A permeation method for detection of self-aggregation of doxorubicin in aqueous environment

International Journal of Pharmaceutics

Volumn 454, Issue 1, 2013, Pages 559-561

  Fülöp, Zoltán ^a   Gref, Ruxandra ^b   Loftsson, Thorsteinn ^a  

^a UNIVERSITY OF ICELAND   (Iceland)

^b UNIV PARIS SUD   (France)

Author keywords

Aggregation; Doxorubicin; Permeation; Self association

Indexed keywords

DIMER; DOXORUBICIN; OLIGOSACCHARIDE;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DRUG DETERMINATION; PH; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84884144891     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.06.058     Document Type: Article

References (18)

1. Anand, R., Ottani, S., Manoli, F., Manet, I., Monti, S., 2012. A close-up on doxorubicin binding to γ-cyclodextrin: an elucidating spectroscopic, photophysical and conformational study. RSC Adv. 2, 2346-2357.
2. Beijnen, J.H., van der Houwen, O.A.G.J., Underberg, W.J.M., 1986. Aspects of the degradation kinetics of doxorubicin in aqueous solution. Int. J. Pharm. 32, 123-131. (Pubitemid 16015291)
3. Beshnova, D.O., Lantushenko, A.O., Evstigneev, M.P., 2009. Analysis of the dependence of the constant of self association of aromatic molecules on the length of an aggregate. Ukranian J. Phys. 54, 355-360.
4. Brewster, M.E., Loftsson, T., Estes, K.S., Lin, J.-L., Fridriksdóttir, H., Bodor, N., 1992. Effect of various cyclodextrins on solution stability and dissolution rate of doxorubicin hydrochloride. Int. J. Pharm. 79, 289-299.
5. Fülöp, Z., Kurkov, S.V., Nielsen, T.T., Larsen, K.L., Loftsson, T., 2012. Self-assembly of cyclodextrins: formation of cyclodextrin polymer based nanoparticles. J. Drug Deliv. Sci. Technol. 22, 215-222.
6. Hayakawa, E., Furuya, K., Kuroda, T., Moriyama, M., Kondo, A., 1991a. Viscosity study on the self-association of doxorubicin in aqueous solution. Chem. Pharm. Bull. 39, 1282-1286.
7. Hayakawa, E., Furuya, K., Ueno, H., Kuroda, T., Moriyama, M., Kondo, A., 1991b. Visible absorption and proton nuclear magnetic resonance studies on the self-association of doxorubicin in aqueous solution. Chem. Pharm. Bull. 39, 1009-1012.
8. Loftsson, T., 2010. Aqueous solubility and true solutions. Pharmazie 65, 404-407.
9. Loftsson, T., Brewster, M.E., 2008. Physicochemical properties of water and its effect on drug delivery. A commentary. Int. J. Pharm. 354, 248-254. (Pubitemid 351410449)
10. Loftsson, T., Magnúsdóttir, A., Másson, M., Sigurjónsdóttir, J.F., 2002. Self-association and cyclodextrin solubilization of drugs. J. Pharm. Sci. 91, 2307-2316. (Pubitemid 35231194)
11. Menozzi, M., Valentini, L., Vannini, E., Arcamone, F., 1984. Self-association of doxorubicin and related compounds in aqueous solution. J. Pharm. Sci. 73, 766-770. (Pubitemid 14122790)
12. Messner, M., Kurkov, S.V., Brewster, M.E., Jansook, P., Loftsson, T., 2011a. Self-assembly of cyclodextrin complexes: aggregation of hydrocortisone/cyclodextrin complexes. Int. J. Pharm. 407, 174-183.
13. Messner, M., Kurkov, S.V., Flavià-Piera, R., Brewster, M.E., Loftsson, T., 2011b. Self-assembly of cyclodextrins: the effect of the guest molecule. Int. J. Pharm. 408, 235-247.
14. Nawara, K., Krysinski, P., Blanchard, G.J., 2012. Photoinduced reactivity of doxorubicin: catalysis and degradation. J. Phys. Chem. A 116, 4330-4337.
15. Razzano, G., Rizzo, V., Vigevani, A., 1990. Determination of phenolic ionization constants of anthracyclines with modified substitution pattern of anthraquinone chromophore. Farmaco 45, 215-222. (Pubitemid 20172263)
16. Schreier, S., Malheiros, S.V., de Paula, E., 2000. Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects. Biochim. Biophys. Acta 1508, 210-234.
17. Strekal, N., German, A., Gachko, G., Maskevich, A., Maskevich, S., 2001. The study of the doxorubicin adsorbed onto chemically modified silver films by surface-enhanced spectroscopy. J. Mol. Struct. 563-564, 183-191. (Pubitemid 32952834)
18. Wu, D.C., Ofner, C.M., 2012. Adsorption and degradation of doxorubicin from aqueous solution in polypropylene containers. AAPS PharmScitech 14, 74-77.