TYMS serves as a prognostic indicator to predict the lymph node metastasis in Chinese patients with colorectal cancer

Clinical Biochemistry

Volumn 46, Issue 15, 2013, Pages 1478-1483

  Lu, Yuanfang ^a   Zhuo, Changhua ^b,d   Cui, Bota ^a   Liu, Zhengxia ^a   Zhou, Ping ^a   Lu, Yuanming ^c,d   Wang, Baolin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^d FUDAN UNIVERSITY   (China)

Author keywords

Colorectal cancer; DNA repair; Lymph node metastasis; Prognosis; Quantitative real time PCR analysis; TYMS

Indexed keywords

BIOLOGICAL MARKER; THYMIDYLATE SYNTHASE;

ADULT; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CHINESE; COLORECTAL CARCINOMA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECURRENCE RISK;

COLORECTAL CANCER; DNA REPAIR; LYMPH NODE METASTASIS; PROGNOSIS; QUANTITATIVE REAL-TIME PCR ANALYSIS; TYMS;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; SURVIVAL ANALYSIS; THYMIDYLATE SYNTHASE; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84884350282     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2013.06.017     Document Type: Article

References (27)

1. Fidler I.J. Cancer metastasis. Br Med Bull 1991, 47:157-177.
2. Strimpakos A.S., Cunningham D., Mikropoulos C., Petkar I., Barbachano Y., Chau I. The impact of carcinoembryonic antigen flare in patients with advanced colorectal cancer receiving first-line chemotherapy. Ann Oncol 2010, 21:1013-1019.
3. O'Connell J.B., Maggard M.A., Ko C.Y. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 2004, 96:1420-1425.
4. Royston D., Jackson D.G. Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma. J Pathol 2009, 217:608-619.
5. Sundar S.S., Ganesan T.S. Role of lymphangiogenesis in cancer. J Clin Oncol 2007, 25:4298-4307.
6. Ricciardi R., Madoff R.D., Rothenberger D.A., Baxter N.N. Population-based analyses of lymph node metastases in colorectal cancer. Clin Gastroenterol Hepatol 2006, 4:1522-1527.
7. Fang W., Fan B., Xiong B. Analysis of pathological risk factors for lymph node metastasis in colorectal cancer. Hepatogastroenterology 2009, 56:663-666.
8. AJCC Cancer staging handbook seventh edition [Access nov. 2010]. http://www.cancerstaging.org/staging/index.html.
9. Schiffer C.A., Clifton I.J., Davisson V.J., Santi D.V., Stroud R.M. Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry 1995, 34:16279-16287.
10. Dong S., Lester L., Johnson L.F. Transcriptional control elements and complex initiation pattern of the TATA-less bidirectional human thymidylate synthase promoter. J Cell Biochem 2000, 77:50-64.
11. Pestalozzi B.C., Peterson H.F., Gelber R.D., Goldhirsch A., Gusterson B.A., Trihia H., et al. Prognostic importance of thymidylate synthase expression in early breast cancer. J Clin Oncol 1997, 15:1923-1931.
12. Nomura T., Nakagawa M., Fujita Y., Hanada T., Mimata H., Nomura Y. Clinical significance of thymidylate synthase expression in bladder cancer. Int J Urol 2002, 9:368-376.
13. Suzuki M., Tsukagoshi S., Saga Y., Ohwada M., Sato I. Enhanced expression of thymidylate synthase may be of prognostic importance in advanced cervical cancer. Oncology 1999, 57:50-54.
14. Mizutani Y., Wada H., Yoshida O., Fukushima M., Nonomura M., Nakao M., et al. Significance of thymidylate synthase activity in renal cell carcinoma. Clin Cancer Res 2003, 9:1453-1460.
15. Shintani Y., Ohta M., Hirabayashi H., Tanaka H., Iuchi K., Nakagawa K., et al. New prognostic indicator for non-small-cell lung cancer, quantitation of thymidylate synthase by real-time reverse transcription polymerase chain reaction. Int J Cancer 2003, 104:790-795.
16. Leichman C.G. Predictive and prognostic markers in gastrointestinal cancers. Curr Opin Oncol 2001, 13:291-299.
17. Rahman L., Voeller D., Rahman M., Lipkowitz S., Allegra C., Barrett J.C., et al. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell 2004, 5:341-351.
18. Chen M., Rahman L., Voeller D., Kastanos E., Yang S.X., Feigenbaum L., et al. Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas. Oncogene 2007, 26:4817-4824.
19. Goto T., Shinmura K., Yokomizo K., Sakuraba K., Kitamura Y., Shirahata A., et al. Expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase in patients with colorectal cancer. Anticancer Res May 2012, 32(5):1757-1762.
20. Pander J., Wessels J.A., Gelderblom H., van der Straaten T., Punt C.J., Guchelaar H.J. Pharmacogenetic interaction analysis for the efficacy of systemic treatment in metastatic colorectal cancer. Ann Oncol May 2011, 22(5):1147-1153.
21. Yoshida T., Kobayashi T., Itoda M., Muto T., Miyaguchi K., Mogushi K., et al. Clinical omics analysis of colorectal cancer incorporating copy number aberrations and gene expression data. Cancer Inf Jul 29 2010, 9:147-161.
22. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
23. Werner A., Bendre E., Mahanffey W. Inhibition of experimental liver metastasis by combined treatment with tamoxifen and interferon. Anticancer Drugs 1996, 7(3):307.
24. Ulrich C.M., Bigler J., Bostick R. Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res 2002, 62:3361-3364.
25. Hishida A., Matsuo K., Hamajima N. Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma. Haematologica 2003, 88:159-166.
26. Skibola C.F., Smith M.T., Hubbard A. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood 2002, 99:3786-3791.
27. Ishida Y., Kawakami K., Tanaka Y. Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer. Anticancer Res 2002, 22:2805-2809.