Plasma triglyceride/HDL-cholesterol ratio, insulin resistance, and cardiometabolic risk in young adults

Journal of Lipid Research

Volumn 54, Issue 10, 2013, Pages 2795-2799

  Murguía Romero, Miguel ^a   Jiménez Flores, J Rafael ^a   Sigrist Flores, Santiago C ^a   Espinoza Camacho, Miguel A ^a   Jiménez Morales, Mayra ^a   Piña, Enrique ^b   Méndez Cruz, A René ^a   Villalobos Molina, Rafael ^a   Reaven, Gerald M ^c  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Metabolic syndrome; Triglyceride high density lipoprotein cholesterol; Young Mexicans

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTICLE; CARDIOMETABOLIC RISK; COLLEGE STUDENT; FEMALE; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MEXICO; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL;

METABOLIC SYNDROME; TRIGLYCERIDE/HIGH DENSITY LIPOPROTEIN CHOLESTEROL; YOUNG MEXICANS;

ADOLESCENT; CHOLESTEROL, HDL; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; PREVALENCE; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SEX DISTRIBUTION; TRIGLYCERIDES; VASCULAR STIFFNESS; YOUNG ADULT;

EID: 84884133917     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M040584     Document Type: Article

References (19)

1. McLaughlin, T., G. Reaven, F. Abbasi, C. Lamendola, M. Saad, D. Waters, J. Simon, and R. M. Krauss. 2005. Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease? Am. J. Cardiol. 96: 399-404.
2. Salazar, M. R., H. A. Carbajal, W. G. Espeche, C. A. Dulbecco, M. Aizpurúa, A. G. Marillet, R. F. Echeverría, and G. M. Reaven. 2011. Relationships among insulin resistance, obesity, diagnosis of the metabolic syndrome and cardio-metabolic risk. Diab. Vasc. Dis. Res. 8: 109-116.
3. Sumner, A. E., K. B. Finley, D. J. Genovese, M. H. Criqui, and R. C. Boston. 2005. Fasting triglyceride and the triglyceride-HDL cholesterol ratios are not markers of insulin resistance in African Americans. Arch. Intern. Med. 165: 1395-1400.
4. Bovet, P., D. Faeh, A. Gabriel, and L. Tappy. 2006. The prediction of insulin resistance with serum triglyceride and high-density lipoprotein cholesterol levels in an East African population. Arch. Intern. Med. 166: 1236-1237.
5. Sumner, A. E., J. L. Harman, S. G. Buxbaum, B. V. Miller 3rd, A. V. Tambay, S. B. Wyatt, H. A. Taylor, C. N. Rotimi, and D. F. Sarpong. 2010. The triglyceride/high-density lipoprotein cholesterol ratio fails to predict insulin resistance in African-American women: an analysis of Jackson Heart Study. Metab. Syndr. Relat. Disord. 8: 511-514.
6. Kim-Dorner, S. J., P. A. Deuster, S. A. Zeno, A. T. Remaley, and M. Poth. 2010. Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance? Metabolism. 59: 299-304.
7. Li, C., E. S. Ford, Y. X. Meng, A. H. Mokdad, and G. M. Reaven. 2008. Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity? Cardiovasc. Diabetol. 7: 4.
8. Alberti, K. G., R. H. Eckel, S. M. Grundy, P. Z. Zimmet, J. I. Cleeman, K. A. Donato, J. C. Fruchart, W. P. James, C. M. Loria, S. C. Smith, Jr ., et al. 2009. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Circulation. 120: 1640-1645.
9. Urbina, E. M., P. R. Khoury, C. E. McCoy, L. M. Dolan, S. R. Daniels, and T. R. Kimball. 2013. Triglyceride to HDL-C ratio and increased arterial stiffness in children, adolescents, and young adults. Pediatrics. 131: e1082 - e1090.
10. Jiménez-Flores, J. R., M. Murguía-Romero, M. I. Mendoza-Ramos, S. Sigrist-Flores, N. Y. Rodríguez-Soriano, L. I. Ramírez-García, R. Jesús-Sandoval, M. A. Álvarez-Gasca, E. Orozco, R. Villalobos- Molina, et al. 2012. Metabolic syndrome occurrence in university students from México City: the binomium low HDL/waist circumference is the major prevalence factor. Open J. Prev. Med. 2: 177-182.
11. Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner. 1985. Homeostasis model assessment: insulin resistance and -cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28: 412-419.
12. Katz, A., S. S. Nambi, K. Mather, A. D. Baron, D. A. Follmann, G. Sullivan, and M. J. Quon. 2000. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab. 85: 2402-2410.
13. Zavaroni, I., L. Bonini, P. Gasparini, A. L. Barilli, A. Zuccarelli, E. Dall'Aglio, R. Delsignore, and G. M. Reaven. 1999. Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: the Barilla factory revisited. Metabolism. 48: 989-994.
14. Akobeng, A. K. 2007. Understanding diagnostic tests 1: sensitivity, specificity and predictive values. Acta Paediatr. 96: 338-341.
15. Salazar, M. R., H. A. Carbajal, W. G. Espeche, C. E. Leiva Sisnieguez, E. Balbín, C. A. Dulbecco, M. Aizpurúa, A. G. Marillet, and G. M. Reaven. 2012. Relation among the plasma triglyceride/high-density lipoprotein cholesterol concentration ratio, insulin resistance, and associated cardio-metabolic risk factors in men and women. Am. J. Cardiol. 109: 1749-1753.
16. R Development Core Team. 2011. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. (http://www.R-project.org).
17. Giannini, C., N. Santoro, S. Caprio, G. Kim, D. Lartaud, M. Shaw, B. Pierpont, and R. Weiss. 2011. The triglyceride-to-HDL cholesterol ratio. Association with insulin resistance in obese youths of different ethnic backgrounds. Diabetes Care. 34: 1869-1874.
18. Cheal, K. L., F. Abbasi, C. Lamendola, T. McLaughlin, G. M. Reaven, and E. S. Ford. 2004. Relationship to insulin resistance of the adult treatment panel III diagnostic criteria for identification of the metabolic syndrome. Diabetes. 53: 1195-1200.
19. Sierra-Johnson, J., B. D. Johnson, T. G. Allison, K. R. Bailey, G. L. Schwartz, and S. T. Turner. 2006. Correspondence between the adult treatment panel III criteria for metabolic syndrome and insulin resistance. Diabetes Care. 29: 668-672.