Metabolic syndrome and right ventricle: An updated review

European Journal of Internal Medicine

Volumn 24, Issue 7, 2013, Pages 608-616

  Tadic, Marijana ^a   Ivanovic, Branislava ^b   Cuspidi, Cesare ^c  

^a University Clinical Center   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Diabetes; Dyslipidemia; Hypertension; Metabolic syndrome; Obesity; Right ventricle

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; OXYGEN RADICAL; TRIACYLGLYCEROL;

ABDOMINAL OBESITY; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DYSLIPIDEMIA; ELECTROCARDIOGRAM; ESSENTIAL HYPERTENSION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HEART CATHETERIZATION; HEART HEMODYNAMICS; HEART MUSCLE OXYGEN CONSUMPTION; HEART OUTPUT; HEART RIGHT VENTRICLE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HUMAN; INSULIN RESISTANCE; LUNG ARTERY PRESSURE; META ANALYSIS; METABOLIC SYNDROME X; OXIDATIVE STRESS; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SLEEP DISORDERED BREATHING; SYSTEMATIC REVIEW; SYSTEMIC VASCULAR RESISTANCE; SYSTOLIC BLOOD PRESSURE; THORAX RADIOGRAPHY; THREE DIMENSIONAL ECHOCARDIOGRAPHY; TISSUE DOPPLER IMAGING; TRIACYLGLYCEROL BLOOD LEVEL; TWO DIMENSIONAL ECHOCARDIOGRAPHY; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

COMPUTED TOMOGRAPHY; CT; DIABETES; DYSLIPIDEMIA; GLYCOSYLATED HEMOGLOBIN; HBA1C; HDL-C; HIGH-DENSITY LIPOPROTEIN CHOLESTEROL; HOMA; HOMEOSTASIS MODEL ASSESSMENT; HYPERTENSION; LEFT VENTRICLE; LV; MAGNETIC RESONANCE; MET; METABOLIC EQUIVALENT; METABOLIC SYNDROME; MR; MS; OBESITY; RAAS; RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM; RIGHT VENTRICLE; RV; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPECT; TAPSE; TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION;

DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; HUMANS; HYPERTENSION; METABOLIC SYNDROME X; OBESITY; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 84884287033     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2013.08.007     Document Type: Review

References (104)

1. C. Cuspidi, C. Valerio, C. Sala, F. Negri, A. Esposito, and M. Masaidi Metabolic syndrome and biventricular hypertrophy in essential hypertension J Hum Hypertens 23 2009 168 175
2. M. Tadic, B. Ivanovic, and I. Grozdic Metabolic syndrome impacts the right ventricle: true or false? Echocardiography 28 2011 530 538
3. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) JAMA 285 2001 2486 2497
4. S.M. Grundy, J.I. Cleeman, S.R. Daniels, K.A. Donato, R.H. Eckel, and B.A. Franklin Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung and Blood Institute scientific statement Circulation 112 2005 2735 2752
5. K.G. Alberti, P. Zimmet, J. Shaw, and the IDF Epidemiology Task Force Consensus Group The metabolic syndrome: a new worldwide definition Lancet 366 2005 1059 1062
6. F. Haddad, S.A. Hunt, D.N. Rosenthal, and D.J. Murphy Right ventricular function in cardiovascular disease, part I: anatomy, physiology, aging, and functional assessment of the right ventricle Circulation 117 2008 1436 1448
7. Tigen, T. Karaahmet, C. Cevik, E. Gurel, S. Pala, and B. Mutlu Prognostic utility of right ventricular systolic functions assessed by tissue Doppler imaging in dilated cardiomyopathy and its correlation with plasma NT-pro-BNP levels Congest Heart Fail 15 2009 234 239
8. L. Werko, and H. Lagerlof Studies on the circulation in man. IV. Cardiac output and blood pressure in the right auricle, right ventricle and pulmonary artery in patients with hypertensive cardiovascular disease Acta Med Scand 133 1949 427 436
9. M.T. Olivari, C. Fiorentini, A. Polese, and M.D. Guazzi Pulmonary haemodynamics and right ventricular function in hypertension Circulation 58 1978 1185 1190
