Characterization of a methyltransferase involved in herboxidiene biosynthesis

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5667-5670

  Yu, Dayu ^a,b   Xu, Fuchao ^b   Zhang, Shuwei ^b   Shao, Lei ^b   Wang, Siyuan ^b   Zhan, Jixun ^b  

^a NORTHEAST ELECTRIC POWER UNIVERSITY   (China)

^b Utah State University   (United States)

Author keywords

Anti cholesterol; Herboxidiene; Methyltransferase; Polyketide biosynthesis; Tailoring reaction

Indexed keywords

18 DEOXY 25 DEMETHYL HERBOXIDIENE; 25 DEMETHYL HERBOXIDIENE; APRAMYCIN; GENOMIC DNA; METHYLTRANSFERASE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENOME; BACTERIAL STRAIN; BIOSYNTHESIS; ENZYME KINETICS; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE CLUSTER; GENE EXPRESSION; GENE INSERTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METHYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; STREPTOMYCES; STREPTOMYCES CHROMOFUSCUS; WILD TYPE;

ESCHERICHIA COLI; STREPTOMYCES CHROMOFUSCUS;

ANTI-CHOLESTEROL; HERBOXIDIENE; METHYLTRANSFERASE; POLYKETIDE BIOSYNTHESIS; TAILORING REACTION;

BACTERIAL PROTEINS; ESCHERICHIA COLI; FATTY ALCOHOLS; GENOME, BACTERIAL; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLTRANSFERASES; MOLECULAR CONFORMATION; MULTIGENE FAMILY; MUTATION; POLYKETIDE SYNTHASES; PYRANS; STREPTOMYCES;

EID: 84884290304     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.023     Document Type: Article

References (7)

1. B.G. Isaac, S.W. Ayer, R.C. Elliott, and R.J. Stonard J. Org. Chem. 57 1992 7220
2. L. Shao, J. Zi, J. Zeng, and J. Zhan Appl. Environ. Microbiol. 78 2012 2034
3. M.G. Reese Comput. Chem. 26 2001 51
4. W. Zhang, K. Watanabe, X. Cai, M.E. Jung, Y. Tang, and J. Zhan J. Am. Chem. Soc. 130 2008 6068
5. M.L. Dickens, J. Ye, and W.R. Strohl J. Bacteriol. 177 1995 536
6. D. Ingrosso, A.V. Fowler, J. Bleibaum, and S. Clarke J. Biol. Chem. 264 1989 20131
7. M. Varoglu, Y. Mao, and D.H. Sherman J. Am. Chem. Soc. 123 2001 6712