-
2
-
-
0025710611
-
NIH consensus conference
-
Adjuvant therapy for patients with colon and rectal cancer
-
NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA. 264:1444-50, 1990.
-
(1990)
JAMA
, vol.264
, pp. 1444-1450
-
-
-
4
-
-
0035901059
-
Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery
-
11229667 10.1016/S0140-6736(00)04040-X 1:STN:280:DC%2BD3M7lt1Shtg%3D%3D
-
Beets-Tan RG, Beets GL, Vliegen RF, et al. Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet. 2001;357:497-504.
-
(2001)
Lancet
, vol.357
, pp. 497-504
-
-
Beets-Tan, R.G.1
Beets, G.L.2
Vliegen, R.F.3
-
5
-
-
33750071992
-
Diagnostic Accuracy of Preoperative Magnetic Resonance Imaging in Predicting Curative Resection of Rectal Cancer: Prospective Observational Study
-
MERCURY Study Group
-
MERCURY Study Group. Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ. 2006;333:779.
-
(2006)
BMJ
, vol.333
, pp. 779
-
-
-
6
-
-
0023836214
-
Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: Results from NSABP protocol R-01
-
3276900 10.1093/jnci/80.1.21 1:STN:280:DyaL1c7hvFSjsQ%3D%3D
-
Fisher B, Wolmark N, Rockette H, et al. Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01. J Natl Cancer Inst. 1988;80:21-9.
-
(1988)
J Natl Cancer Inst
, vol.80
, pp. 21-29
-
-
Fisher, B.1
Wolmark, N.2
Rockette, H.3
-
7
-
-
0021792174
-
Prolongation of the Disease-free Interval in Surgically Treated Rectal Carcinoma
-
Gastrointestinal Tumor Study Group Gastrointestinal Tumor Study Group
-
Gastrointestinal Tumor Study Group. Prolongation of the disease-free interval in surgically treated rectal carcinoma. Gastrointestinal Tumor Study Group. N Engl J Med. 1985;312:1465-72.
-
(1985)
N Engl J Med.
, vol.312
, pp. 1465-1472
-
-
-
8
-
-
6044226542
-
Preoperative versus postoperative chemoradiotherapy for rectal cancer
-
15496622 10.1056/NEJMoa040694 1:CAS:528:DC%2BD2cXovFSksbo%3D
-
Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731-40.
-
(2004)
N Engl J Med
, vol.351
, pp. 1731-1740
-
-
Sauer, R.1
Becker, H.2
Hohenberger, W.3
-
9
-
-
84860918386
-
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years
-
22529255 10.1200/JCO.2011.40.1836 1:CAS:528:DC%2BC38XpvVSgsbY%3D This recent report describes the long term outcomes of the German randomized trial comparing pre and postoperative therapy. It confirms the earlier report demonstrating superiority of preoperative treatment in terms of quality of life and local recurrence rate, but not overall survival
-
Sauer R, Liersch T, Merkel S, et al. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol. 2012;30:1926-33. This recent report describes the long term outcomes of the German randomized trial comparing pre and postoperative therapy. It confirms the earlier report demonstrating superiority of preoperative treatment in terms of quality of life and local recurrence rate, but not overall survival.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1926-1933
-
-
Sauer, R.1
Liersch, T.2
Merkel, S.3
-
10
-
-
61349188341
-
Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): A multicentre, randomised trial
-
19269519 10.1016/S0140-6736(09)60484-0
-
Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373:811-20.
-
(2009)
Lancet
, vol.373
, pp. 811-820
-
-
Sebag-Montefiore, D.1
Stephens, R.J.2
Steele, R.3
-
11
-
-
33748433241
-
Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer
-
16983741 10.1002/bjs.5506 1:STN:280:DC%2BD28rntlKlsQ%3D%3D
-
Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg. 2006;93:1215-23.