10. M.A. Alpert, J.H. Bauer, B.M. Parker, J.F. Sanfelippo, and C.S. Brooks Pulmonary hemodynamics in systemic hypertension South Med J 78 1985 784 789
11. J. Ferlinz Right ventricular performance in essential hypertension Circulation 61 1980 156 162
12. C. Fiorentini, P. Barbier, C. Galli, A. Loaldi, G. Tamborini, and E. Tosi Pulmonary vascular overreactivity in systemic hypertension. A pathophysiological link between the greater and the lesser circulation Hypertension 7 1985 995 1002
13. R. Pedrinelli, M.L. Canale, C. Giannini, E. Talini, G. Penno, and G. Dell'Omo Right ventricular dysfunction in early systemic hypertension: a tissue Doppler imaging study in patients with high-normal and mildly increased arterial blood pressure J Hypertens 28 2010 615 621
14. R. Fagard, P. Lijnen, J. Staessen, J. Verschuere, and A. Amery The pulmonary circulation in essential systemic hypertension Am J Cardiol 61 1988 1061 1065
15. R.T. Schermuly, H.A. Ghofrani, M.R. Wilkins, and F. Grimminger Mechanisms of disease: pulmonary arterial hypertension Nat Rev Cardiol 8 2011 443 455
16. G.D. Buckberg, and RESTORE Group The ventricular septum: the lion of right ventricular function, and its impact on right ventricular restoration Eur J Cardiothorac Surg 29 2006 S272 S278
17. J.S. Gottdiener, J.A. Gay, B.J. Maron, and R.D. Fletcher Increased right ventricular wall thickness in left ventricular pressure overload: echocardiographic determination of hypertrophic response of the "nonstressed" ventricle J Am Coll Cardiol 6 1985 550 555
18. B.D. Nunez, F.H. Messerli, C. Amodeo, G.E. Garavaglia, R.E. Schmieder, and E.D. Frohlich Biventricular cardiac hypertrophy in essential hypertension Am Heart J 114 1987 813 818
19. L. Lonati, C. Cuspidi, M. Bocciolone, L. Sampieri, L. Boselli, and G. Leonetti Comparison of the echocardiographic effects induced by physiological ageing and hypertension on the left and right ventricle J Hypertens Suppl 11 1993 S100 S101
20. M. Galderisi, S. Severino, P. Caso, S. Cicala, A. Petrocelli, and L. De Simone Right ventricular myocardial diastolic dysfunction in different kinds of cardiac hypertrophy: analysis by pulsed Doppler tissue imaging Ital Heart J 2 2001 912 920
21. C. Cuspidi, L. Sampieri, L. Angioni, L. Boselli, R. Bragato, and G. Leonetti Right ventricular wall thickness and function in hypertensive patients with and without left ventricular hypertrophy: echo-Doppler study J Hypertens Suppl 7 1989 S108 S109
22. A.A. Akintunde, P.O. Akinwusi, O.B. Familoni, and O.G. Opadijo Effect of systemic hypertension on right ventricular morphology and function: an echocardiographic study Cardiovasc J Afr 21 2010 252 256
23. S. Cicala, M. Galderisi, P. Caso, A. Petrocelli, A. D'Errico, and O. de Divitiis Right ventricular diastolic dysfunction in arterial systemic hypertension: analysis by pulsed tissue Doppler Eur J Echocardiogr 3 2002 135 142
24. M. Tadic, B. Ivanovic, N. Kostic, D. Simic, D. Matic, and V. Celic Metabolic syndrome and left ventricular function: is the number of criteria actually important? Med Sci Monit 18 2012 CR282 CR289
25. R. Pedrinelli, M.L. Canale, C. Giannini, E. Talini, G. Dell'Omo, and V. Di Bello Abnormal right ventricular mechanics in early systemic hypertension: a two-dimensional strain imaging study Eur J Echocardiogr 11 2010 738 742
26. C. Cuspidi, C. Sala, M.L. Muiesan, N. De Luca, and G. Schillaci Working Group on Heart, Hypertension of the Italian Society of Hypertension. Right ventricular hypertrophy in systemic hypertension: an updated review of clinical studies J Hypertens 31 5 May 2013 858 865
27. A. Akkoç, B. Uçaman, and H. Kaymak Right and left ventricular diastolic filling parameters in essential hypertension Asian Cardiovasc Thorac Ann 7 1999 214 220
