Dean flow fractionation (DFF) isolation of circulating tumor cells (CTCs) from blood

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

Volumn 1, Issue , 2011, Pages 524-526

  Bhagat, Ali Asgar S ^a   Hou, Han Wei ^a,b   Li, Leon D ^c   Lim, Chwee Teck ^a,b,d   Han, Jongyoon ^a,e,f  

^a SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e Department of Electrical Engineering and Computer Science   (United States)

^f USA   (United States)

Author keywords

Circulating tumor cells; Dean flows; Inertial forces; Spiral channels

Indexed keywords

CANCER BIOMARKERS; CIRCULATING TUMOR CELLS; DEAN FLOWS; HIGH-THROUGHPUT TECHNIQUE; INERTIAL FORCES; SAMPLE PROCESSING; SEPARATION PRINCIPLE; SPIRAL CHANNEL;

BLOOD; CELLS;

MOLECULAR BIOLOGY;

EID: 84883816240     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (6)

1. Pantel, K., R.H. Brakenhoff, and B. Brandt, Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nature Reviews Cancer, 2008. 8(5): p. 329-340.
2. Nagrath, S., et al., Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature, 2007. 450(7173): p. 1235-1239.
3. Sieuwerts, A.M., et al., Anti-Epithelial Cell Adhesion Molecule Antibodies and the Detection of Circulating Normal-Like Breast Tumor Cells. Journal of the National Cancer Institute, 2009. 101(1): p. 61-66.
4. Bhagat, A.A.S., et al., Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation. Lab Chip, 2011. 11: p. 1870-1878.
5. Bhagat, A.A.S., S.S. Kuntaegowdanahalli, and I. Papautsky, Continuous particle separation in spiral microchannels using dean flows and differential migration. Lab on a chip, 2008. 8(11): p. 1906-1914.
6. Russom, A., et al., Differential inertial focusing of particles in curved low-aspect-ratio microchannels. New journal of physics, 2009. 11: p. 075025.