Serum glycome profiling: A biomarker for diagnosis of ovarian cancer

Journal of Proteome Research

Volumn 12, Issue 9, 2013, Pages 4056-4063

  Biskup, Karina ^a   Braicu, Elena I ^a   Sehouli, Jalid ^a   Fotopoulou, Christina ^a   Tauber, Rudolf ^a   Berger, Markus ^a   Blanchard, Véronique ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

biomarker; mass spectrometry; N glycans; ovarian cancer; serum

Indexed keywords

CA 125 ANTIGEN; GLYCAN; GLYCOPROTEIN; MANNOSE; PLASMA PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CANCER GRADING; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DOWN REGULATION; EARLY DIAGNOSIS; FEMALE; FUCOSYLATION; HISTOLOGY; HUMAN; MAJOR CLINICAL STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METHYLATION; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEOMICS; SENSITIVITY AND SPECIFICITY; STANDARD; TUMOR DIAGNOSIS; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; CA-125 ANTIGEN; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CASE-CONTROL STUDIES; FEMALE; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; POLYSACCHARIDES; ROC CURVE; TUMOR MARKERS, BIOLOGICAL;

EID: 84883761597     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr400405x     Document Type: Article

References (45)

1. GLOBALSCAN Cancer incidence mortality and prevalence worldwide, globoscan.iarc.fr, 2008.
2. Badgwell, D.; Bast, R. C., Jr. Early detection of ovarian cancer Dis. Markers 2007, 23 (5-6) 397-410
3. Fields, M. M.; Chevlen, E. Ovarian cancer screening: A look at the evidence Clin. J. Oncol. Nurs. 2006, 10 (1) 77-81
4. Romero, I.; Bast, R. C., Jr. Minireview: human ovarian cancer: biology, current management, and paths to personalizing therapy Endocrinology 2012, 153 (4) 1593-602
5. W., C. D.; Bast, R. C.; Shih, I. M.; Sokoll, L. J.; Söletermos, G., Tumor markers in ovarian cancer. In Use of tumor markers in testicular, prostate, colorectal, breast and ovarian cancers, Sturgeon, C. M.; Diamandis, E. P., Eds. National Academy of Clinical Biochemistry: Washington, DC, 2009; pp 51-79.
6. Eisenhauer, E. A.; Vermorken, J. B.; van Glabbeke, M. Predictors of response to subsequent chemotherapy in platinum pretreated ovarian cancer: A multivariate analysis of 704 patients [see comments] Ann. Oncol. 1997, 8 (10) 963-8
7. Rustin, G. J. Tumour markers for ovarian cancer Eur. J. Cancer 1992, 28 (1) 2-3
8. Rustin, G. J.; Nelstrop, A. E.; McClean, P.; Brady, M. F.; McGuire, W. P.; Hoskins, W. J.; Mitchell, H.; Lambert, H. E. Defining response of ovarian carcinoma to initial chemotherapy according to serum CA 125 J. Clin. Oncol. 1996, 14 (5) 1545-51
9. Jacobs, I.; Bast, R. C., Jr. The CA 125 tumor-associated antigen: A review of the literature Hum. Reprod. 1989, 4 (1) 1-12
10. van Haaften-Day, C.; Shen, Y.; Xu, F.; Yu, Y.; Berchuck, A.; Havrilesky, L. J.; de Bruijn, H. W.; van der Zee, A. G.; Bast, R. C., Jr.; Hacker, N. F. OVX1, macrophage-colony stimulating factor, and CA-125-II as tumor markers for epithelial ovarian carcinoma: A critical appraisal Cancer 2001, 92 (11) 2837-44
11. Woolas, R. P.; Xu, F. J.; Jacobs, I. J.; Yu, Y. H.; Daly, L.; Berchuck, A.; Soper, J. T.; Clarke-Pearson, D. L.; Oram, D. H.; Bast, R. C., Jr. Elevation of multiple serum markers in patients with stage I ovarian cancer J. Natl. Cancer Inst. 1993, 85 (21) 1748-51
12. Chan, D. W.; Bast, R. C., Jr.; Shih, I. M.; Sokoll, L. J.; Söletormos, G. Tumor Markers in Ovarian Cancer. In Use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers; Sturgeon, C. M.; Diamandis, E. P., Eds.; National Academy of Clinical Biochemistry, Washington, 2009; pp 51-83.
13. Moore, R. G.; Jabre-Raughley, M.; Brown, A. K.; Robison, K. M.; Miller, M. C.; Allard, W. J.; Kurman, R. J.; Bast, R. C.; Skates, S. J. Comparison of a novel multiple marker assay vs the Risk of Malignancy Index for the prediction of epithelial ovarian cancer in patients with a pelvic mass Am. J. Obstet. Gynecol. 2010, 203 (3) 228 e1-6
