Downregulation of CD24 inhibits invasive growth, facilitates apoptosis and enhances chemosensitivity in gastric cancer AGS cells

European Review for Medical and Pharmacological Sciences

Volumn 17, Issue 13, 2013, Pages 1709-1715

  Jiao, X L ^a   Zhao, C ^a   Niu, M ^a   Chen, D ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Apoptosis; CD24; Chemosensitivity; Gastric cancer; Invasion

Indexed keywords

CD24 ANTIGEN; DOXORUBICIN; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER RESISTANCE; CELL MIGRATION; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; SOLID TUMOR; STOMACH CANCER; TUMOR INVASION; ANIMAL; BIOSYNTHESIS; CELL MOTION; DOWN REGULATION; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; GENETICS; NICK END LABELING; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, CD24; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HUMANS; IN SITU NICK-END LABELING; INDICATORS AND REAGENTS; MICE; NEOPLASM INVASIVENESS; RNA, SMALL INTERFERING; STOMACH NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84884179476     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. PARKIN DM. International variation. Oncogene 2004, 23:6329-6340
2. GRIMELIUS B, EKSTROM K, HOFFMAN K, GRAF W, SJODEN PO, HAGLUND U, SVENSSON C, ENANDER LK, LINNE T, SELLSTROM H. Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer. Ann Oncol 1997; 8: 163-168.
3. YANG XR, XU Y, YU B, ZHOU J, LI JC, QIU SJ, SHI YH, WANG XY, DAI Z, SHI GM, WU B, WU LM, YANG GH, ZHANG BH, QIN WX, FAN J. CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery. Clin Cancer Res 2009; 15: 5518-5527.
4. CHOI YL, LEE SH, KWON GY, PARK CK, HAN JJ, CHOI JS, CHOI HY, KIM SH, SHIN YK.Overexpression of CD24: association with invasiveness in urothelial carcinoma of the bladder. Arch Pathol Lab Med 2007; 131: 275-281.
5. MILLER E, SHAPIRA S, GUR E, NAUMOV I, KAZANOV D, LESHEM D, BARNEA Y, MESHIACH Y, GAT A, SION D, ARBER N, KRAUS S. Increased expression of CD24 in nonmelanoma skin cancer. Int J Biol Markers 2012; 27: e331-336
6. DENG J, GAO G, WANG L, WANG T, YU J, ZHAO Z. CD24 expression as a marker for predicting clinical outcome in human gliomas.J Biomed Biotechnol 2012; 2012: 517172.
7. SAGIV E,MEMEO L,KARIN A,KAZANOV D,JACOBHIRSCH J,MANSUKHANI M,RECHAVI G,HIBSHOOSH H,ARBER N. CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis.Gastroenterology 2006:131, 630-639
8. SU D, DENG H, ZHAO X, ZHANG X, CHEN L, CHEN X, LI Z, BAI Y, WANG Y, ZHONG Q, YI T, QIAN Z, WEI Y. Targeting CD24 for treatment of ovarian cancer by short hairpin RNA. Cytotherapy 2009; 11: 642-652.
9. SAGIV E, STARR A, ROZOVSKI U, KHOSRAVI R, ALTEVOGT P, WANG T, ARBER N. Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA. Cancer Res 2008; 68: 2803-2812.
10. SALNIKOV AV, BRETZ NP, PERNE C, HAZIN J, KELLER S, FOGEL M, HERR I, SCHLANGE T, MOLDENHAUER G, ALTEVOGT P. Antibody targeting of CD24 efficiently retards growth and influences cytokine milieu in experimental carcinomas. Br J Cancer 2013; 108: 1449-1459.
11. TAKAHASHI M, NAKAJIMA M, OGATA H, DOMEKI Y, OHTSUKA K, IHARA K, KURAYAMA E, YAMAGUCHI S, SASAKI K, MIYACHI K, KATO H. CD24 Expression is associated with progression of gastric cancer. Hepatogastroenterology 2012; 60(124).