-
(2006)
Br J Surg
, vol.93
, pp. 1215-1223
-
-
Bujko, K.1
Nowacki, M.P.2
Nasierowska-Guttmejer, A.3
-
12
-
-
84869108068
-
Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04
-
23008301 10.1200/JCO.2012.42.9597 This is a recent Australian trial that demonstrated no statistically significant difference between short and long course preoperative radiation for locally advanced rectal cancer. However, non-significant trends favor the long course arm which had a lower rate of local recurrence. This effect was especially pronounced in the subgroup of patients at high risk
-
Ngan SY, Burmeister B, Fisher RJ, et al. Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04. J Clin Oncol. 2012;30:3827-33. This is a recent Australian trial that demonstrated no statistically significant difference between short and long course preoperative radiation for locally advanced rectal cancer. However, non-significant trends favor the long course arm which had a lower rate of local recurrence. This effect was especially pronounced in the subgroup of patients at high risk.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3827-3833
-
-
Ngan, S.Y.1
Burmeister, B.2
Fisher, R.J.3
-
13
-
-
80053103472
-
The impact of capecitabine and oxaliplatin in the preoperative multimodality treatment in patients with carcinoma of the rectum: NSABP R-04
-
This is the NSABP randomized trial that demonstrates that capecitabine and infusional 5FU are interchangeable and that oxaliplatin does not add incremental value to chemoradiation therapy
-
Roh MS, Yothers GA, O'Connell MJ, et al. The impact of capecitabine and oxaliplatin in the preoperative multimodality treatment in patients with carcinoma of the rectum: NSABP R-04. J Clin Oncol. 2011(suppl 29; abstr 3503). This is the NSABP randomized trial that demonstrates that capecitabine and infusional 5FU are interchangeable and that oxaliplatin does not add incremental value to chemoradiation therapy.
-
(2011)
J Clin Oncol.
, Issue.SUPPL. 29
-
-
Roh, M.S.1
Yothers, G.A.2
O'Connell, M.J.3
-
14
-
-
77950495945
-
Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: Results of the phase III trial ACCORD 12/0405-Prodige 2
-
20194850 10.1200/JCO.2009.25.8376 1:CAS:528:DC%2BC3cXmtVyhur0%3D
-
Gerard JP, Azria D, Gourgou-Bourgade S, et al. Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2. J Clin Oncol. 2010;28:1638-44.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1638-1644
-
-
Gerard, J.P.1
Azria, D.2
Gourgou-Bourgade, S.3
-
15
-
-
84884210821
-
Capecitabine versus 5-fluorouracil-based (neo)adjuvant chemoradiotherapy for locally advanced rectal cancer: Long-term results of a randomized
-
Proceedings of ASCO Annual Meeting phase III trial abstr 3504
-
Hofheinz R. Proceedings of ASCO Annual Meeting. 2011. Capecitabine versus 5-fluorouracil-based (neo)adjuvant chemoradiotherapy for locally advanced rectal cancer: Long-term results of a randomized, phase III trial. J Clin Oncol. 2011;29(suppl; abstr 3504).
-
(2011)
J Clin Oncol.
, vol.29
, Issue.SUPPL.
-
-
Hofheinz, R.1
-
16
-
-
45449085429
-
Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: Does delayed surgery have an impact on outcome?
-
18234443 10.1016/j.ijrobp.2007.11.035
-
Habr-Gama A, Perez RO, Proscurshim I, et al. Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome? Int J Radiat Oncol Biol Phys. 2008;71:1181-8.
-
(2008)
Int J Radiat Oncol Biol Phys
, vol.71
, pp. 1181-1188
-
-
Habr-Gama, A.1
Perez, R.O.2
Proscurshim, I.3
-
17
-
-
79959511682
-
Optimal timing of surgery after chemoradiation for advanced rectal cancer: Preliminary results of a multicenter, nonrandomized phase II prospective trial
-
21494121 10.1097/SLA.0b013e3182196e1f
-
Garcia-Aguilar J, Smith DD, Avila K, et al. Optimal timing of surgery after chemoradiation for advanced rectal cancer: preliminary results of a multicenter, nonrandomized phase II prospective trial. Ann Surg. 2011;254:97-102.
-
(2011)
Ann Surg
, vol.254
, pp. 97-102
-
-
Garcia-Aguilar, J.1
Smith, D.D.2
Avila, K.3
-
18
-
-
0019977792
-
The mesorectum in rectal cancer surgery-The clue to pelvic recurrence?
-
6751457 10.1002/bjs.1800691019 1:STN:280:DyaL3s%2Fitl2nsw%3D%3D
-
Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery-the clue to pelvic recurrence? Br J Surg. 1982;69:613-6.
-
(1982)
Br J Surg
, vol.69
, pp. 613-616
-
-
Heald, R.J.1
Husband, E.M.2
Ryall, R.D.3
-
19
-
-
0031859317
-
Rectal cancer: The Basingstoke experience of total mesorectal excision, 1978-1997
-
9711965 10.1001/archsurg.133.8.894 1:STN:280:DyaK1cznsFOrsQ%3D%3D
-
Heald RJ, Moran BJ, Ryall RD, et al. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg. 1998;133:894-9.
