-
2
-
-
80053484515
-
Integrating predictive biomarkers and classifiers into oncology clinical development programmes
-
Beckman RA, Clark J, Chen C. Integrating predictive biomarkers and classifiers into oncology clinical development programmes. Nat Rev Drug Discov 2011;10: 735-48.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 735-748
-
-
Beckman, R.A.1
Clark, J.2
Chen, C.3
-
3
-
-
77956898655
-
The immune response and the therapeutic effect of metronomic chemotherapy with cyclophosphamide
-
Rozados VR, Mainetti LE, Rico MJ, Zacarias Fluck MF, Matar P, Scharovsky OG. The immune response and the therapeutic effect of metronomic chemotherapy with cyclophosphamide. Oncol Res 2010;18: 601-5.
-
(2010)
Oncol Res
, vol.18
, pp. 601-605
-
-
Rozados, V.R.1
Mainetti, L.E.2
Rico, M.J.3
Zacarias Fluck, M.F.4
Matar, P.5
Scharovsky, O.G.6
-
4
-
-
6944241246
-
Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity
-
Rozados VR, Sanchez AM, Gervasoni SI, Berra HH, Matar P, Graciela Scharovsky O. Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity. Ann Oncol 2004;15: 1543-50.
-
(2004)
Ann Oncol
, vol.15
, pp. 1543-1550
-
-
Rozados, V.R.1
Sanchez, A.M.2
Gervasoni, S.I.3
Berra, H.H.4
Matar, P.5
Graciela Scharovsky, O.6
-
5
-
-
78751630984
-
Antitumoral and antimetastatic effects of metronomic chemotherapy with cyclophosphamide combined with celecoxib on murine mammary adenocarcinomas
-
Mainetti LE, Rozados VR, Rossa A, Bonfil RD, Scharovsky OG. Antitumoral and antimetastatic effects of metronomic chemotherapy with cyclophosphamide combined with celecoxib on murine mammary adenocarcinomas. J Cancer Res Clin Oncol 2011;137: 151-63.
-
(2011)
J Cancer Res Clin Oncol
, vol.137
, pp. 151-163
-
-
Mainetti, L.E.1
Rozados, V.R.2
Rossa, A.3
Bonfil, R.D.4
Scharovsky, O.G.5
-
6
-
-
84861234300
-
Pilot study of a pediatric metronomic 4-drug regimen
-
Andre N, Abed S, Orbach D, Alla CA, Padovani L, Pasquier E, et al. Pilot study of a pediatric metronomic 4-drug regimen. Oncotarget 2011;2: 960-5.
-
(2011)
Oncotarget
, vol.2
, pp. 960-965
-
-
Andre, N.1
Abed, S.2
Orbach, D.3
Alla, C.A.4
Padovani, L.5
Pasquier, E.6
-
7
-
-
84874856960
-
Safety and therapeutic effect of metronomic chemotherapy with cyclophosphamide and celecoxib in advanced breast cancer patients
-
Perroud H, Rico M, Alasino C, Queralt F, Pezzotto S, Rozados V, Scharovsky O. Safety and therapeutic effect of metronomic chemotherapy with cyclophosphamide and celecoxib in advanced breast cancer patients. Future Oncol 2013;9: 451-62.
-
(2013)
Future Oncol
, vol.9
, pp. 451-462
-
-
Perroud, H.1
Rico, M.2
Alasino, C.3
Queralt, F.4
Pezzotto, S.5
Rozados, V.6
Scharovsky, O.7
-
8
-
-
79960616984
-
Pegylated liposomal doxorubicin in combination with low-dose metronomic cyclophosphamide as preoperative treatment for patients with locally advanced breast cancer
-
Dellapasqua S, Mazza M, Rosa D, Ghisini R, Scarano E, Torrisi R, et al. Pegylated liposomal doxorubicin in combination with low-dose metronomic cyclophosphamide as preoperative treatment for patients with locally advanced breast cancer. Breast 2011;20: 319-23.
-
(2011)
Breast
, vol.20
, pp. 319-323
-
-
Dellapasqua, S.1
Mazza, M.2
Rosa, D.3
Ghisini, R.4
Scarano, E.5
Torrisi, R.6
-
9
-
-
0034048358
-
Less is more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
-
Hanahan D, Bergers G, Bergsland E. Less is more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest 2000;105: 1045-7.
