Long-lasting morphofunctional remodelling of liver parenchyma and stroma after a single exposure to low and moderate doses of cadmium in rats

International Journal of Experimental Pathology

Volumn 94, Issue 5, 2013, Pages 343-351

  Cupertino, Marli C ^a   Costa, Kyvia L C ^a   Santos, Daiane C M ^a   Novaes, Rômulo D ^a   Condessa, Suellen S ^a   Neves, Ana C ^a   Oliveira, Juraci A ^a   Matta, Sérgio L P ^a  

^a FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

Author keywords

Fibrosis; Heavy metal; Hepatic injury; Oxidative stress; Toxicology

Indexed keywords

AMINOTRANSFERASE; CADMIUM CHLORIDE; CATALASE; COLLAGEN; COLLAGEN FIBER; FAT DROPLET; GLYCOGEN; SUPEROXIDE DISMUTASE;

AIRWAY REMODELING; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMETRY; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; HEAVY METAL BLOOD LEVEL; HISTOPATHOLOGY; KUPFFER CELL; LIVER CELL; LIVER DISEASE; LIVER EDEMA; LIVER PARENCHYMA; MALE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOLOGY; STROMA;

FIBROSIS; HEAVY METAL; HEPATIC INJURY; OXIDATIVE STRESS; TOXICOLOGY;

ANIMALS; CADMIUM; CATALASE; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; HEPATOCYTES; HOMEOSTASIS; INCIDENCE; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; MODELS, ANIMAL; NECROSIS; RATS; RATS, WISTAR; STROMAL CELLS; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 84883749173     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/iep.12046     Document Type: Article

References (42)

