Drops of madness? Recreational misuse of tropicamide collyrium; early warning alerts from Russia and Italy

General Hospital Psychiatry

Volumn 35, Issue 5, 2013, Pages 571-573

  Bersani, Francesco Saverio ^a,b   Corazza, Ornella ^a,c   Simonato, Pierluigi ^a   Mylokosta, Anna ^d   Levari, Ermelinda ^e   Lovaste, Raffaele ^e   Schifano, Fabrizio ^a  

^a UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF SZCZECIN   (Poland)

^e Addiction Unit (Sert Servizio Tossicodipendenze)   (Italy)

Author keywords

Internet monitoring; Online pharmacies; Prescription drugs; Public health; Recreational use; ReDNet Project; Tropicamide

Indexed keywords

CANNABIS; OPIATE; PSYCHOTROPIC AGENT; TROPICAMIDE;

ABNORMAL DREAMING; ALCOHOL CONSUMPTION; ARTICLE; CONVULSION; DRUG MISUSE; DYSPHORIA; EUROPEAN UNION; HALLUCINATION; HEADACHE; HUMAN; HYPERTHERMIA; INTERNET; INTRAVENOUS DRUG ABUSE; ITALY; KIDNEY PAIN; MEDLINE; MYDRIASIS; ONLINE SYSTEM; PSYCINFO; RESTLESSNESS; RUSSIAN FEDERATION; SLURRED SPEECH; SUICIDAL BEHAVIOR; TACHYCARDIA; TREMOR; TREND STUDY; UNCONSCIOUSNESS;

INTERNET MONITORING; ONLINE PHARMACIES; PRESCRIPTION DRUGS; PUBLIC HEALTH; RECREATIONAL USE; REDNET PROJECT; TROPICAMIDE;

HUMANS; ITALY; MUSCARINIC ANTAGONISTS; RUSSIA; STREET DRUGS; SUBSTANCE ABUSE, INTRAVENOUS; TROPICAMIDE;

EID: 84884127339     PISSN: 01638343     EISSN: 18737714     Source Type: Journal    
DOI: 10.1016/j.genhosppsych.2013.04.013     Document Type: Article

References (21)

1. Schifano F., Leoni M., Martinotti G., et al. Importance of cyberspace for the assessment of the drug abuse market: preliminary results from the Psychonaut 2002 Project. Cyber Psychol Behavior 2003, 6:405-441.
2. Corazza O., Assi S., Simonato P., et al. Promoting innovation and excellence to face the rapid diffusion of novel psychoactive substances (NPS) in the EU: the outcomes of the ReDNet project. Hum Psychopharmacol 2013, in press.
3. Portes A.J., Barbosa A.C., de Mello G.L., et al. Tropicamide 1% mydriatic effect: comparison between spray in closed eyes and eye drops in open eyes. J Ocul Pharmacol Ther 2012, 28:632-635.
4. http://www.bluelight.ru/vb/threads/590423-Tropicamide-abuse-in-Russia.
5. "The Independent", 21 August 2011. http://www.independent.co.uk/news/world/europe/the-squalid-lonely-death-of-ivan-kanev-2341191.html.
6. Schifano F., Marra R., Magni G. Orphenadrine abuse. South Med J 1988, 81(4):546-547.
7. Dose M., Tempel H.D. Abuse potential of anticholinergics. Pharmacopsychiatry 2000, 33(Suppl 1):43-46.
8. Italian Department of Anti-Drug Politics, 2013;. http://www.allertadroga.it/sapd/login/.
9. http://www.bluelight.ru/vb/threads/617629-Tropicamide-Safe-solution-percentage.
10. "The Independent", 22 June 2011. http://www.independent.co.uk/news/world/europe/krokodil-the-drug-that-eats-junkies-2300787.html.
11. "Opposing Views", 28 June 2011. http://www.opposingviews.com/i/deadly-russian-street-drug-krokodil-rots-skin-damages-brain.
12. http://www.google.it/trends/explore#q=tropicamide.
13. https://www.medstoreinternational.com/buy-Mydriacyl.php.
14. Betz A.J., McLaughlin P.J., Burgos M., et al. The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of Parkinsonian tremor: possible role of M4 receptors. Psychopharmacology (Berl) 2007, 194:347-359.
15. Zemishlaney Z., Aizenberg D., Weiner Z., et al. Trihexyphenidyl (Artane) abuse in schizophrenic patients. Int Clin Psychopharmacol 1996, 11:199-202.
16. Schifano F., di Costanzo E. Excessive use of anticholinergic drugs in a sub-sample of Italian schizophrenics. Int J Clin Pharmacol Ther Toxicol 1991, 29(5):184-186.
17. Sato E.H., de Freitas D., Foster C.S. Abuse of cyclopentolate hydrochloride (Cyclogyl) drops. N Engl J Med 1992, 326(20):1363-1364.
18. Patsiopoulos G., Lam V., Lake S., Koevary S.B. Insulin and tropicamide accumulate in the contralateral, untreated eye of rats following ipsilateral topical administration by a mechanism that does not involve systemic uptake. Optometry 2003, 74(4):226-232.
19. http://nurris.livejournal.com/2078.html.
20. Munhoz R.P., Moscovich M.M., Filla L., et al. Topical tropicamide induced delirium and psychosis: case report. J Bras Psiquiatr 2010, 59:74-76.
21. http://www.forchem.narod.ru/Tropicamide2011.pdf.