28. W. Myśliński, J. Mosiewicz, E. Ryczak, W. Barud, A. Biłan, and R. Palusiński Right ventricular function in systemic hypertension J Hum Hypertens 12 1998 149 155
29. G. Todiere, D. Neglia, S. Ghione, E. Fommei, P. Capozza, and G. Guarini Right ventricular remodelling in systemic hypertension: a cardiac MRI study Heart 97 2011 1257 1261
30. G.B. Habib, and W.A. Zoghbi Doppler assessment of right ventricular filling dynamics in systemic hypertension: comparison with left ventricular filling Am Heart J 124 1992 1313 1320
31. A. Cittadini, S. Fazio, H. Stromer, A. Cuocolo, D. Sabatini, and M. Imbriaco Optimal determination of right ventricular filling dynamics in systemic hypertension Am Heart J 130 1995 1074 1082
32. C. Cuspidi, F. Negri, V. Giudici, C. Valerio, C. Valerio, and S. Meani Prevalence and clinical correlates of right ventricular hypertrophy in essential hypertension J Hypertens 27 2009 854 860
33. M.V. Tadic, B.A. Ivanovic, and V.P. Celic Does a nondipping pattern impact the right ventricle in hypertensive patients? Blood Press Monit 17 2012 47 54
34. H. Chahal, C. Johnson, H. Tandri, A. Jain, W.G. Hundley, and R.G. Barr Relation of cardiovascular risk factors to right ventricular structure and function as determined by magnetic resonance imaging (results from the multi-ethnic study of atherosclerosis) Am J Cardiol 106 2010 110 116
35. B.A. Ivanovic, M.V. Tadic, and V.P. Celic To dip or not to dip? The unique relationship between different blood pressure patterns and cardiac function and structure J Hum Hypertens 2011 10.1038/jhh.2011.83
36. M.M. Tumuklu, U. Erkorkmaz, and A. Ocal The impact of hypertension and hypertension-related left ventricle hypertrophy on right ventricle function Echocardiography 24 2007 374 384
37. C. Cuspidi, F. Negri, V. Giudici, C. Sala, and G. Mancia Impaired midwall mechanics and biventricular hypertrophy in essential hypertension Blood Press 19 2010 234 239
38. G.P. Vyssoulis, E.A. Karpanou, S.M. Kyvelou, D.N. Adamopoulos, A.D. Deligeorgis, and P.G. Spanos Nocturnal blood pressure fall and metabolic syndrome score in hypertensive patients Blood Press Monit 12 2007 351 356
39. G. Pechlivanidis, L. Mantziari, G. Giannakoulas, H. Dimitroula, H. Styliadis, and H. Karvounis Effects of renin-angiotensin system inhibition on right ventricular function in patients with mild essential hypertension J Renin Angiotensin Aldosterone Syst 12 2011 358 364
40. C.E. Ventetuolo, J.A. Lima, R.G. Barr, M.R. Bristow, E. Bagiella, and H. Chahal The renin-angiotensin system and right ventricular structure and function: the MESA-right ventricle study Pulm Circ 2 2012 379 386
41. R.S. Vasan, J.C. Evans, E.J. Benjamin, D. Levy, M.G. Larson, and J. Sundstrom Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study Hypertension 43 2004 957 962
42. H. Urata, B. Healy, R.W. Stewart, F.M. Bumpus, and A. Husain Angiotensin II - forming pathways in normal and failing human hearts Circ Res 66 1990 883 890
43. M.E. Young, P. Mcnulty, and H. Taegtmeyer Adaptation and maladaptation of the heart in diabetes: part II potential mechanisms Circulation 105 2002 1861 1870
44. S.M. Factor, T. Minase, and E.H. Sonnenblick Clinical and morphological features of human hypertensive-diabetic cardiomyopathy Am Heart J 99 1980 446 458
45. G.Z. Kalil, and W.G. Haynes Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications Hypertens Res 35 2012 4 16
46. C. Voulgari, D. Papadogiannis, and N. Tentolouris Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies Vasc Health Risk Manag 6 2010 883 903
