Electrocortical changes associated with minocycline treatment in fragile X syndrome

Journal of Psychopharmacology

Volumn 27, Issue 10, 2013, Pages 956-963

  Schneider, Andrea ^a,b   Leigh, Mary Jacena ^b   Adams, Patrick ^a,b   Nanakul, Rawi ^c   Chechi, Tasleem ^a,b   Olichney, John ^b   Hagerman, Randi ^a,b   Hessl, David ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cortical parameters; EEG; ERP; Fragile X syndrome; minocycline

Indexed keywords

MINOCYCLINE; PLACEBO;

AMPLITUDE MODULATION; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CHILD; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; ELECTROCORTICAL CHANGE; ELECTROENCEPHALOGRAM; EVENT RELATED POTENTIAL; FEASIBILITY STUDY; FEMALE; FRAGILE X SYNDROME; HUMAN; LATENT PERIOD; MAJOR CLINICAL STUDY; MALE; NERVOUS SYSTEM PARAMETERS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SENSITIVITY ANALYSIS; STIMULUS RESPONSE; TREATMENT DURATION;

CORTICAL PARAMETERS; EEG; ERP; FRAGILE X SYNDROME; MINOCYCLINE;

ANTI-BACTERIAL AGENTS; BIOMARKERS, PHARMACOLOGICAL; CHILD; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EVOKED POTENTIALS, AUDITORY; FEMALE; FRAGILE X SYNDROME; HABITUATION, PSYCHOPHYSIOLOGIC; HUMANS; MALE; MINOCYCLINE;

EID: 84883887715     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881113494105     Document Type: Article

References (30)

1. Bear MF, Huber KM, Warren ST. The mGluR theory of fragile X mental retardation. Trends Neurosci. 2004 ; 27: 370-377
2. Berry-Kravis E. Epilepsy in fragile X syndrome. Dev Med Child Neurol. 2002 ; 44: 724-728
3. Bilousova TV, Dansie L, Ngo M, et al. Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J Med Genet. 2009 ; 46: 94-102
4. Castren M, Paakkonen A, Tarkka IM, et al. Augmentation of auditory N1 in children with fragile X syndrome. Brain Topogr. 2003 ; 15: 165-171
5. Chuang SC, Zhao W, Bauchwitz R, et al. Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model. J Neurosci. 2005 ; 25: 8048-8055
6. D'Hulst C, Kooy RF. The GABAA receptor: A novel target for treatment of fragile X?. Trends Neurosci. 2007 ; 30: 425-431
7. Duncan CC, Barry RJ, Connolly JF, et al. Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clin Neurophysiol. 2009 ; 120: 1883-1908
8. Ferri R, Del Gracco S, Elia M, et al. Somatosensory evoked potentials and hyperekplexia outcome. Neurophysiol Clin. 1995 ; 25: 28-30
9. Guy W ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: U.S. Department of Health, Education, and Welfare ; 1976 :
10. Hessl D, Berry-Kravis E, Cordeiro L, et al. Prepulse inhibition in fragile X syndrome: feasibility, reliability, and implications for treatment. Am J Med Genet B Neuropsychiatr Genet. 2009 ; 150B: 545-553
11. Irwin SA, Patel B, Idupulapati M, et al. Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: A quantitative examination. Am J Med Genet A. 2001 ; 98: 161-167
12. Jacquemont S, Curie A, des Portes V, et al. Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056. Sci Transl Med. 2011 ; 3: 64ra61
13. Leigh MJ ND, Winarni TI, Rivera SM, et al. A double blind, placebo controlled trial of minocycline in children with fragile X syndrome. Pediatric Academic Societies Annual Meeting ; 2012 Boston, MA ; 2012..
14. Musumeci SA, Bosco P, Calabrese G, et al. Audiogenic seizures susceptibility in transgenic mice with fragile X syndrome. Epilepsia. 2000 ; 41: 19-23
15. Musumeci SA, Elia M, Ferri R, et al. Evoked spikes and giant somatosensory evoked potentials in a patient with fragile-X syndrome. Ital J Neurol Sci. 1994 ; 15: 365-368
16. Musumeci SA, Hagerman RJ, Ferri R, et al. Epilepsy and EEG findings in males with fragile X syndrome. Epilepsia. 1999 ; 40: 1092-1099
17. Naatanen R, Kujala T, Escera C, et al. The mismatch negativity (MMN) - a unique window to disturbed central auditory processing in ageing and different clinical conditions. Clin Neurophysiol. 2011 ; 123: 424-458
18. Paribello C, Tao L, Folino A, et al. Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC Neurol. 2010 ; 10: 91
19. Perrin F, Pernier J, Bertrand O, et al. Spherical splines for scalp potential and current density mapping. Electroencephalogr Clin Neurophysiol. 1989 ; 72: 184-187
20. Picton TW, Bentin S, Berg P, et al. Guidelines for using human event-related potentials to study cognition: Recording standards and publication criteria. Psychophysiology. 2000 ; 37: 127-152
21. Rojas DC, Benkers TL, Rogers SJ, et al. Auditory evoked magnetic fields in adults with fragile X syndrome. Neuroreport. 2001 ; 12: 2573-2576
22. Schneider A, Hagerman RJ, Hessl D. Fragile X syndrome - from genes to cognition. Dev Disabil Res Rev. 2009 ; 15: 333-342
23. Schneider A, Leigh MJ, Adams P, et al. Differences in Cortical Hyperexcitability in Fragile X Syndrome. 13th international fragile X conference ; 2012 Miami, FL, USA ; 2012..
24. Sutcliffe JS, Nelson DL, Zhang F, et al. DNA methylation represses FMR-1 transcription in fragile X syndrome. Hum Mol Genet. 1992 ; 1: 397-400
25. Tenke CE, Kayser J. Generator localization by current source density (CSD): Implications of volume conduction and field closure at intracranial and scalp resolutions. Clin Neurophysiol. 2012 ;:
26. Utari A, Chonchaiya W, Rivera SM, et al. Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures. Am J Intellect Dev Disabil. 2010 ; 115: 433-443
27. Van der Molen MJ, Van der, Molen MW, Ridderinkhof KR, et al. Auditory and visual cortical activity during selective attention in fragile X syndrome: a cascade of processing deficiencies. Clin Neurophysiol. 2011a ; 123: 720-729
28. Van der Molen MJ, Van der, Molen MW, Ridderinkhof KR, et al. Auditory change detection in fragile X syndrome males: A brain potential study. Clin Neurophysiol. 2011b ; 123: 1309-1318
29. Van der Molen MJ, Van der, Molen MW, Ridderinkhof KR, et al. Attentional set-shifting in fragile X syndrome. Brain Cogn. 2012 ; 78: 206-217
30. Zhong J, Chuang SC, Bianchi R, et al. BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability. J Neurosci. 2009 ; 29: 9977-9986 Development