Anti-thymocyte globulins for post-transplant graft-versus-host disease prophylaxis-A systematic review and meta-analysis

Critical Reviews in Oncology/Hematology

Volumn 88, Issue 1, 2013, Pages 178-186

  Theurich, Sebastian ^a   Fischmann, Hans ^a   Chakupurakal, Geothy ^a   Shimabukuro Vornhagen, Alexander ^a   Chemnitz, Jens M ^a   Holtick, Udo ^a   Rothe, Achim ^a   Scheid, Christof ^a   Hallek, Michael ^a   Skoetz, Nicole ^a   von Bergwelt Baildon, Michael ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Allogeneic stem cell transplantation; Anti thymocyte globulins; ATG; Bone marrow transplantation; Graft versus host disease; GvHD; Meta analysis; Systematic review

Indexed keywords

THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; CHRONIC GRAFT VERSUS HOST DISEASE; DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; GRAFT VERSUS HOST REACTION; HUMAN; INCIDENCE; META ANALYSIS; NONHUMAN; OVERALL SURVIVAL; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RELAPSE; REVIEW; SURVIVAL RATE; SYSTEMATIC REVIEW;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANTI-THYMOCYTE GLOBULINS; ATG; BONE MARROW TRANSPLANTATION; GRAFT-VERSUS-HOST DISEASE; GVHD; META-ANALYSIS; SYSTEMATIC REVIEW;

ANTILYMPHOCYTE SERUM; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; ODDS RATIO; PREMEDICATION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 84884146092     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2013.03.009     Document Type: Review

References (19)

1. Ferrara J.L.M., Levine J.E., Reddy P., et al. Graft-versus-host disease. Lancet 2009, 373(9674):1550-1561.
2. Nash R.A., Antin J.H., Karanes C., et al. Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. Blood 2000, 96(6):2062-2068.
3. Grüllich C., Ziegler C., Finke J. Rabbit anti T-lymphocyte globulin induces apoptosis in peripheral blood mononuclear cell compartments and leukemia cells, while hematopoetic stem cells are apoptosis resistant. Biology of Blood and Marrow Transplantation 2009, 15(2):173-182.
4. Bacigalupo A. Antilymphocyte/thymocyte globulin for graft versus host disease prophylaxis: efficacy and side effects. Bone Marrow Transplantation 2005, 35(3):225-231.
5. Moher D., Liberati A., Tetzlaff J., et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Journal of Clinical Epidemiology 2009, 62(10):1006-1012.
6. Parmar M.K., Torri V., Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine 1998, 17(24):2815-2834.
7. Tierney J.F., Stewart L.A., Ghersi D., et al. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 2007, 8:16.
8. Bacigalupo A., Lamparelli T., Bruzzi P., et al. Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO). Blood 2001, 98(10):2942-2947.
9. Bacigalupo A., Lamparelli T., Gualandi F., et al. Prophylactic antithymocyte globulin reduces the risk of chronic graft-versus-host disease in alternative-donor bone marrow transplants. Biology of Blood and Marrow Transplantation 2002, 8(12):656-661.
10. Champlin R.E., Perez W.S., Passweg J.R., et al. Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens. Blood 2007, 109(10):4582-4585.
11. Finke J., Bethge W.A., Schmoor C., et al. Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial. Lancet Oncology 2009, 10(9):855-864.
12. Doney K.C., Weiden P.L., Storb R., et al. Failure of early administration of antithymocyte globulin to lessen graft-versus-host disease in human allogeneic marrow transplant recipients. Transplantation 1981, 31(2):141-143.
13. Weiden P.L., Doney K., Storb R., et al. Antihuman thymocyte globulin for prophylaxis of graft-versus-host disease. A randomized trial in patients with leukemia treated with HLA-identical sibling marrow grafts. Transplantation 1979, 27(4):227-230.
14. Bacigalupo A., Lamparelli T., Barisione G., et al. Thymoglobulin prevents chronic graft-versus-host disease, chronic lung dysfunction, and late transplant-related mortality: long-term follow-up of a randomized trial in patients undergoing unrelated donor transplantation. Biology of Blood and Marrow Transplantation 2006, 12(5):560-565.
15. Waller E.K., Langston A.A., Lonial S., et al. Pharmacokinetics and pharmacodynamics of anti-thymocyte globulin in recipients of partially HLA-matched blood hematopoietic progenitor cell transplantation. Biology of Blood and Marrow Transplantation 2003, 9(7):460-471.
16. Socié G., Schmoor C., Bethge W.A., et al. Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius. Blood 2011, 117(23):6375-6382.
17. Scheinberg P., Nunez O., Weinstein B., et al. Horse versus rabbit antithymocyte globulin in acquired aplastic anemia. New England Journal of Medicine 2011, 365(5):430-438.
18. Kumar A., Mhaskar A.R., Reljic T., et al. Antithymocyte globulin for acute-graft-versus-host-disease prophylaxis in patients undergoing allogeneic hematopoietic cell transplantation: a systematic review. Leukemia 2011, 2011. 349. [Epub ahead of print].
19. Ramsay N.K., Kersey J.H., Robison L.L., et al. A randomized study of the prevention of acute graft-versus-host disease. New England Journal of Medicine 1982, 306(7):392-397.