Phenotype sequencing: High-throughput discovery of the genetic causes of a phenotype

Microbe

Volumn 8, Issue 8, 2013, Pages 321-327

  Lee, Christopher ^a   Harper, Marc ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLAMYDIA;

EID: 84883893338     PISSN: 15587452     EISSN: 15587460     Source Type: Journal    
DOI: 10.1128/microbe.8.321.1     Document Type: Article

References (7)

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2. Bochner, B. R., P. Gadzinski, and E. Panomitros. 2001. Phenotype microarrays for high-throughput phenotypic testing and assay of gene function. Genome Res. 11:1246-1255.
3. Christen, B., E. Abeliuk, J. M. Collier, V. S. Kalogeraki, B. Passarelli, J. A. Coller, M. J Fero, H. H. McAdams, and L. Shapiro. 2011. The essential genome of a bacterium. Mol. Syst. Biol. 7:doi: msb.2011.58.
4. Erlich, Y., K. Chang, A. Gordon, R. Ronen, O. Navon, M. Rooks, and G. J. Hannon. 2009. DNA Sudoku-harnessing high-throughput sequencing for multiplexed specimen analysis. Genome Res. 19:1243-1253.
5. Fisher, P., C. Hedeler, K. Wolstencroft, H. Hulme, H. Noyes, S. Kemp, R. Stevens, and A. Brass. 2007. A systematic strategy for large-scale analysis of genotype-phenotype correlations: identifi{dotless}cation of candidate genes involved in African trypanosomiasis. Nucleic Acids Res. 35:5625-5633.
6. Harper, M., S. Nelson, Z. Chen, L. Machado, J. Liao, T. Toy, and C. Lee. 2011. Phenotype sequencing: identifying the genes that cause a phenotype directly from pooled sequencing of independent mutants. PLoS ONE 6:e16517, doi:10.1371/journal.pone.0016517.
7. Lee, D. H., and B. O. Palsson. 2010. Adaptive evolution of Escherichia coli K-12 MG1655 during growth on a nonnative carbon source, l-1,2-propanediol. Appl. Environ. Microbiol. 7:4158-4168.