14. Moore, R. G.; McMeekin, D. S.; Brown, A. K.; DiSilvestro, P.; Miller, M. C.; Allard, W. J.; Gajewski, W.; Kurman, R.; Bast, R. C., Jr.; Skates, S. J. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass Gynecol. Oncol. 2009, 112 (1) 40-6
15. Moore, R. G.; Miller, M. C.; Disilvestro, P.; Landrum, L. M.; Gajewski, W.; Ball, J. J.; Skates, S. J. Evaluation of the diagnostic accuracy of the risk of ovarian malignancy algorithm in women with a pelvic mass Obstet. Gynecol. 2011, 118 (2 Pt 1) 280-8
16. Menon, U.; Jacobs, I. J. Ovarian cancer screening in the general population Curr. Opin. Obstet. Gynecol. 2001, 13 (1) 61-4
17. Jacobs, I. J.; Menon, U. Progress and challenges in screening for early detection of ovarian cancer Mol. Cell. Proteomics 2004, 3 (4) 355-66
18. Yurkovetsky, Z.; Skates, S.; Lomakin, A.; Nolen, B.; Pulsipher, T.; Modugno, F.; Marks, J.; Godwin, A.; Gorelik, E.; Jacobs, I.; Menon, U.; Lu, K.; Badgwell, D.; Bast, R. C.; Lokshin, A. E. Development of a multimarker assay for early detection of ovarian cancer J. Clin. Oncol. 2010, 28 (13) 2159-66
19. Mitoma, J.; Bao, X.; Petryanik, B.; Schaerli, P.; Gauguet, J. M.; Yu, S. Y.; Kawashima, H.; Saito, H.; Ohtsubo, K.; Marth, J. D.; Khoo, K. H.; von Andrian, U. H.; Lowe, J. B.; Fukuda, M. Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment Nat. Immunol. 2007, 8 (4) 409-18
20. Rudd, P. M.; Elliott, T.; Cresswell, P.; Wilson, I. A.; Dwek, R. A. Glycosylation and the immune system Science 2001, 291 (5512) 2370-6
21. Varki, A.; Lowe, J. B. Biological role of glycans. In Essentials of Glycobiology; Varki, A.; Cummings, R.; Esko, J. D.; Freeze, H. H.; Stanley, P.; Bertozzi, C. R.; Hart, G. W.; Etzler, M. E., Eds.; Cold Sring Harbor: New York, 2009; pp 75-88.
22. Kobata, A., Glycoprotein glycan structures. In Comprehensive Glycoscience, from chemistry to Systems Biology; Kamerling, J. P., Ed.; Elsevier: Oxford, 2007; Vol. 1, pp 39-72.
23. Debruyne, E. N.; Vanderschaeghe, D.; Van Vlierberghe, H.; Vanhecke, A.; Callewaert, N.; Delanghe, J. R. Diagnostic value of the hemopexin N-glycan profile in hepatocellular carcinoma patients Clin. Chem. 2010, 56 (5) 823-31
24. Leiserowitz, G. S.; Lebrilla, C.; Miyamoto, S.; An, H. J.; Duong, H.; Kirmiz, C.; Li, B.; Liu, H.; Lam, K. S. Glycomics analysis of serum: A potential new biomarker for ovarian cancer? Int. J. Gynecol. Cancer 2008, 18 (3) 470-5
25. Alley, W. R., Jr.; Vasseur, J. A.; Goetz, J. A.; Svoboda, M.; Mann, B. F.; Matei, D. E.; Menning, N.; Hussein, A.; Mechref, Y.; Novotny, M. V. N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients J. Proteome Res. 2012, 11 (4) 2282-300
26. Turner, G. A.; Goodarzi, M. T.; Thompson, S. Glycosylation of alpha-1-proteinase inhibitor and haptoglobin in ovarian cancer: evidence for two different mechanisms Glycoconj. J. 1995, 12 (3) 211-8
27. Gercel-Taylor, C.; Bazzett, L. B.; Taylor, D. D. Presence of aberrant tumor-reactive immunoglobulins in the circulation of patients with ovarian cancer Gynecol. Oncol. 2001, 81 (1) 71-6
28. Saldova, R.; Royle, L.; Radcliffe, C. M.; Abd Hamid, U. M.; Evans, R.; Arnold, J. N.; Banks, R. E.; Hutson, R.; Harvey, D. J.; Antrobus, R.; Petrescu, S. M.; Dwek, R. A.; Rudd, P. M. Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG Glycobiology 2007, 17 (12) 1344-56
29. Sehouli, J.; Konsgen, D.; Mustea, A.; Oskay-Ozcelik, G.; Katsares, I.; Weidemann, H.; Lichtenegger, W. [″IMO″ - intraoperative mapping of ovarian cancer] Zentralbl. Gynakol. 2003, 125 (3-4) 129-35
