Renin inhibition with aliskiren lowers circulating endothelial progenitor cells in patients with early atherosclerosis

Journal of Hypertension

Volumn 31, Issue 3, 2013, Pages 632-635

  Flammer, Andreas J ^a   Gössl, Mario ^a   Li, Jing ^a   Reriani, Martin ^a   Shonyo, Sarah ^a   Loeffler, Darrell ^a   Herrmann, Joerg ^a   Lerman, Lilach O ^a   Lerman, Amir ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALISKIREN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; AMIDE; FUMARIC ACID DERIVATIVE; RENIN;

ADULT; AGED; ANTIHYPERTENSIVE ACTIVITY; ATHEROSCLEROSIS; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG EFFECT; ENDOTHELIAL PROGENITOR CELL; HUMAN; HUMAN CELL; HYPERTENSION; LETTER; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; DRUG ANTAGONISM; ENDOTHELIUM; PATHOLOGY; STEM CELL;

AMIDES; ATHEROSCLEROSIS; ENDOTHELIUM; FUMARATES; HUMANS; RENIN; STEM CELLS;

EID: 84884184229     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32835c6d2d     Document Type: Letter

References (8)

1. Becher UM, Endtmann C, Tiyerili V, Nickenig G, Werner N. Endothelial damage and regeneration: the role of the renin-angiotensin-aldosterone system. Curr Hypertens Rep 2011; 13:86-92.
2. Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, et al. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med 2012; [Epub ahead of print 3 November].
3. Gossl M, Modder UI, Atkinson EJ, Lerman A, Khosla S. Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. J Am Coll Cardiol 2008; 52:1314-1325.
4. Flammer AJ, Martin EA, Gossl M Widmer RJ, Lennon RJ, Sexton JA, et al. Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells. Eur J Nutr 2012. [Epub ahead of print].
5. Bonetti PO, Pumper GM, Higano ST, Holmes DR, Kuvin JT, Lerman A. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol 2004; 44:2137-2141. (Pubitemid 39576032)
6. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005; 353:999-1007. (Pubitemid 41262334)
7. Cherney DZ, Lai V, Scholey JW, Miller JA, Zinman B, Reich HN. Effect of direct renin inhibition on renal hemodynamic function, arterial stiffness, and endothelial function in humans with uncomplicated type 1 diabetes: a pilot study. Diabetes Care 2010; 33:361-365.
8. Virdis A, Ghiadoni L, Qasem AA, Lorenzini G, Duranti E, Cartoni G, et al. Effect of aliskiren treatment on endothelium-dependent vasodilation and aortic stiffness in essential hypertensive patients. Eur Heart J 2012; 33:1530-1538.