-
(1998)
Arch Surg
, vol.133
, pp. 894-899
-
-
Heald, R.J.1
Moran, B.J.2
Ryall, R.D.3
-
20
-
-
0036828878
-
Hospital and surgeon procedure volume as predictors of outcome following rectal cancer resection
-
12409664 10.1097/00000658-200211000-00008
-
Schrag D, Panageas KS, Riedel E, et al. Hospital and surgeon procedure volume as predictors of outcome following rectal cancer resection. Ann Surg. 2002;236:583-92.
-
(2002)
Ann Surg
, vol.236
, pp. 583-592
-
-
Schrag, D.1
Panageas, K.S.2
Riedel, E.3
-
21
-
-
78049382296
-
Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer
-
20629110 10.1002/bjs.7160 1:STN:280:DC%2BC3cfmsVCgtA%3D%3D
-
Jayne DG, Thorpe HC, Copeland J, et al. Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg. 2010;97:1638-45.
-
(2010)
Br J Surg
, vol.97
, pp. 1638-1645
-
-
Jayne, D.G.1
Thorpe, H.C.2
Copeland, J.3
-
22
-
-
33748676449
-
Chemotherapy with preoperative radiotherapy in rectal cancer
-
16971718 10.1056/NEJMoa060829 1:CAS:528:DC%2BD28XpsFKkur8%3D
-
Bosset JF, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006;355:1114-23.
-
(2006)
N Engl J Med
, vol.355
, pp. 1114-1123
-
-
Bosset, J.F.1
Collette, L.2
Calais, G.3
-
24
-
-
21244497388
-
Capecitabine as adjuvant treatment for stage III colon cancer
-
15987918 10.1056/NEJMoa043116 1:CAS:528:DC%2BD2MXls1SktL0%3D
-
Twelves C, Wong A, Nowacki MP, et al. Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med. 2005;352:2696-704.
-
(2005)
N Engl J Med
, vol.352
, pp. 2696-2704
-
-
Twelves, C.1
Wong, A.2
Nowacki, M.P.3
-
25
-
-
2542615200
-
Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
-
15175436 10.1056/NEJMoa032709 1:CAS:528:DC%2BD2cXks1Gjt78%3D
-
Andre T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350:2343-51.
-
(2004)
N Engl J Med
, vol.350
, pp. 2343-2351
-
-
Andre, T.1
Boni, C.2
Mounedji-Boudiaf, L.3
-
26
-
-
79551521053
-
Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08
-
20940184 10.1200/JCO.2010.30.0855 1:CAS:528:DC%2BC3MXhsFKhsLk%3D
-
Allegra CJ, Yothers G, O'Connell MJ, et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J Clin Oncol. 2011;29:11-6.
-
(2011)
J Clin Oncol
, vol.29
, pp. 11-16
-
-
Allegra, C.J.1
Yothers, G.2
O'Connell, M.J.3
-
27
-
-
84871734509
-
Postoperative adjuvant chemotherapy use in patients with stage II/III rectal cancer treated with neoadjuvant therapy: A national comprehensive cancer network analysis
-
23169502 10.1200/JCO.2011.40.3188 This study demonstrates that even at specialty cancer centers, many patients do not start or do not complete postoperative adjuvant systemic therapy
-
Khrizman P, Niland JC, ter Veer A, et al. Postoperative adjuvant chemotherapy use in patients with stage II/III rectal cancer treated with neoadjuvant therapy: a national comprehensive cancer network analysis. J Clin Oncol. 2013;31:30-8. This study demonstrates that even at specialty cancer centers, many patients do not start or do not complete postoperative adjuvant systemic therapy.
-
(2013)
J Clin Oncol
, vol.31
, pp. 30-38
-
-
Khrizman, P.1
Niland, J.C.2
Ter Veer, A.3
-
28
-
-
33644846344
-
Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer
-
16446339 10.1200/JCO.2005.04.4875 1:CAS:528:DC%2BD28XhvFKhtLg%3D This is one of the first studies to evaluate neoadjuvant systemic therapy before chemoradiation
-
Chau I, Brown G, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol. 2006;24:668-74. This is one of the first studies to evaluate neoadjuvant systemic therapy before chemoradiation.
