Regulation of multidrug resistance protein 2 (MRP2, ABCC2) expression by statins: Involvement of SREBP-mediated gene regulation

International Journal of Pharmaceutics

Volumn 452, Issue 1-2, 2013, Pages 36-41

  Kobayashi, Masaki ^a   Gouda, Keisuke ^a   Chisaki, Ikumi ^a   Asada, Koji ^a   Ogura, Jiro ^a   Takahashi, Natsuko ^b   Konishi, Toru ^a   Koshida, Yusuke ^a   Sasaki, Shotaro ^a   Yamaguchi, Hiroaki ^a   Iseki, Ken ^a,c  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^c HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Hepatocytes; Multidrug resistance protein 2; Statin; Sterol regulatory element binding protein

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIVER X RECEPTOR; MULTIDRUG RESISTANCE PROTEIN 2; PITAVASTATIN; PRAVASTATIN; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; CYTOSOL; GENE CONTROL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 84884131005     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.04.019     Document Type: Article

References (26)

1. Argmann, C.A., Edwards, J.Y., Sawyez, C.G., O'Neil, C.H., Hegele, R.A., Pickering, J.G., Huff, M.W., 2005. Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux. J. Biol. Chem. 280, 22212-22221. (Pubitemid 40827878)
2. Brown, M.S., Goldstein, J.L., 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89,331-340. (Pubitemid 27220877)
3. Chisaki, I., Kobayashi, M., Itagaki, S., Hirano, T., Iseki, K., 2009. Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. Biochim. Biophys. Acta 1788, 2396-2403.
4. Cui, Y., Konig, J., Leier, I., Buchholz, U., Keppler, D., 2001. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J. Biol. Chem. 276, 9626-9630.
5. Goldstein, J.L., Brown, M.S., 1990. Regulation of the mevalonate pathway. Nature 343, 425-430.
6. Hagenbuch, B., Meier, P.J., 2004. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily new nomenclature and molecular/functional properties. Pflugers Arch. 447,653-665. (Pubitemid 38241451)
7. Havel, R.J., Rapaport, E., 1995. Management of primary hyperlipidemia. N. Engl. J. Med. 332, 1491-1498.
8. Hayashi, H., Mizuno, T., Horikawa, R., Nagasaka, H., Yabuki, T., Takikawa, H., Sugiyama, Y., 2012. 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration. J. Hepatol. 56, 1136-1144.
9. Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T., Sugiyama, Y., 1997. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol. 272, G16-G22.
10. Johnson, B.M., Zhang, P., Schuetz, J.D., Brouwer, K.L., 2006. Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats. Drug Metab. Dispos. 34, 556-562.
11. Kartenbeck, J., Leuschner, U., Mayer, R., Keppler, D., 1996. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 23, 1061-1066.
12. Kim, R.B., 2002. Transporters and xenobiotic disposition. Toxicology 181/182, 291-297. (Pubitemid 36015716)
13. Kobayashi, M., Otsuka, Y., Itagaki, S., Hirano, T., Iseki, K., 2006. Inhibitory effects of statins on human monocarboxylate transporter 4. Int. J. Pharm. 317, 19-25. (Pubitemid 43866340)
14. Kobayashi, M., Chisaki, I., Narumi, K., Hidaka, K., Kagawa, T., Itagaki, S., Hirano, T., Iseki, K., 2008a. Association between risk of myopathy and cholesterol-lowering effect: a comparison of all statins. Life Sci. 82, 969-975.
15. Kobayashi, M., Kagawa, T., Narumi, K., Itagaki, S., Hirano, T., Iseki, K., 2008b. Bicar-bonate supplementation as a preventive way in statins-induced muscle damage. J. Pharm. Pharm. Sci. 11, 1-8.
16. Kobayashi, M., Gouda, K., Chisaki, I., Ochiai, M., Itagaki, S., Iseki, K., 2011. Regulation mechanism of ABCA1 expression by statins in hepatocytes. Eur. J. Pharmacol. 662, 9-14.
17. Kullak-Ublick, G.A., Stieger, B., Meier, P.J., 2004. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126, 322-342. (Pubitemid 38040747)
18. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
19. Matsushima, S., Maeda, K., Kondo, C., Hirano, M., Sasaki, M., Suzuki, H., Sugiyama, Y., 2005. Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2 OATP1B1/multidrug resistance 1, and OATP1B1/breastcancer resistance protein. J. Pharmacol. Exp. Ther. 314, 1059-1067. (Pubitemid 41205969)
20. Miyata, K.S., McCaw, S.E., Patel, H.V., Rachubinski, R.A., Capone, J.P., 1996. The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling. J. Biol. Chem. 271, 9189-9192. (Pubitemid 26137316)
21. Paulusma, C.C., Oude Elferink, R.P., 1997. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man. J. Mol. Med. 75, 420-428. (Pubitemid 27297012)
22. Paulusma, C.C., Bosma, P.J., Zaman, G.J., Bakker, C.T., Otter, M., Scheffer, G.L., Scheper, R.J., Borst, P., Oude Elferink, R.P., 1996. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 271, 1126-1128. (Pubitemid 26075228)
23. Repa, J.J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J.M., Shimomura, I., Shan, B., Brown, M.S., Goldstein, J.L., Mangelsdorf, D.J., 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 14, 2819-2830.
24. Sasaki, M., Suzuki, H., Ito, K., Abe, T., Sugiyama, Y., 2002. Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2(MRP2/ABCC2). J. Biol. Chem. 277, 6497-6503. (Pubitemid 34968447)
25. Shinar, D.M., Endo, N., Rutledge, S.J., Vogel, R., Rodan, G.A., Schmidt, A., 1994. NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene 147, 273-276. (Pubitemid 24306344)
26. Willy, P.J., Umesono, K., Ong, E.S., Evans, R.M., Heyman, R.A., Mangelsdorf, D.J., 1995. LXR a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9, 1033-1045.