-
(2000)
J Clin Invest
, vol.105
, pp. 1045-1047
-
-
Hanahan, D.1
Bergers, G.2
Bergsland, E.3
-
10
-
-
84873628875
-
Antitumor effect of metformin in esophageal cancer: In vitro study
-
Kobayashi M, Kato K, Iwama H, Fujihara S, Nishiyama N, Mimura S, et al. Antitumor effect of metformin in esophageal cancer: In vitro study. Int J Oncol 2013;42: 517-24.
-
(2013)
Int J Oncol
, vol.42
, pp. 517-524
-
-
Kobayashi, M.1
Kato, K.2
Iwama, H.3
Fujihara, S.4
Nishiyama, N.5
Mimura, S.6
-
11
-
-
84866538325
-
Metformin in early breast cancer: A prospective window of opportunity neoadjuvant study
-
Niraula S, Dowling RJ, Ennis M, Chang MC, Done SJ, Hood N, et al. Metformin in early breast cancer: A prospective window of opportunity neoadjuvant study. Breast Cancer Res Treat 2012;135: 821-30.
-
(2012)
Breast Cancer Res Treat
, vol.135
, pp. 821-830
-
-
Niraula, S.1
Dowling, R.J.2
Ennis, M.3
Chang, M.C.4
Done, S.J.5
Hood, N.6
-
12
-
-
84858428443
-
Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: Implication in breast cancer treatment
-
Pasquier E, Ciccolini J, Carre M, Giacometti S, Fanciullino R, Pouchy C, et al. Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: Implication in breast cancer treatment. Oncotarget 2011;2: 797-809.
-
(2011)
Oncotarget
, vol.2
, pp. 797-809
-
-
Pasquier, E.1
Ciccolini, J.2
Carre, M.3
Giacometti, S.4
Fanciullino, R.5
Pouchy, C.6
-
13
-
-
84871155102
-
Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in vitro and in vivo
-
Dai ZJ, Ma XB, Kang HF, Gao J, Min WL, Guan HT, et al. Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in vitro and in vivo. Cancer Cell Int 2012;12:53.
-
(2012)
Cancer Cell Int
, vol.12
, pp. 53
-
-
Dai, Z.J.1
Ma, X.B.2
Kang, H.F.3
Gao, J.4
Min, W.L.5
Guan, H.T.6
-
14
-
-
30744479430
-
Angiogenesis in life, disease and medicine
-
Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005;438: 932-6.
-
(2005)
Nature
, vol.438
, pp. 932-936
-
-
Carmeliet, P.1
-
15
-
-
2942615257
-
The anti-angiogenic basis of metronomic chemotherapy
-
Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4: 423-36.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 423-436
-
-
Kerbel, R.S.1
Kamen, B.A.2
-
16
-
-
49649090640
-
Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance? World journal of Gastroenterology
-
Tsirlis TD, Papastratis G, Masselou K, Tsigris C, Papachristodoulou A, Kostakis A, et al. Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance? World journal of Gastroenterology. World J Gastroenterol 2008;14: 2691-701.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 2691-2701
-
-
Tsirlis, T.D.1
Papastratis, G.2
Masselou, K.3
Tsigris, C.4
Papachristodoulou, A.5
Kostakis, A.6
-
17
-
-
84856203237
-
Expression and clinical significance of extracellular matrix protein 1 and vascular endothelial growth factor-C in lymphatic metastasis of human breast cancer
-
Wu QW, She HQ, Liang J, Huang YF, Yang QM, Yang QL, et al. Expression and clinical significance of extracellular matrix protein 1 and vascular endothelial growth factor-C in lymphatic metastasis of human breast cancer. BMC Cancer 2012;12:47.
-
(2012)
BMC Cancer
, vol.12
, pp. 47
-
-
Wu, Q.W.1
She, H.Q.2
Liang, J.3
Huang, Y.F.4
Yang, Q.M.5
Yang, Q.L.6
-
18
-
-
69949160832
-
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth
-
Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, et al. Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med 2009;15: 1023-30.
-
(2009)
Nat Med
, vol.15
, pp. 1023-1030
-
-
Albuquerque, R.J.1
Hayashi, T.2
Cho, W.G.3
Kleinman, M.E.4
Dridi, S.5
Takeda, A.6
-
19
-
-
39049165334
-
Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth
-
Ebos JM, Lee CR, Bogdanovic E, Alami J, Van Slyke P, Francia G, et al. Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth. Cancer Res 2008;68: 521-9.