-
(2006)
J Clin Oncol
, vol.24
, pp. 668-674
-
-
Chau, I.1
Brown, G.2
Cunningham, D.3
-
29
-
-
77349110719
-
Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: A phase 2 trial
-
20106720 10.1016/S1470-2045(09)70381-X 1:CAS:528:DC%2BC3cXisFGrsbY%3D
-
Chua YJ, Barbachano Y, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol. 2010;11:241-8.
-
(2010)
Lancet Oncol
, vol.11
, pp. 241-248
-
-
Chua, Y.J.1
Barbachano, Y.2
Cunningham, D.3
-
30
-
-
77649209505
-
Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imaging-defined, locally advanced rectal cancer: Grupo cancer de recto 3 study
-
20065174 10.1200/JCO.2009.25.8541 1:CAS:528:DC%2BC3cXksVyrtrc%3D This is the Spanish study evaluating neoadjuvant systemic therapy and restaging prior to preoperative radiation. It demonstrates favorable results for consolidation of systemic therapy and chemoradiation before surgery
-
Fernandez-Martos C, Pericay C, Aparicio J, et al. Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imaging-defined, locally advanced rectal cancer: Grupo cancer de recto 3 study. J Clin Oncol. 2010;28:859-65. This is the Spanish study evaluating neoadjuvant systemic therapy and restaging prior to preoperative radiation. It demonstrates favorable results for consolidation of systemic therapy and chemoradiation before surgery.
-
(2010)
J Clin Oncol
, vol.28
, pp. 859-865
-
-
Fernandez-Martos, C.1
Pericay, C.2
Aparicio, J.3
-
31
-
-
77956662920
-
Neoadjuvant FOLFOX-bev, without radiation, for locally advanced rectal cancer
-
This abstract reports on the single center pilot from Memorial Sloan Kettering selectively omitting chemoradiation for patients with good response to induction FOLFOX ABSTR 3511
-
Schrag D, Weiser MR, Goodman KA, et al. Neoadjuvant FOLFOX-bev, without radiation, for locally advanced rectal cancer. J Clin Oncol. 2010;28(suppl; abstr 3511):15s. This abstract reports on the single center pilot from Memorial Sloan Kettering selectively omitting chemoradiation for patients with good response to induction FOLFOX.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Schrag, D.1
Weiser, M.R.2
Goodman, K.A.3
-
32
-
-
33747075458
-
Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803
-
16822843 10.1200/JCO.2006.06.0863
-
Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol. 2006;24:3535-41.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3535-3541
-
-
Meyerhardt, J.A.1
Heseltine, D.2
Niedzwiecki, D.3
-
33
-
-
77949928737
-
Lifestyle factors and microsatellite instability in colorectal cancer: The evolving field of molecular pathological epidemiology
-
20208016 10.1093/jnci/djq031
-
Ogino S, Stampfer M. Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology. J Natl Cancer Inst. 2010;102:365-7.
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 365-367
-
-
Ogino, S.1
Stampfer, M.2
-
34
-
-
84867817838
-
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
-
23094721 10.1056/NEJMoa1207756 1:CAS:528:DC%2BC38Xhs1Whsr3K
-
Liao X, Lochhead P, Nishihara R, et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med. 2012;367:1596-606.
-
(2012)
N Engl J Med
, vol.367
, pp. 1596-1606
-
-
Liao, X.1
Lochhead, P.2
Nishihara, R.3
-
35
-
-
68849123400
-
Aspirin use and survival after diagnosis of colorectal cancer
-
19671906 10.1001/jama.2009.1112 1:CAS:528:DC%2BD1MXpslynu7w%3D
-
Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA. 2009;302:649-58.
-
(2009)
JAMA
, vol.302
, pp. 649-658
-
-
Chan, A.T.1
Ogino, S.2
Fuchs, C.S.3
-
36
-
-
78650215449
-
Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
-
20970847 10.1016/S0140-6736(10)61543-7 1:CAS:528:DC%2BC3cXhsVGitbfF
-
Rothwell PM, Wilson M, Elwin CE, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 2010;376:1741-50.
-
(2010)
Lancet
, vol.376
, pp. 1741-1750
-
-
Rothwell, P.M.1
Wilson, M.2
Elwin, C.E.3
-
37
-
-
84863399038
-
Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials
-
22440947 10.1016/S0140-6736(12)60209-8 1:CAS:528:DC%2BC38XktlGku7c%3D
-
Rothwell PM, Wilson M, Price JF, et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet. 2012;379:1591-601.
-
(2012)
Lancet
, vol.379
, pp. 1591-1601
-
-
Rothwell, P.M.1
Wilson, M.2
Price, J.F.3
|