Cerebrospinal fluid lactate and pyruvate concentrations and their ratio

Clinical Biochemistry

Volumn 46, Issue 7-8, 2013, Pages 694-697

  Zhang, Wan Ming ^a   Natowicz, Marvin R ^a,b,c,d,e  

^a Pathology and Laboratory Medicine Institute   (United States)

^b CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^c Genomic Medicine Institute   (United States)

^d Pediatric Institute   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Cerebrospinal fluid; CSF; Lactate; Pyruvate

Indexed keywords

ALANINE; GLUCOSE; LACTIC ACID; OLIGOCLONAL BAND; PROTEIN; PYRUVIC ACID;

AGE; ARTICLE; BASAL GANGLION; CELL COUNT; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID CYTOLOGY; CEREBROSPINAL FLUID LACTATE LEVEL; CEREBROSPINAL FLUID LEVEL; CEREBROSPINAL FLUID PYRUVATE LEVEL; CHILD; FEMALE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; REFERENCE VALUE; SCHOOL CHILD; ADOLESCENT; ADULT; INFANT; MIDDLE AGED; PRESCHOOL CHILD;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LACTIC ACID; MALE; MIDDLE AGED; PYRUVIC ACID; REFERENCE VALUES;

EID: 84884284170     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.11.008     Document Type: Article

References (23)

1. Gladden L.B. Lactate metabolism: a new paradigm for the third millennium. J Physiol 2004, 558:5-30.
2. Pellerin L. Brain energetics (thought needs food). Curr Opin Clin Nutr Metab Care 2008, 11:701-708.
3. Hutchesson A., Preece M.A., Gray G., Green A. Measurement of lactate in cerebrospinal fluid in investigation of inherited metabolic disease. Clin Chem 1997, 43:158-161.
4. Benoist J.-F., Albeti C., Leclercq S., Rigal O., Jean-Louis R., de Baulny H.O., et al. Cerebrospinal fluid lactate and pyruvate concentrations and their ratio in children: age-related reference intervals. Clin Chem 2003, 49:487-494.
5. Magner M., Szentivanyi K., Svandova I., Jesina P., Tesarova M., Honzik T., et al. Elevated CSF lactate is a reliable marker of mitochondrial disorders in children even after brief seizures. Eur J Paediatr Neurol 2011, 15:101-108.
6. Yamada K., Toribe Y., Yanagihara K., Mano T., Akagi M., Suzuki Y. Diagnostic accuracy of blood and CSF lactate in identifying children with mitochondrial diseases affecting the central nervous system. Brain Dev 2012, 34:92-97.
7. Patel K.P., O'Brien T.W., Subramony S.H., Shuster J., Stacpoole P.W. The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients. Mol Genet Metab 2012, 105:34-43.
8. Huy N.T., Thao N.T.H., Diep D.T.N., Kikuchi M., Zamora J., Hirayama K. Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis. Crit Care 2010, 14:R240.
9. Chow S.L., Rooney Z.J., Cleary M.A., Clayton P.T., Leonard J.V. The significance of elevated CSF lactate. Arch Dis Child 2005, 90:1188-1189.
10. Thurston J.H., Hauhart R.E., Seltzer J.L., McDougal D.B. Fluorometric determination of pyruvate and α-ketoglutarate in cerebrospinal fluid and plasma of infants and children. Arch Neurol 1976, 33:764-768.
11. Vamosi B., Dioszeghy P., Molnar L. Lactate and pyruvate content of the human cisternal cerebrospinal fluid. Arch Psychiatr Nervenkr 1982, 232:521-532.
12. Lamers K.J.B., Doesburg W.H., Gabreels F.J.M., Romson A.C., Lemmens W.A.J.G., Wevers R.A., et al. CSF concentration and CSF/blood ratio of fuel related components in children after prolonged fasting. Clin Chim Acta 1987, 167:135-145.
13. Posner J.B., Plum F. Independence of blood and cerebrospinal fluid lactate. Arch Neurol 1967, 16:492-496.
14. Fernandez F., Verdu A., Quero J., Ferreiros M.C., Daimiel E., Roche M.C., et al. Cerebrospinal fluid lactate levels in term infants with perinatal hypoxia. Pediatr Neurol 1986, 2:39-42.
15. Calabrese V.P., Gruemer H.D., James K., Hranowsky N., DeLorenzo R.J. Cerebrospinal fluid lactate levels and prognosis in status epilepticus. Epilepsia 1991, 32:816-821.
16. Cabeca H.L.S., Gomes H.R., dos Ramos Machado L., Livramento J.A. Dosage of lactate in the cerebrospinal fluid in infectious diseases of the central nervous system. Arq Neuropsiquiatr 2001, 59:843-848.
17. Pryce J.D., Gant P.W., Saul K.J. Normal concentrations of lactate, glucose, and protein in cerebrospinal fluid, and the diagnostic implications of abnormal concentrations. Clin Chem 1970, 16:562-565.
18. Cameron P.D., Boyce J.M.H., Ansari B.M. Cerebrospinal fluid lactate in meningitis and meningococcaemia. J Infect 1993, 26:245-252.
19. Jesse S., Brettschneider J., Sussmuth S.D., Landwehrmeyer B.G., von Arnim C.A.F., Ludolph A.C., et al. Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases. J Neurol 2011, 258:1034-1041.
20. Knight J.A., Dudek S.M., Haymond R.E. Early (chemical) diagnosis of bacterial meningitis - cerebrospinal fluid glucose, lactate, and lactate dehydrogenase compared. Clin Chem 1981, 27:1431-1434.
21. Leen W.G., Willemsen M.A., Wevers R.A., Verbeek M.M. Cerebrospinal fluid glucose and lactate: age-specific reference values and implications for clinical practice. PLoS One 2012, 7:e42745.
22. ABL800 FLEX reference manual. Publication 201104 2011, Radiometer Medical ApS, Denmark.
23. Sigma Technical Bulletin No. 726-UV 1996, Sigma Chemical Co., St. Louis, MO.