Dexamethasone intravitreal implant in combination with laser photocoagulation for the treatment of diffuse diabetic macular edema

Ophthalmology

Volumn 120, Issue 9, 2013, Pages 1843-1851

  Callanan, David G ^a   Gupta, Sunil ^b   Boyer, David S ^c   Ciulla, Thomas A ^d   Singer, Michael A ^e   Kuppermann, Baruch D ^f   Liu, Ching Chi ^g   Li, Xiao Yan ^g   Hollander, David A ^g   Schiffman, Rhett M ^g   Whitcup, Scott M ^g  

^a TEXAS RETINA ASSOCIATES   (United States)

^b Retina Specialists Pensacola   (United States)

^c RETINA VITREOUS ASSOCIATES MEDICAL GROUP   (United States)

^d MIDWEST EYE INSTITUTE   (United States)

^e Medical Center Ophthalmology Associates   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE;

ADULT; AGED; BIOMICROSCOPY; CLINICAL EFFECTIVENESS; CONFERENCE PAPER; CONJUNCTIVAL HEMORRHAGE; CONTROLLED STUDY; DIABETIC MACULAR EDEMA; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; INTRAOCULAR PRESSURE; INTRAVITREAL IMPLANT; LASER COAGULATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPTICAL COHERENCE TOMOGRAPHY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA DETACHMENT; RETINA FLUORESCEIN ANGIOGRAPHY; RETINAL THICKNESS; SIDE EFFECT; VISUAL ACUITY; VISUAL IMPAIRMENT;

ADULT; AGED; AGED, 80 AND OVER; CAPILLARY PERMEABILITY; COMBINED MODALITY THERAPY; DEXAMETHASONE; DIABETIC RETINOPATHY; DOUBLE-BLIND METHOD; DRUG IMPLANTS; FEMALE; FLUORESCEIN ANGIOGRAPHY; GLUCOCORTICOIDS; HUMANS; INTRAOCULAR PRESSURE; LASER COAGULATION; MACULAR EDEMA; MALE; MIDDLE AGED; RETINAL VESSELS; TREATMENT OUTCOME; VISUAL ACUITY; VITREOUS BODY;

EID: 84883775340     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2013.02.018     Document Type: Conference Paper

References (30)

1. N. Bhagat, R.A. Grigorian, A. Tutela, and M.A. Zarbin Diabetic macular edema: pathogenesis and treatment Surv Ophthalmol 54 2009 1 32
2. American Diabetes Association Standards of medical care in diabetes - 2009 Diabetes Care 32 suppl 2009 S13 S61
3. Early Treatment Diabetic Retinopathy Study Research Group Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1 Arch Ophthalmol 103 1985 1796 1806
4. Diabetic Retinopathy Clinical Research Network A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema Ophthalmology 115 2008 1447 1449
5. M.J. Elman, L.P. Aiello, R.W. Beck Diabetic Retinopathy Clinical Research Network Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema Ophthalmology 117 2010 1064 1077
6. Q.D. Nguyen, D.M. Brown, D.M. Marcus RISE and RIDE Research Group Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE Ophthalmology 119 2012 789 801
7. K. Miyamoto, S. Khosrof, and S.E. Bursell Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition Proc Natl Acad Sci U S A 96 1999 10836 10841
8. H. Funatsu, H. Noma, and T. Mimura Association of vitreous inflammatory factors with diabetic macular edema Ophthalmology 116 2009 73 79
9. R.J. Antcliff, and J. Marshall The pathogenesis of edema in diabetic maculopathy Semin Ophthalmol 14 1999 223 232
10. J. Wang, X. Xu, and M.H. Elliott Muller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage Diabetes 59 2010 2297 2305
11. H. Tamura, K. Miyamoto, and J. Kiryu Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina Invest Ophthalmol Vis Sci 46 2005 1440 1444
12. K. Wang, Y. Wang, and L. Gao Dexamethasone inhibits leukocyte accumulation and vascular permeability in retina of streptozotocin-induced diabetic rats via reducing vascular endothelial growth factor and intercellular adhesion molecule-1 expression Biol Pharm Bull 31 2008 1541 1546
13. D.A. Antonetti, E.B. Wolpert, and L. DeMaio Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin J Neurochem 80 2002 667 677
14. E.A. Felinski, and D.A. Antonetti Glucocorticoid regulation of endothelial cell tight junction gene expression: novel treatments for diabetic retinopathy Curr Eye Res 30 2005 949 957
15. J.E. Chang-Lin, M. Attar, and A.A. Acheampong Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant Invest Ophthalmol Vis Sci 52 2011 80 86
16. J.A. Haller, B.D. Kuppermann, M.S. Blumenkranz Dexamethasone DDS Phase II Study Group Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema Arch Ophthalmol 128 2010 289 296
17. D.S. Boyer, D. Faber, S. Gupta Ozurdex CHAMPLAIN Study Group Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients Retina 31 2011 915 923
18. I.D. Ladas, and G.P. Theodossiadis Long-term effectiveness of modified grid laser photocoagulation for diffuse diabetic macular edema Acta Ophthalmol (Copenh) 71 1993 393 397
19. J.A. Haller, P. Dugel, and D.V. Weinberg Evaluation of the safety and performance of an applicator for a novel intravitreal dexamethasone drug delivery system for the treatment of macular edema Retina 29 2009 46 51
20. L.P. Aiello, A.R. Edwards, R.W. Beck Diabetic Retinopathy Clinical Research Network Factors associated with improvement and worsening of visual acuity 2 years after focal/grid photocoagulation for diabetic macular edema Ophthalmology 117 2010 946 953
21. P. Mitchell, F. Bandello, U. Schmidt-Erfurth RESTORE Study Group The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema Ophthalmology 118 2011 615 625
22. J.L. Edelman Differentiating intraocular glucocorticoids Ophthalmologica 224 suppl 2010 25 30
23. J.B. Jonas, I. Akkoyun, and B. Kamppeter Intravitreal triamcinolone acetonide for treatment of central retinal vein occlusion Eur J Ophthalmol 15 2005 751 758
24. M.C. Gillies, I.L. McAllister, and M. Zhu Intravitreal triamcinolone prior to laser treatment of diabetic macular edema 24-month results of a randomized controlled trial Ophthalmology 118 2011 866 872
25. V. Dewan, D. Lambert, and J. Edler Cost-effectiveness analysis of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema Ophthalmology 119 2012 1679 1684
26. P.A. Campochiaro, D.M. Brown, A. Pearson FAME Study Group Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema Ophthalmology 119 2012 2125 2132
27. Diabetic Retinopathy Clinical Research Network Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema Ophthalmology 114 2007 525 536
28. M.S. Blumenkranz, J.A. Haller, and B.D. Kuppermann Correlation of visual acuity and macular thickness measured by optical coherence tomography in patients with persistent macular edema Retina 30 2010 1090 1094
29. J.A. Haller, F. Bandello, R. Belfort Ozurdex GENEVA Study Group Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion. Twelve-month study results Ophthalmology 118 2011 2453 2460
30. I. Kozak, V.L. Morrison, and T.M. Clark Discrepancy between fluorescein angiography and optical coherence tomography in detection of macular disease Retina 28 2008 538 544