-
(2008)
Cancer Res
, vol.68
, pp. 521-529
-
-
Ebos, J.M.1
Lee, C.R.2
Bogdanovic, E.3
Alami, J.4
Van Slyke, P.5
Francia, G.6
-
20
-
-
33746621996
-
Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
-
Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, et al. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A 2006;103: 11405-10.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11405-11410
-
-
Cursiefen, C.1
Chen, L.2
Saint-Geniez, M.3
Hamrah, P.4
Jin, Y.5
Rashid, S.6
-
21
-
-
79953790937
-
Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer
-
Yang H, Kim C, Kim MJ, Schwendener RA, Alitalo K, Heston W, et al. Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Mol Cancer 2011;10:36.
-
(2011)
Mol Cancer
, vol.10
, pp. 36
-
-
Yang, H.1
Kim, C.2
Kim, M.J.3
Schwendener, R.A.4
Alitalo, K.5
Heston, W.6
-
22
-
-
33847198622
-
The role of the VEGF-C/VEGFR-3 axis in cancer progression
-
Su JL, Yen CJ, Chen PS, Chuang SE, Hong CC, Kuo IH, et al. The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer 2007;96: 541-5.
-
(2007)
Br J Cancer
, vol.96
, pp. 541-545
-
-
Su, J.L.1
Yen, C.J.2
Chen, P.S.3
Chuang, S.E.4
Hong, C.C.5
Kuo, I.H.6
-
23
-
-
79958008007
-
Targeting tumor angiogenesis with TSP-1-based compounds: Rational design of antiangiogenic mimetics of endogenous inhibitors
-
Taraboletti G, Rusnati M, Ragona L, Colombo G. Targeting tumor angiogenesis with TSP-1-based compounds: Rational design of antiangiogenic mimetics of endogenous inhibitors. Oncotarget 2010;1: 662-73.
-
(2010)
Oncotarget
, vol.1
, pp. 662-673
-
-
Taraboletti, G.1
Rusnati, M.2
Ragona, L.3
Colombo, G.4
-
24
-
-
0242331613
-
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
-
Bocci G, Francia G, Man S, Lawler J, Kerbel RS. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A 2003;100: 12917-22.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12917-12922
-
-
Bocci, G.1
Francia, G.2
Man, S.3
Lawler, J.4
Kerbel, R.S.5
-
25
-
-
77649221837
-
Phase I/II trial of metronomic chemotherapy with daily dalteparin and cyclophosphamide, twice-weekly methotrexate, and daily prednisone as therapy for metastatic breast cancer using vascular endothelial growth factor and soluble vascular endothelial growth factor receptor levels as markers of response
-
Wong NS, Buckman RA, Clemons M, Verma S, Dent S, Trudeau ME, et al. Phase I/II trial of metronomic chemotherapy with daily dalteparin and cyclophosphamide, twice-weekly methotrexate, and daily prednisone as therapy for metastatic breast cancer using vascular endothelial growth factor and soluble vascular endothelial growth factor receptor levels as markers of response. J Clin Oncol 2010;28: 723-30.
-
(2010)
J Clin Oncol
, vol.28
, pp. 723-730
-
-
Wong, N.S.1
Buckman, R.A.2
Clemons, M.3
Verma, S.4
Dent, S.5
Trudeau, M.E.6
-
26
-
-
42549167589
-
Circulating biomarkers of bevacizumab activity in patients with breast cancer
-
Denduluri N, Yang SX, Berman AW, Nguyen D, Liewehr DJ, Steinberg SM, et al. Circulating biomarkers of bevacizumab activity in patients with breast cancer. Cancer Biol Ther 2008;7: 15-20.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 15-20
-
-
Denduluri, N.1
Yang, S.X.2
Berman, A.W.3
Nguyen, D.4
Liewehr, D.J.5
Steinberg, S.M.6
-
27
-
-
84864945437
-
Soluble KIT correlates with clinical outcome in patients with metastatic breast cancer treated with sunitinib
-
Keyvanjah K, DePrimo SE, Harmon CS, Huang X, Kern KA, Carley W. Soluble KIT correlates with clinical outcome in patients with metastatic breast cancer treated with sunitinib. J Transl Med 2012;10:165.
-
(2012)
J Transl Med
, vol.10
, pp. 165
-
-
Keyvanjah, K.1
Deprimo, S.E.2
Harmon, C.S.3
Huang, X.4
Kern, K.A.5
Carley, W.6
-
28
-
-
34547779489
-
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: Modulation of VEGF and VEGF-related proteins
-
Deprimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, et al. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: Modulation of VEGF and VEGF-related proteins. J Transl Med 2007;5:32.