47. S.A. Hayat, B. Patel, R.S. Khattar, and R.A. Malik Diabetic cardiomyopathy: mechanisms, diagnosis and treatment Clin Sci (Lond) 107 2004 539 557
48. T.D. Karamitsos, H.I. Karvounis, E.G. Dalamanga, C.E. Papadopoulos, T.P. Didangellos, and D.T. Karamitsos Early diastolic impairment of diabetic heart: the significance of right ventricle Int J Cardiol 114 2007 218 223
49. Y. Tayyareci, S. Yurdakul, G. Tayyareci, Y. Nisanci, B. Umman, and Z. Buǧra Impact of myocardial acceleration during isovolumic contraction in evaluating subclinical right ventricular systolic dysfunction in type 2 diabetes mellitus patients Echocardiography 27 2010 1211 1218
50. A.C. Ng, V. Delgado, M. Bertini, R.W. van der Meer, L.J. Rijzewijk, and S. Hooi Ewe Myocardial steatosis and biventricular strain and strain rate imaging in patients with type 2 diabetes mellitus Circulation 122 2010 2538 2544
51. W. Kosmala, M. Przewlocka-Kosmala, and W. Mazurek Subclinical right ventricular dysfunction in diabetes mellitus - an ultrasonic strain/strain rate study Diabet Med 24 2007 656 663
52. W. Kosmala, P. Colonna, M. Przewlocka-Kosmala, and W. Mazurek Right ventricular dysfunction in asymptomatic diabetic patients Diabetes Care 27 2004 2736 2738
53. G. EIshahedf, M. Ahmed, S. Beblawy, H. Kama, M. lsmaie, and O. Bin Zheidan Evaluation of right and left ventricular systolic and diastolic function in patients with type I diabetes using echocardiography and tissue Doppler imaging Suez Canal Univ Med J 11 2008 65 74
54. S.R. Mittal Right ventricular functions in patients with type 2 diabetes below 50 years J Assoc Physicians India 55 2007 599 600
55. M. Tadic, B. Ivanovic, and M. Petrovic Is gender responsible for everything? The relationship between sex and right ventricular remodeling in metabolic syndrome Echocardiography 2013 10.1111/echo.12135
56. M.A. Alpert Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome Am J Med Sci 321 2001 225 236
57. U.C. Guidry, L.A. Mendes, J.C. Evans, D. Levy, G.T. O'Connor, and M.G. Larson Echocardiographic features of the right heart in sleep-disordered breathing: the Framingham Heart study Am J Respir Crit Care Med 164 2001 933 938
58. S.E. Friedman, and B.W. Andrus Obesity and pulmonary hypertension: a review of pathophysiologic mechanisms J Obes 50 2012 52 74
59. M. Imada, N. Funabashi, M. Asano, M. Uehara, Y. Hori, and M. Ueda Epidemiology of fat replacement of the right ventricular myocardium determined by multislice computed tomography using a logistic regression model Int J Cardiol 119 2007 410 413
60. C.Y. Wong, T. O'Moore-Sullivan, R. Leano, C. Hukins, C. Jenkins, and T.H. Marwick Association of subclinical right ventricular dysfunction with obesity J Am Coll Cardiol 47 2006 611 616
61. P.G. Danias, N.A. Tritos, M. Stuber, K.V. Kissinger, C.J. Salton, and W.J. Manning Cardiac structure and function in the obese: a cardiovascular magnetic resonance imaging study J Cardiovasc Magn Reson 5 2003 431 438
62. H. Chahal, R.L. McClelland, H. Tandri, A. Jain, E.B. Turkbey, and W.G. Hundley Obesity and right ventricular structure and function: the MESA-right ventricle study Chest 141 2012 388 395
63. O.J. Rider, S.E. Petersen, J.M. Francis, M.K. Ali, L.E. Hudsmith, and M.R. Robinson Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity Heart 97 2011 203 208
64. M.E. Otto, M. Belohlavek, B. Khandheria, G. Gilman, A. Svatikova, and V. Somers Comparison of right and left ventricular function in obese and nonobese men Am J Cardiol 93 2004 1569 1572
65. C. Zeybek, C. Aktuglu-Zeybek, H. Onal, S. Altay, A. Erdem, and A. Celebi Right ventricular subclinical diastolic dysfunction in obese children: the effect of weight reduction with a low-carbohydrate diet Pediatr Cardiol 30 2009 946 953