30. Sehouli, J.; Richter, R.; Braicu, E. I.; Buhling, K. J.; Bahra, M.; Neuhaus, P.; Lichtenegger, W.; Fotopoulou, C. Role of secondary cytoreductive surgery in ovarian cancer relapse: who will benefit? A systematic analysis of 240 consecutive patients J. Surg. Oncol. 2010, 102 (6) 656-62
31. Sehouli, J.; Savvatis, K.; Braicu, E. I.; Schmidt, S. C.; Lichtenegger, W.; Fotopoulou, C. Primary versus interval debulking surgery in advanced ovarian cancer: results from a systematic single-center analysis Int. J. Gynecol. Cancer 2010, 20 (8) 1331-40
32. Fotopoulou, C.; Richter, R.; Braicu, E. I.; Schmidt, S. C.; Lichtenegger, W.; Sehouli, J. Can complete tumor resection be predicted in advanced primary epithelial ovarian cancer? A systematic evaluation of 360 consecutive patients Eur. J. Surg. Oncol. 2010, 36 (12) 1202-10
33. Fotopoulou, C.; Schumacher, G.; Schefold, J. C.; Denkert, C.; Lichtenegger, W.; Sehouli, J. Systematic evaluation of the intraoperative tumor pattern in patients with borderline tumor of the ovary Int. J. Gynecol. Cancer 2009, 19 (9) 1550-5
34. Wedepohl, S.; Kaup, M.; Riese, S. B.; Berger, M.; Dernedde, J.; Tauber, R.; Blanchard, V. N-glycan analysis of recombinant L-Selectin reveals sulfated GalNAc and GalNAc-GalNAc motifs J. Proteome Res. 2010, 9 (7) 3403-11
35. Dennis, J. W.; Granovsky, M.; Warren, C. E. Glycoprotein glycosylation and cancer progression Biochim. Biophys. Acta 1999, 1473 (1) 21-34
36. Hua, S.; Williams, C. C.; Dimapasoc, L. M.; Ro, G. S.; Ozcan, S.; Miyamoto, S.; Lebrilla, C. B.; An, H. J.; Leiserowitz, G. S. Isomer-specific chromatographic profiling yields highly sensitive and specific potential N-glycan biomarkers for epithelial ovarian cancer J. Chromatogr., A 2013, 1279, 58-67
37. Thompson, S.; Cantwell, B. M.; Matta, K. L.; Turner, G. A. Parallel changes in the blood levels of abnormally-fucosylated haptoglobin and alpha 1,3 fucosyltransferase in relationship to tumour burden: more evidence for a disturbance of fucose metabolism in cancer Cancer Lett. 1992, 65 (2) 115-21
38. Takahashi, N.; Yamamoto, E.; Ino, K.; Miyoshi, E.; Nagasaka, T.; Kajiyama, H.; Shibata, K.; Nawa, A.; Kikkawa, F. High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary Oncol. Rep. 2009, 22 (5) 1027-32
39. Hedlund, M.; Ng, E.; Varki, A.; Varki, N. M. Alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo Cancer Res. 2008, 68 (2) 388-94
40. Kuzmanov, U.; Musrap, N.; Kosanam, H.; Smith, C. R.; Batruch, I.; Dimitromanolakis, A.; Diamandis, E. P. Glycoproteomic identification of potential glycoprotein biomarkers in ovarian cancer proximal fluids Clin. Chem. Lab. Med. 2012, 1-10
41. Wang, P. H.; Lee, W. L.; Juang, C. M.; Yang, Y. H.; Lo, W. H.; Lai, C. R.; Hsieh, S. L.; Yuan, C. C. Altered mRNA expressions of sialyltransferases in ovarian cancers Gynecol. Oncol. 2005, 99 (3) 631-9
42. Montagnana, M.; Danese, E.; Ruzzenente, O.; Bresciani, V.; Nuzzo, T.; Gelati, M.; Salvagno, G. L.; Franchi, M.; Lippi, G.; Guidi, G. C. The ROMA (Risk of Ovarian Malignancy Algorithm) for estimating the risk of epithelial ovarian cancer in women presenting with pelvic mass: is it really useful? Clin. Chem. Lab. Med. 2011, 49 (3) 521-5
43. Montagnana, M.; Danese, E.; Giudici, S.; Franchi, M.; Guidi, G. C.; Plebani, M.; Lippi, G. HE4 in ovarian cancer: from discovery to clinical application Adv. Clin. Chem. 2011, 55, 1-20
44. Fujimura, T.; Shinohara, Y.; Tissot, B.; Pang, P. C.; Kurogochi, M.; Saito, S.; Arai, Y.; Sadilek, M.; Murayama, K.; Dell, A.; Nishimura, S.; Hakomori, S. I. Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects Int. J. Cancer 2008, 122 (1) 39-49
45. Kyselova, Z.; Mechref, Y.; Kang, P.; Goetz, J. A.; Dobrolecki, L. E.; Sledge, G. W.; Schnaper, L.; Hickey, R. J.; Malkas, L. H.; Novotny, M. V. Breast cancer diagnosis and prognosis through quantitative measurements of serum glycan profiles Clin. Chem. 2008, 54 (7) 1166-75