The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation: A single-center, randomized, prospective study of a calcium phosphate mouth rinse + standard of care versus standard of care

Supportive Care in Cancer

Volumn 21, Issue 10, 2013, Pages 2663-2670

  Lambrecht, Maarten ^a   Mercier, Carole ^a   Geussens, Yasmyne ^a,b   Nuyts, Sandra ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b Iridium Cancer Network GZA   (Belgium)

Author keywords

Calcium phosphate rinse; Chemoradiation; Head and neck cancer; Mucositis; Oral care; Radiotherapy

Indexed keywords

BUPRENORPHINE; CALCIUM PHOSPHATE; CAPHOSOL; CISPLATIN; DOCETAXEL; FLUCONAZOLE; FLUOROURACIL; MOUTHWASH; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; TRAMADOL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER PATIENT; CHEMORADIOTHERAPY; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG EFFICACY; DYSPHAGIA; FEMALE; HEAD AND NECK CANCER; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MALE; MOUTH HYGIENE; MOUTH PAIN; ORAL MUCOSITIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; VISUAL ANALOG SCALE;

ADULT; AGED; CALCIUM PHOSPHATES; CHEMORADIOTHERAPY; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTHWASHES; PAIN; PAIN MEASUREMENT; PROSPECTIVE STUDIES; RADIATION INJURIES; STANDARD OF CARE; STOMATITIS;

EID: 84884287708     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-013-1829-0     Document Type: Article

References (16)

1. Elting LS, Cooksley CD, Chambers MS et al (2007) Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. Int J Radiat Oncol Biol Phys 68:1110-1120
2. Barasch A, Peterson DE (2003) Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral Oncol 39:91-100
3. Russo G, Haddad R, Posner M et al (2008) Radiation treatment breaks and ulcerative mucositis in head and neck cancer. Oncologist 13:886-898
4. Peterson DE, Bensadoun RJ, Roila F (2011) Management of oral and gastrointestinal mucositis: ESMO Clinical Practice Guidelines. Ann Oncol 22(Suppl 6):vi78-vi84
5. Keefe DM, Schubert MM, Elting LS et al (2007) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109:820-831
6. Rosenthal DI, Trotti A (2009) Strategies for managing radiation-induced mucositis in head and neck cancer. Semin Radiat Oncol 19:29-34
7. Clarkson JE, Worthington HV, Furness S et al. (2010) Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev 2010; CD001973-
8. Hensley ML, Hagerty KL, Kewalramani T et al (2009) American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants. J Clin Oncol 27:127-145
9. Papas AS, Clark RE, Martuscelli G et al (2003) A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 31:705-712
10. Wasko-Grabowska A, Rzepecki P, Oborska S et al (2011) Efficiency of supersaturated calcium phosphate mouth rinse treatment in patients receiving high-dose melphalan or BEAM prior to autologous blood stem cell transplantation: a single-center experience. Transplant Proc 43:3111-3113
11. Stokman MA, Burlage FR, Spijkervet FK (2012) The effect of a calcium phosphate mouth rinse on (chemo) radiation induced oral mucositis in head and neck cancer patients: a prospective study. Int J Dent Hyg 10:175-180
12. Sonis ST, Elting LS, Keefe D et al (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100:1995-2025
13. Vagliano L, Feraut C, Gobetto G et al (2011) Incidence and severity of oral mucositis in patients undergoing haematopoietic SCT - results of a multicentre study. Bone Marrow Transplant 46:727-732
14. Sanguineti G, Sormani MP, Marur S et al (2012) Effect of radiotherapy and chemotherapy on the risk of mucositis during intensity-modulated radiation therapy for oropharyngeal cancer. Int J Radiat Oncol Biol Phys 83:235-242
15. Narayan S, Lehmann J, Coleman MA et al (2008) Prospective evaluation to establish a dose response for clinical oral mucositis in patients undergoing head-and-neck conformal radiotherapy. Int J Radiat Oncol Biol Phys 72:756-762
16. Vera-Llonch M, Oster G, Hagiwara M et al (2006) Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer 106:329-336