1. Aebi H. (1984) Catalase in vitro. Methods Enzymol. 105, 121-126.
2. Anstee Q.M. & Goldin R.D. (2006) Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int. J. Exp. Pathol. 87, 1-16.
3. Bradford M. (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal. Biochem. 72, 248-254.
4. Cirillo T., Amodio C.R., Fasano E. et al. (2012) Cadmium accumulation and antioxidant responses in Sparus aurata exposed to waterborne cadmium. Arch. Environ. Contam. Toxicol. 62, 118-126.
5. El-Sokkary G., Nafady A., Shabash E. (2009) Melatonin administration ameliorates cadmium-induced oxidative stress and morphological changes in the liver of rat. Ecotoxicol. Environ. Saf. 73, 456-463.
6. El-Tohamy M.M. & El-Nattat W.S. (2010) Effect of antioxidant on lead-induced oxidative damage and reproductive dysfunction in male rabbits. J. Am. Sci. 11, 613-622.
7. Gonçalves R.V., Novaes R.D., Leite J.P.V. et al. (2012) Hepatoprotective effect of Bathysa cuspidata in a murine model of severe toxic liver injury. Int. J. Exp. Pathol. 93, 370-376.
8. Gonçalves R.V., Novaes R.D., Cupertino M.C. et al. (2013) Time-dependent effects of low-level laser therapy on the morphology and oxidative response in the skin wound healing in rats. Lasers Med. Sci. 8, 383-390.
9. Gressner A.M. (1994) Activation of proteoglycan synthesis in injured liver- a brief review of molecular and cellular aspects. Eur. J. Clin. Chem. Clin. Biochem. 32, 225-237.
10. Ikeda Y., Jomura T., Horiuchi U. et al. (2012) Long-term survival and functional maintenance of hepatocytes by using a microfabricated cell array. Colloids Surf. B Biointerfaces. 97, 97-100.
11. Jamall I.S. & Smith J.C. (1985) Effects of cadmium on glutathione peroxidase, superoxide dismutase and lipid peroxidation in the rat heart: a possible mechanism of cadmium cardiotoxicity. Toxicol. Appl. Pharmacol. 80, 33-42.
12. Jamba L., Nehru B., Bansal M.P. (1997) Selenium supplementation during cadmium exposure: changes in antioxidant enzymes and the ultrastructure of the kidney. J. Trace Elem. Exp. Med. 10, 233-242.
13. Jardim E.C., Neto J.M.F., Fichtner S.S. (1979) Proteínas totais, transaminase glutâmica oxalacética e transaminase glutâmica pirúvica em bovinos intoxicados experimentalmente pelo tetracloreto de carbono. Pesq. Agropec. Trop. 9, 15-31.
14. Jomova K. & Valko M. (2011) Advances in metal-induced oxidative stress and human disease. Toxicology 283, 65-87.
15. Jungmann J., Reins H.-A., Schobert C., Jentsch S. (1993) Resistance to cadmium mediated by ubiquitin-dependent proteolysis. Nature 361, 369-371.
16. Manca D., Ricard A.C., Trottier B., Chevalier G. (1991) Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. Toxicology 67, 303-323.
17. Mandarim-de-Lacerda C.A. (2003) Stereological tools in biomedical research. An. Acad. Braz. Cienc. 75, 469-486.
18. Merali Z. & Singhal R.L. (1980) Diabetogenic effects of chronic oral cadmium administration to neonatal rats. Br. J. Pharmacol. 69, 151-157.
19. Naito M., Hasegawa G., Ebe Y., Yamamoto T. (2004) Differentiation and function of Kupffer cells. Med. Electron. Microsc. 37, 16-28.
20. Nolan C.V. & Shaikh Z.A. (1986) The vascular endothelium as a target tissue in acute cadmium toxicity. Life Sci. 39, 1403-1409.
21. Novaes R.D., Gonçalves R.V., Marques D.C.S. et al. (2012a) Effect of bark extract of Bathysa cuspidata on hepatic oxidative damage and blood glucose kinetics in rats exposed to paraquat. Toxicol. Pathol. 40, 62-70.
22. Novaes R.D., Gonçalves R.V., Cupertino M.C. et al. (2012b) Bark extract of Bathysa cuspidata attenuates extra-pulmonary acute lung injury induced by paraquat and reduces mortality in rats. Int. J. Exp. Pathol. 93, 225-233.
23. Novaes R.D., Penitente A.R., Gonçalves R.V. et al. (2013) Trypanosoma cruzi infection induces morphological reorganization of the myocardium parenchyma and stroma, and modifies the mechanical properties of atrial and ventricular cardiomyocytes in rats. Cardiovasc. Pathol. 22, 270-279.
24. Ognjanovic B., Markovic S., Ethordevic N., Trbojevic I., Stajn A., Saicic Z. (2009) Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: protective role of coenzyme Q10 and Vitamin E. Reprod. Toxicol. 29, 191-197.
25. Ognjanović B.I., Marković S.D., Pavlović S.Z., Žikić R.V., Štajn A.Š., Saičić Z.S. (2007) Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: protective effect of selenium. Physiol. Res. 57, 403-411.
26. Ozer J., Ratner M., Shaw M., Bailey W., Schomaker S. (2008) The current state of serum biomarkers of hepatotoxicity. Toxicology 245, 194-205.
27. Patra R.C., Swarup D., Senapati S.K. (1999) Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic, renal and testicular tissue of rats. Vet. Hum. Toxicol. 41, 65-67.
28. Predes F.S. (2010) Efeito antioxidante da bardana (Arctium lappa) no testículo, epidídimo e fígado de ratos danificados pelo cádmio: bioquímica, morfologia, morfometria e ultraestrutura. PhD Thesis. Unicamp, Campinas, São Paulo, 103 p.
29. Ramaiah S.K. (2007) A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters. Food Chem. Toxicol. 45, 1551-1557.
30. Ranawat L., Bhatt J., Patel J. (2010) Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats. J. Ethnopharmacol. 127, 777-780.
31. Sala M.A., Komesu M.C., Lopes R.A., Maia C.G. (1994) Karyometric study of basal cell carcinoma. Braz. Dent. J. 5, 11-14.
32. Sarban S., Kocyigit A., Yazar M., Isikan U.E. (2005) Plasma total antioxidant capacity, lipid peroxidation, and erythrocyte antioxidant enzyme activities in patients with rheumatoid arthritis and osteoarthritis. Clin. Biochem. 38, 981-986.
33. Sarkar S., Yadav P., Bhatnagar D. (1997) Lipid peroxidative damage on cadmium exposure and alterations in antioxidant system in rat erythrocytes: a study with relation to time. Biometals 11, 153-157.
34. Simoniello P., Filosa S., Riggio M. et al. (2010) Responses to cadmium intoxication in the liver of the wall lizard Podarcis sicula. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 151, 194-203.
35. Sreelatha S., Padma P.R., Umadevi M. (2009) Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity. Food Chem. Toxicol. 47, 702-708.
36. Stoev S.D., Grozeva N., Simeonov R. et al. (2003) Experimental cadmium poisoning in sheep. Exp. Toxicol. Pathol. 55, 309-314.
37. Thophon S., Pokethitiyook P., Chalermwat K., Upatham E.S., Sahaphong S. (2004) Ultrastructural alterations in the liver and kidney of white sea bass, Lates calcarifer, in acute and subchronic cadmium exposure. Environ. Toxicol. 19, 11-19.
38. + exchanger present on the brush border membrane vesicles isolated from eel kidney tubular cells. Aquat. Toxicol. 48, 25-36.
39. Waalkes M.P. (2000) Cadmium carcinogenesis in review. J. Inorg. Biochem. 79, 241-244.
40. Wang Y.J., Yuan J., Chu E.S.H. et al. (2011) T1ρMR imaging is sensitive to evaluate liver fibrosis: an experimental study in a rat biliary duct ligation model. Radiology 259, 712-719.
41. Wolf M.B. & Baynes J.W. (2006) Cadmium and mercury cause an oxidative stress-induced endothelial dysfunction. Biometals 20, 73-81.
42. Wright T.M. & Vandenberg A.M. (2007) Risperidone- and quetiapine-induced cholestasis. Ann. Pharmacother. 41, 1518-1523.