66. O. Yildirimturk, Y. Tayyareci, and S. Aytekin The impact of body mass index on right ventricular systolic functions in normal and mildly obese healthy patients: a velocity vector imaging study Echocardiography 28 2011 746 752
67. R.V. Shah, S.A. Abbasi, B. Heydari, C. Rickers, D.R. Jacobs Jr., and L. Wang Insulin resistance, subclinical left ventricular remodeling, and the obesity paradox: MESA (Multi-Ethnic Study of Atherosclerosis) J Am Coll Cardiol 61 2013 1698 1706
68. R.R. Jhaveri, K.K. Pond, T.H. Hauser, K.V. Kissinger, L. Goepfert, and B. Schneider Cardiac remodeling after substantial weight loss: a prospective cardiac magnetic resonance study after bariatric surgery Surg Obes Relat Dis 5 2009 648 652
69. M. Syed, C. Rosati, M.T. Torosoff, M. El-Hajjar, P. Feustel, and S. Alger The impact of weight loss on cardiac structure and function in obese patients Obes Surg 19 2009 36 40
70. T. Owan, E. Avelar, K. Morley, R. Jiji, N. Hall, and J. Krezowski Favorable changes in cardiac geometry and function following gastric bypass surgery: 2-year follow-up in the Utah obesity study J Am Coll Cardiol 57 2011 732 739
71. H.J. Willens, S.C. Chakko, P. Byers, J.A. Chirinos, E. Labrador, and J.C. Castrillon Effects of weight loss after gastric bypass on right and left ventricular function assessed by tissue Doppler imaging Am J Cardiol 95 2005 1521 1524
72. C.A. Garza, P.A. Pellikka, V.K. Somers, M.G. Sarr, M.L. Collazo-Clavell, and Y. Korenfeld Structural and functional changes in left and right ventricles after major weight loss following bariatric surgery for morbid obesity Am J Cardiol 105 2010 550 556
73. A.L. Orhan, N. Uslu, S.U. Dayi, Z. Nurkalem, F. Uzun, and H.B. Erer Effects of isolated obesity on left and right ventricular function: a tissue Doppler and strain rate imaging study Echocardiography 27 2010 236 243
74. M.M. Barbosa, A.M. Beleigoli, Diniz M. de Fatima, C.V. Freire, A.L. Ribeiro, and M.C. Nunes Strain imaging in morbid obesity: insights into subclinical ventricular dysfunction Clin Cardiol 34 2011 288 293
75. 2) Am J Cardiol 94 2004 1087 1090
76. C. Her, T. Cerabona, M. Bairamian, and K.E. McGoldrick Right ventricular systolic function is not depressed in morbid obesity Obes Surg 16 2006 1287 1293
77. K. Tigen, T. Karaahmet, E. Gürel, C. Cevik, F. Yilmaz, and A. Avci The utility of heart rate recovery to predict right ventricular systolic dysfunction in patients with obesity Anadolu Kardiyol Derg 9 2009 473 479
78. R.S. Velagaleti, P. Gona, D. Levy, J. Aragam, M.G. Larson, and G.H. Tofler Relations of biomarkers representing distinct biological pathways to left ventricular geometry Circulation 118 2008 2252 2258
79. S.M. Kawut, R.G. Barr, W.C. Johnson, H. Chahal, H. Tandri, and A. Jain Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV study Biomarkers 15 2010 731 738
80. A.E. Malavazos, M.M. Corsi, F. Ermetici, C. Coman, F. Sardanelli, and A. Rossi Proinfammatory cytokines and cardiac abnormalities in uncomplicated obesity: relationship with abdominal fat deposition Nutr Metab Cardiovasc Dis 17 2007 294 302
81. C. Villard, D. Wågsäter, J. Swedenborg, P. Eriksson, and R. Hultgren Biomarkers for abdominal aortic aneurysms from a sex perspective Gend Med 9 2012 259 266
82. S.M. Grundy Hypertriglyceridemia, atherogenic dyslipidemia and the metabolic syndrome Am J Cardiol 81 1988 18B 25B
83. M.A. Austin, and K.L. Edwards Small dense low density lipoproteins, the insulin resistance syndrome, and non-insulin dependent diabetes Curr Opin Lipidol 7 1996 167 171
84. L. Fuentes, A.D. Waggoner, Al Brown, and V.G. Dávila-Román Plasma triglyceride level is an independent predictor of altered left ventricular relaxation J Am Soc Echocardiogr 18 2005 1285 1291
