Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2012, Pages 6764-6767

  Kishi, T ^a   Sunagawa, K ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN-DERIVED NEUROTROPHIC FACTORS; CALORIE RESTRICTION; COGNITIVE DECLINE; COGNITIVE FUNCTIONS; EXERCISE TRAINING; MORRIS WATER MAZE; SPONTANEOUSLY HYPERTENSIVE RATS; UP-REGULATION;

ENGINEERING; INDUSTRIAL ENGINEERING;

RATS;

BRAIN DERIVED NEUROTROPHIC FACTOR;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; CALORIC RESTRICTION; CEREBROVASCULAR ACCIDENT; COGNITION; COGNITIVE DEFECT; DISEASE MODEL; FOOD DEPRIVATION; HIPPOCAMPUS; HYPERTENSION; MALE; MAZE TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STATISTICAL MODEL; UPREGULATION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALORIC RESTRICTION; COGNITION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; FOOD DEPRIVATION; HIPPOCAMPUS; HYPERTENSION; MALE; MAZE LEARNING; MODELS, STATISTICAL; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED SHR; STROKE; UP-REGULATION;

EID: 84884177468     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/EMBC.2012.6347547     Document Type: Conference Paper

References (26)

1. Berr C, Balansard B, Arnaud J, Roussel AM, Alperovitch A, "Cognitive decline is associated with systemic oxidative stress: the E VA study. Etude du Vieillissement Arterial," J Am Geriatr Soc, 2000, vol. 48, pp. 1285-1291.
2. Sato H, Takahashi T, Sumitani K, Takatsu H, Urano S, "Glucocorticoid generates ROS to induce oxidative injury in the hippocampus, leading to impairment of cognitive function of rats," J Clin Biochem Nutr, 2010, vol. 47, pp. 224-232.
3. Mancias M, Dwornik A, Ziemlinska E, Fehr S, Schachner M, Czarkowska-Bauch J, Skup M, "Locomotor exercise alters expression of pro-brain-derived neurotrophic factor, brain-derived neurotrophic factor and its receptor TrkB in the spinal cord of adult rats," Eur J Neurosci, 2007, vol. 25, pp. 2425-2444.
4. Zacchigna S, Lambrechts D, Carmeliet P, "Neurovascular signaling defects in neurodegeneration. Nat Rev, 2008, vol. 9, pp. 169-181.
5. Lee TH, Yang JT, Kato H, Wu JH, "Hypertension downregulates the expression of brain-derived neurotrophic factor in the ischemic-vulnerable hippocampal CA1 and cortical areas after carotid artery occlusion," Brain Res, 2006, vol. 1116, pp. 31-38.
6. Beck T, Lindholm D, Castren E, Wree A, "Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus," J Cereb Blood Flow Metab, 1994, vol. 14, pp. 689-692.
7. Liu YF, Chen HI, Wu CL, Kuo YM, Yu L, Juang AM, Wu FS, Chuang JI, Jen CJ, "Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I," J Physiol, 2009, vol. 586, pp. 3221-3231.
8. Kim H, Heo HI, Kim DH, Ko IG, Lee SS, Kim SE, Kim TW, Ji ES, Kim JD, Shin MS, Choi YW, Kim CJ, "Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneously hypertensive rats," Neurosci Lett, 2011, vol. 504, pp. 35-39.
9. Gomez-Pinilla F, Vaynman S, Ying Z, "Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition," Eur J Neurosci, 2008, vol. 28, pp. 2278-2287.
10. Wu P, Shen Q, Dong S, Xu Z, Tsien JZ, Hu Y, "Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice," Neurobiol Aging, 2008, vol. 29, pp.1502-1511.
11. Yilmaz N, Vural H, Yilmaz M, Sutcu R, Sirmali R, Hicyilmaz H, Delibas N, "Calorie restriction modulates hippocampal NMDA receptors in diet-induced obese rats," J Recept Signal Transduct Res, 2011, vol. 31, pp. 214-219.
12. Martin CK, Anton SD, han H, York-Crowe E, Redman LM, Ravussin E, Williamson DA, "Examination of cognitive function during six months of calorie restriction: results of a randomized controlled study," Rejuvenation Res, 2007, vol. 10, pp. 179-190.
13. Kimura S, Saito H, Minami M, Togashi H, Nakamura N, Nemoto M, Parvez HS, "Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats," Toxicology, 2000, vol. 153, pp. 167-178.
14. 1 receptor in the rostral ventrolateral medulla of hypertensive rats," Clin Exp Hypertens, to be published.
15. Kishi T, Hirooka Y, Ogawa K, Konno S, Sunagawa K, "Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats," Clin Exp Hypertens, 2011, vol. 33, pp. 245-250.
16. Morris R, "Development of a water-maze procedure for studying spatial learning in the rat," J Neurosci Methods, 1984, vol. 11, pp. 47-60.
17. Chan SH, Wu CW, Chang AY, Hsu KS, Chan J Y, "Transcriptional upregulation of brain-derived neurotrophic factor in rostral ventrolateral medulla by angiotensin II: significant in superoxide homeostasis and neural regulation of arterial pressure," Circ Res, 2010, vol. 107, pp. 1127-1139.
18. Kishi T, Hirooka Y, Konno S, Ogawa K, Sunagawa K, "Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase-extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats," Hypertension, 2010, vol. 55, pp. 291-297.
19. Mousa TM, Liu D, Cornish KG, Zucker IH, "Exercise training enhances baroreflex sensitivity by an angiotensin II-dependent mechanism in chronic heart failure," J Appl Physiol, 2008, vol. 104, pp. 616-624.
20. Kar S, Gao L, Zucker IH, "Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure," J Appl Physiol, 2010, vol. 108, pp. 923-932.
21. Felix JVC, Michelini LC, "Training-induced pressure fall in spontaneously hypertensive rats is associated with reduced angiotensinogen mRNA expression within the nucleus tractus solitarii," Hypertension, 2007, vol. 50, pp. 780-785.
22. Chennaoui M, Drogou C, Gomez-Merino D, "Effects of physical training on IL-1β, IL-6 and IL-1ra concentrations in various brain areas of the rat," Eur Cytokine Netw, 2008, vol. 19, pp. 8-14.
23. Francis J, Chu Y, Johnson AK, Weiss RM, Felder RB, "Acute myocardial infarction induces hypothalamic cytokine synthesis," Am J Physiol, 2004, vol. 286, pp. H2264-H2271.
24. Ferguson AV, Washburn DL, "Angiotensin II: a peptidergic neurotransmitter in central autonomic pathways," Prog Neurobiol, 1998, vol. 54, pp. 169-192.
25. Moser MB, Trommald M, Andersen P, "An Increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses," Proc Natl Acad Sci U S A, 1994, vol. 91, pp. 12673-12675.
26. McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, Wilson MA, "Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice," Cell, 1996, vol. 87, pp. 1339-1349.