Tae ^a   Lee, Jeong Sang ^a,b   Youn, Chan Hyun ^c   Choi, Jae Sung ^b   Shim, Eun Bo ^a  

^a Kangwon National University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Blood pressure; Computer simulation; Hypertrophy; Integrative cell system arterial network model; Left ventricular

Indexed keywords

AORTA; ARTERY; ARTICLE; BIOLOGICAL MODEL; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; COMPUTER SIMULATION; HEART LEFT VENTRICLE HYPERTROPHY; HEART VENTRICLE FUNCTION; HEMODYNAMICS; HUMAN; INTEGRATIVE CELL-SYSTEM-ARTERIAL NETWORK MODEL; PATHOPHYSIOLOGY; PHYSIOLOGY;

BLOOD PRESSURE; COMPUTER SIMULATION; HYPERTROPHY, LEFT VENTRICULAR; INTEGRATIVE CELL-SYSTEM-ARTERIAL NETWORK MODEL;

AORTA; ARTERIES; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; COMPUTER SIMULATION; HEMODYNAMICS; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MODELS, BIOLOGICAL; VENTRICULAR FUNCTION;

EID: 84884359819     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2013.28.8.1161     Document Type: Article

References (31)

1. Abhayaratna WP, Barnes ME, O'Rourke MF, Gersh BJ, Seward JB, Miyasaka Y, Bailey KR, Tsang TS. Relation of arterial stiffness to left ventricular diastolic function and cardiovascular risk prediction in patients > or =65 years of age. Am J Cardiol 2006; 98: 1387-92.
2. Urbina EM, Dolan LM, McCoy CE, Khoury PR, Daniels SR, Kimball TR. Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults. J Pediatr 2011; 158: 715-21.
3. Kerckhoffs RC, Neal ML, Gu Q, Bassingthwaighte JB, Omens JH, Mc-Culloch AD. Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation. Ann Biomed Eng 2007; 35: 1-18.
4. Lim KM, Lee JS, Song JH, Youn CH, Choi JS, Shim EB. Theoretical estimation of cannulation methods for left ventricular assist device support as a bridge to recovery. J Korean Med Sci 2011; 26: 1591-8.
5. Trayanova NA, Rice JJ. Cardiac electromechanical models: from cell to organ. Front Physiol 2011; 2: 43.
6. Campbell SG, McCulloch AD. Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype. J R Soc Interface 2011; 8: 1550-61.
7. Shim EB, Sah JY, Youn CH. Mathematical modeling of cardiovascular system dynamics using a lumped parameter method. Jpn J Physiol 2004; 54: 545-53.
8. Shim EB, Leem CH, Abe Y, Noma A. A new multi-scale simulation model of the circulation: from cells to system. Philos Trans A Math Phys Eng Sci 2006; 364: 1483-500.
9. Shim EB, Amano A, Takahata T, Shimayoshi T, Noma A. The crossbridge dynamics during ventricular contraction predicted by coupling the cardiac cell model with a circulation model. J Physiol Sci 2007; 57: 275-85.
10. Shim EB, Jun HM, Leem CH, Matusuoka S, Noma A. A new integrated method for analyzing heart mechanics using a cell-hemodynamics-autonomic nerve control coupled model of the cardiovascular system. Prog Biophys Mol Biol 2008; 96: 44-59.
11. Ozawa ET, Bottom KE, Xiao X, Kamm RD. Numerical simulation of enhanced external counterpulsation. Ann Biomed Eng 2001; 29: 284-97.
12. Stettler JC, Niederer P, Anliker M. Theoretical analysis of arterial hemodynamics including the influence of bifurcations: part I: mathematical models and prediction of normal pulse patterns. Ann Biomed Eng 1981; 9: 145-64.
13. Avolio AP. Multi-branched model of the human arterial system. Med Biol Eng Comput 1980; 18: 709-18.
14. Dell'Italia LJ, Walsh RA. Application of a time varying elastance model to right ventricular performance in man. Cardiovasc Res 1988; 22: 864-74.
15. Negroni JA, Lascano EC. A cardiac muscle model relating sarcomere dynamics to calcium kinetics. J Mol Cell Cardiol 1996; 28: 915-29.
16. Nygren A, Fiset C, Firek L, Clark JW, Lindblad DS, Clark RB, Giles WR. Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization. Circ Res 1998; 82: 63-81.
17. ten Tusscher KH, Noble D, Noble PJ, Panfilov AV. A model for human ventricular tissue. Am J Physiol Heart Circ Physiol 2004; 286: H1573-89.
18. Matsuoka S, Sarai N, Kuratomi S, Ono K, Noma A. Role of individual ionic current systems in ventricular cells hypothesized by a model study. Jpn J Physiol 2003; 53: 105-23.
19. Heldt T, Shim EB, Kamm RD, Mark RG. Computational modeling of cardiovascular response to orthostatic stress. J Appl Physiol 2002; 92: 1239-54.
20. Avolio AP. Multi-branched model of the human arterial system. Med Biol Eng Comput 1980; 18: 709-18.
21. Izzo JL Jr, Shykoff BE. Arterial stiffness: clinical relevance, measurement, and treatment. Rev Cardiovasc Med 2001; 2: 29-34.
22. Gozna ER, Marble AE, Shaw AJ, Winter DA. Mechanical properties of the ascending thoracic aorta of man. Cardiovasc Res1973; 7: 261-5.
23. Lehmann ED, Parker JR, Hopkins KD, Taylor MG, Gosling RG. Validation and reproducibility of pressure-corrected aortic distensibility measurements using pulse-wave-velocity Doppler ultrasound. J Biomed Eng 1993; 15: 221-8.
24. Stewart AD, Millasseau SC, Kearney MT, Ritter JM, Chowienczyk PJ. Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans. Hypertension 2003; 42: 915-8.
25. Roman MJ, Devereux RB, Kizer JR, Okin PM, Lee ET, Wang W, Umans JG, Calhoun D, Howard BV. High central pulse pressure is independently associated with adverse cardiovascular outcome the strong heart study. J Am Coll Cardiol 2009; 54: 1730-4.
26. Wang KL, Cheng HM, Chuang SY, Spurgeon HA, Ting CT, Lakatta EG, Yin FC, Chou P, Chen CH. Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality? J Hypertens 2009; 27: 461-7.
27. Rochette L, Tatou E, Maupoil V, Zeller M, Cottin Y, Jazayeri S, Brenot R, Girard C, David M, Vergely C. Atrial and vascular oxidative stress in patients with heart failure. Cell Physiol Biochem 2011; 27: 497-502.
28. Kashif FM, Verghese GC, Novak V, Czosnyka M, Heldt T. Model-based noninvasive estimation of intracranial pressure from cerebral blood flow velocity and arterial pressure. Sci Transl Med 2012; 4: 129ra44.
29. Landesberg A, Sideman S. Mechanical regulation of cardiac muscle by coupling calcium kinetics with cross-bridge cycling: a dynamic model. Am J Physiol 1994; 267: H779-95.
30. Beyar R, Sideman S. Atrioventricular interactions: a theoretical simulation study. Am J Physiol 1987; 252: H653-65.
31. Ursino M, Innocenti M. Modeling arterial hypotension during hemodialysis. Artif Organs 1997; 21: 873-90.