85. S. Hammer, R.W. van der Meer, H.J. Lamb, H.H. de Boer, J.J. Bax, and A. de Roos Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus Am J Physiol Endocrinol Metab 295 2008 E714 E718
86. J. Steinberger, C. Moorehead, V. Katch, and A.P. Rocchini Relationship between insulin resistance and abnormal lipid profile in obese adolescents J Pediatr 126 1995 690 695
87. D.M. Miao, P. Ye, W.K. Xiao, P. Gao, J.Y. Zhang, and H.M. Wu Influence of low high-density lipoprotein cholesterol on arterial stiffening and left ventricular diastolic dysfunction in essential hypertension J Clin Hypertens (Greenwich) 13 2011 710 715
88. F. Anan, H. Yonemochi, T. Masaki, N. Takahashi, N. Fukunaga, and Y. Teshima High-density lipoprotein cholesterol and insulin resistance are independent and additive markers of left ventricular hypertrophy in essential hypertension Hypertens Res 30 2007 125 131
89. L. Lin, H. Gong, J. Ge, G. Jiang, N. Zhou, and L. Li High density lipoprotein downregulates angiotensin II type 1 receptor and inhibits angiotensin II-induced cardiac hypertrophy Biochem Biophys Res Commun 404 2011 28 33
90. G. Lupattelli, S. Marchesi, R. Lombardini, D. Siepi, F. Bagaglia, and M. Pirro Mechanisms of high-density lipoprotein cholesterol effects on the endothelial function in hyperlipemia Metabolism 52 2003 1191 1195
91. F. Perticone, R. Maio, R. Ceravolo, C. Cosco, C. Cloro, and P.L. Mattioli Relationship between left ventricular mass and endothelium-dependent vasodilation in never-treated hypertensive patients Circulation 99 1999 1991 1996
92. O. Karakurt, S. Oztekin, N. YazIhan, and R. Akdemir Impaired right ventricular functions in metabolic syndrome patients with preserved left ventricular ejection fraction Turk Kardiyol Dern Ars 39 2011 549 556
93. M.K. Tigen, T. Karaahmet, E. Gürel, C. Dündar, S. Pala, and C. Cevik The role of isovolumic acceleration in predicting subclinical right and left ventricular systolic dysfunction in hypertensive obese patients Turk Kardiyol Dern Ars 39 2011 9 15
94. M. Masaidi, C. Cuspidi, F. Negri, V. Giudici, C. Sala, and A. Zanchetti Left and right ventricular structural changes in obese hypertensives Blood Press 18 2009 23 29
95. K. Putnam, R. Shoemaker, F. Yiannikouris, and L.A. Cassis The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome Am J Physiol Heart Circ Physiol 302 2012 H1219 H1230
96. P. Holvoet Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease Verh K Acad Geneeskd Belg 70 2008 193 219
97. X. Lu, C.Q. Dang, X. Guo, S. Molloi, C.D. Wassall, and M.D. Kemple Elevated oxidative stress and endothelial dysfunction in right coronary artery of right ventricular hypertrophy J Appl Physiol 110 2011 1674 1681
98. P. Crosswhite, and Z. Sun Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension J Hypertens 28 2010 201 212
99. M. Leggio, G. Cruciani, L. Sgorbini, A. Mazza, M.G. Bendini, and M. Pugliese Obesity-related adjunctive systo-diastolic ventricular dysfunction in patients with hypertension: echocardiographic assessment with tissue Doppler velocity and strain imaging Hypertens Res 34 2011 468 473
100. E.R. Valsangiacomo Buechel, and L.L. Mertens Imaging the right heart: the use of integrated multimodality imaging Eur Heart J 33 2012 949 960
101. J.R. Mangion Right ventricular imaging by two-dimensional and three-dimensional echocardiography Curr Opin Cardiol 25 2010 423 429
102. K. Goetschalckx, F. Rademakers, and J. Bogaert Right ventricular function by MRI Curr Opin Cardiol 25 2010 451 455
103. D. Gopalan Right heart on multidetector CT Br J Radiol 84 2011 S306 S323
104. J.D. Rich, and R.P. Ward Right-ventricular function by nuclear cardiology Curr Opin Cardiol 25 2010 445 450