-
(2007)
J Transl Med
, vol.5
, pp. 32
-
-
Deprimo, S.E.1
Bello, C.L.2
Smeraglia, J.3
Baum, C.M.4
Spinella, D.5
Rini, B.I.6
-
29
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
-
Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 2008;26: 3743-8.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
Bukowski, R.M.4
Sosman, J.A.5
Stadler, W.M.6
-
30
-
-
77955512358
-
Lymphangiogenesis and lymphatic metastasis in breast cancer
-
Ran S, Volk L, Hall K, Flister MJ. Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology 2010;17: 229-51.
-
(2010)
Pathophysiology
, vol.17
, pp. 229-251
-
-
Ran, S.1
Volk, L.2
Hall, K.3
Flister, M.J.4
-
31
-
-
80053173900
-
Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving "metronomic" zoledronic acid
-
Zhao X, Xu X, Zhang Q, Jia Z, Sun S, Zhang J, et al. Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving "metronomic" zoledronic acid. BMC Cancer 2011;11:403.
-
(2011)
BMC Cancer
, vol.11
, pp. 403
-
-
Zhao, X.1
Xu, X.2
Zhang, Q.3
Jia, Z.4
Sun, S.5
Zhang, J.6
-
32
-
-
78751633481
-
Circulating levels of angiogenic cytokines in advanced breast cancer patients with system chemotherapy and their potential value in monitoring disease course
-
Tang JH, Zhao JH, Lu JW, Yan F, Qin JW, Xu B. Circulating levels of angiogenic cytokines in advanced breast cancer patients with system chemotherapy and their potential value in monitoring disease course. J Cancer Res Clin Oncol 2011;137: 55-63.
-
(2011)
J Cancer Res Clin Oncol
, vol.137
, pp. 55-63
-
-
Tang, J.H.1
Zhao, J.H.2
Lu, J.W.3
Yan, F.4
Qin, J.W.5
Xu, B.6
-
33
-
-
68049137904
-
Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer
-
Fontana A, Galli L, Fioravanti A, Orlandi P, Galli C, Landi L, et al. Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer. Clin Cancer Res 2009;15: 4954-62.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4954-4962
-
-
Fontana, A.1
Galli, L.2
Fioravanti, A.3
Orlandi, P.4
Galli, C.5
Landi, L.6
-
34
-
-
84866275588
-
Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab
-
Madsen CV, Steffensen KD, Olsen DA, Waldstrom M, Smerdel M, Adimi P, et al. Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab. J Ovarian Res 2012;5:23.
-
(2012)
J Ovarian Res
, vol.5
, pp. 23
-
-
Madsen, C.V.1
Steffensen, K.D.2
Olsen, D.A.3
Waldstrom, M.4
Smerdel, M.5
Adimi, P.6
-
35
-
-
84863897798
-
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial
-
Van Cutsem E, de Haas S, Kang YK, Ohtsu A, Tebbutt NC, Ming Xu J, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial. J Clin Oncol 2012;30: 2119-27.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2119-2127
-
-
Van Cutsem, E.1
De Haas, S.2
Kang, Y.K.3
Ohtsu, A.4
Tebbutt, N.C.5
Ming Xu, J.6
-
36
-
-
84859880607
-
Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma
-
Llovet JM, Pena CE, Lathia CD, Shan M, Meinhardt G, Bruix J. Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2012;18: 2290-300.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2290-2300
-
-
Llovet, J.M.1
Pena, C.E.2
Lathia, C.D.3
Shan, M.4
Meinhardt, G.5
Bruix, J.6
-
37
-
-
84862778690
-
Analysis of circulating angiogenic biomarkers from patients in two phase III trials in lung cancer of chemotherapy alone or chemotherapy and thalidomide
-
Young RJ, Tin AW, Brown NJ, Jitlal M, Lee SM, Woll PJ. Analysis of circulating angiogenic biomarkers from patients in two phase III trials in lung cancer of chemotherapy alone or chemotherapy and thalidomide. Br J Cancer 2012;106: 1153-9.
-
(2012)
Br J Cancer
, vol.106
, pp. 1153-1159
-
-
Young, R.J.1
Tin, A.W.2
Brown, N.J.3
Jitlal, M.4
Lee, S.M.5
Woll, P.J.6
-
38
-
-
79953183344
-
Levels of circulating CD45(dim) CD34(+) VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors
-
Farace F, Gross-Goupil M, Tournay E, Taylor M, Vimond N, Jacques N, et al. Levels of circulating CD45(dim) CD34(+) VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors. Br J Cancer 2011;104: 1144-50.
-
(2011)
Br J Cancer
, vol.104
, pp. 1144-1150
-
-
Farace, F.1
Gross-Goupil, M.2
Tournay, E.3
Taylor, M.4
Vimond, N.5
Jacques, N.6
|