Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms

FEBS Letters

Volumn 587, Issue 19, 2013, Pages 3281-3287

  Skrzypski, M ^a,b   Kakkassery, M ^a   Mergler, S ^a   Grotzinger C ^a   Khajavi, N ^a   Sassek, M ^b   Szczepankiewicz, D ^b   Wiedenmann, B ^a   Nowak, K W ^b   Strowski, M Z ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Beta cell; Calcium; INS 1E; Insulin secretion; TRP; TRPV4

Indexed keywords

4ALPHA PHORBOL DIDECANOATE; CALCIUM; GLUCOSE; HYPOTONIC SOLUTION; INSULIN; MESSENGER RNA; RUTHENIUM RED; VANILLOID RECEPTOR 4;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; GENE EXPRESSION; HEAT TREATMENT; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

4Α-PDD; BETA CELL; CALCIUM; CAMP; CYCLIC ADENOSINE MONOPHOSPHATE; HIAPP; HUMAN ISLET AMYLOID POLYPEPTIDE; INS-1E; INSULIN SECRETION; KREBS-RINGER-HEPES BUFFER; KRHB; NON-TARGETING SIRNA; NT SIRNA; PKC; PROTEIN KINASE C; SIRNA; SMALL INTERFERING RNA; THE PHORBOL ESTER 4Α-PHORBOL 12,13-DIDECANOATE; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 4; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRP; TRPM2; TRPV4;

CALCIUM; CELL LINE; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; TRPV CATION CHANNELS;

EID: 84884287516     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.08.025     Document Type: Article

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