Adjuvant breast cancer vaccine improves disease specific survival of breast cancer patients with depressed lymphocyte immunity

Surgical Oncology

Volumn 22, Issue 3, 2013, Pages 172-177

  Elliott, Robert L ^a,b   Head, Jonathan F ^a,b  

^a Elliott Elliott Head Breast Cancer Research and Treatment Center   (United States)

^b Sallie Astor Burdine Breast Foundation   (United States)

Author keywords

Adjuvant therapy; Autologous cells; Breast cancer; Cancer vaccine; Lymphocyte Blastogenesis Assay

Indexed keywords

CANCER VACCINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; IMMUNOLOGICAL ADJUVANT; PROGESTERONE RECEPTOR; TAMOXIFEN; TUMOR ANTIGEN;

BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER IMMUNIZATION; CANCER IMMUNOTHERAPY; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; CELLULAR IMMUNITY; CHILL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; FEMALE; FEVER; FOLLOW UP; HUMAN; IMMUNOASSAY; IMMUNOCOMPETENCE; INJECTION SITE PAIN; INJECTION SITE SWELLING; LYMPHOCYTE; LYMPHOCYTE TRANSFORMATION; MASTECTOMY; PRIORITY JOURNAL; REVIEW; TUMOR CELL;

ADJUVANT THERAPY; AUTOLOGOUS CELLS; BREAST CANCER; CANCER VACCINE; LYMPHOCYTE BLASTOGENESIS ASSAY;

ADJUVANTS, IMMUNOLOGIC; BREAST NEOPLASMS; CANCER VACCINES; FEMALE; HUMANS; IMMUNOTHERAPY; LYMPHOCYTES; PROGNOSIS; SURVIVAL RATE;

EID: 84883797109     PISSN: 09607404     EISSN: 18793320     Source Type: Journal    
DOI: 10.1016/j.suronc.2013.05.003     Document Type: Review

References (23)

1. S.M. Watkins Cancer prognosis predicated by preoperative lymphocyte responsiveness in vitro Br J Surg 63 1976 433 434
2. J.H. Dean, R. Conner, R.B. Herberman, J. Silva, J.L. McCoy, and R.K. Oldham The relative proliferation index as a more sensitive parameter for evaluating lymphoproliferative responses of cancer patients to mitogens and alloantigens Int J Cancer 20 1977 359 370
3. L.J. Humphrey, O. Singla, and F.J. Volenec Immunologic responsiveness of the breast cancer patient Cancer 46 1980 893 898
4. S.E. Krown, C.M. Pinsky, H.J. Wanebo, D.W. Braun, P.P. Wong, and H.F. Oettgen Immunologic reactivity and prognosis in breast cancer Cancer 46 1980 1746 1752
5. L.G. Humphrey, M.A. Humphrey, O.M. Singla, and F.J. Volence Immunologic responsiveness of patients with cancer: relationship to tumor type, stage and prognosis Ann Surg 193 1981 574 587
6. G.B. Cannon, J.H. Dean, R.B. Herberman, M. Keels, and C. Alford Lymphoproliferative responses to autologous tumor extracts as prognostic indicators in patients with resected breast cancer Int J Cancer 27 1981 131 138
7. A. Burford-Mason, G.M. Gyte, and S.M. Watkins Phytohaemagglutinin responsiveness of peripheral lymphocytes and survival in patients with primary breast cancer Breast Cancer Res Treat 13 1989 243 250
8. L. Humphrey, and O. Singla Immune responsiveness of patients with malignant melanoma and carcinoma of the breast Semin Surg Oncol 7 1991 230 238
9. J.H. Dean, J.L. McCoy, G.B. Cannon, C.M. Leonard, E. Perlin, and A. Kreutner Cell-mediated immune responses of breast cancer patients to autologous tumor-associated antigens J Natl Cancer Inst 58 1977 549 555
10. J.F. Head, F. Wang, R.L. Elliott, and J.L. McCoy Assessment of immunologic competence and host reactivity against tumor antigens in breast cancer patients Ann N Y Acad Sci 690 1993 340 342
11. J.F. Head, R.L. Elliott, and J.L. McCoy Evaluation of lymphocyte immunity in breast cancer patients Breast Cancer Res Treat 26 1993 77 88
12. X.P. Jiang, D.C. Yang, R.L. Elliott, and J.F. Head Vaccination with a mixed vaccine of autogenous and allogeneic breast cancer cells and tumor associated antigens CA15-3, CEA and CA125 - results in immune and clinical responses in breast cancer patients Cancer Biother Radiopharm 15 2000 495 505
13. X.P. Jiang, D.C. Yang, R.L. Elliott, and J.F. Head Reduction in serum IL-6 after vaccination of breast cancer patients with tumour-associated antigens is related to estrogen receptor status Cytokine 12 2000 458 465
14. Z. Abdel-Wahab, C. Weltz, D. Hester, N. Pickett, C. Vervaert, and J.R. Barber A phase I clinical trial of immunotherapy with interferon-γ gene-modified autologous melanoma cells: monitoring the humoral immune response Cancer 80 1997 401 412
15. K.L. Knutson, V. Schiffman, K. Rinn, and M.L. Disis Immunotherapeutic approaches for the treatment of breast cancer J Mammary Gland Biol Neoplasia 4 1999 353 365
16. J. Schlom, P.M. Arlen, and J.L. Gulley Cancer vaccines: moving beyond current paradigms Clin Cancer Res 13 2007 3776 3782
17. F.M. Burnet The concept of immunological surveillance Prog Exp Tumor Res 13 1970 1 27
18. G. Curigliano, G. Spitaleri, E. Pietri, M. Rescigno, F. de Braud, and A. Cardillo Breast cancer vaccines: a clinical reality or fairy tale? Ann Oncol 17 2006 750 762
19. B. Peng, L. Liang, Z. Chen, Q. He, M. Kuang, and F. Zhou Autologous tumor vaccine lowering postsurgical recurrent rate of hepatocellular carcinoma Hepatogastroenterology 53 2006 409 414
20. C.A. Uyl-de Groot, J.B. Vermorken, M.G. Hanna, P. Verboom, M.T. Groot, and G.J. Bonsel Immunotherapy with autologous tumor cell-BCG vaccine in patients with colon cancer: a prospective study of medical and economic benefits Vaccine 23 2005 2379 2387
21. M.G. Hanna Jr., H.C. Hoover Jr., J.B. Vermorken, J.E. Harris, and H.M. Pinedo Adjuvant active specific immunotherapy of stage II and stage III colon cancer with an autologous tumor cell vaccine: first randomized phase III trials show promise Vaccine 19 2001 2576 2582
22. E. Gilboa The promise of cancer vaccines Nat Rev Cancer 4 2004 401 411
23. A. Toubaji, S. Hill, M. Terabe, J. Qian, T. Floyd, and R.M. Simpson The combination of GM-CSF and IL-2 as local adjuvant shows synergy in enhancing peptide vaccines and provides long term tumor protection Vaccine 25 2007 5882 5891