Troponin T autoantibodies correlate with chronic cardiomyopathy in human Chagas disease

Tropical Medicine and International Health

Volumn 18, Issue 10, 2013, Pages 1180-1192

  Nunes, Daniela Ferreira ^a   Guedes, Paulo Marcos da Matta ^a   de Mesquita Andrade, Cléber ^a   Câmara, Antonia Cláudia Jácome da ^a   Chiari, Egler ^b   Galvão, Lúcia Maria da Cunha ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Autoantibodies; Human Chagas disease; Immunopathogenesis; Myosin; Troponin T; Trypanosoma cruzi

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3 ANTIBODY; IMMUNOGLOBULIN G4; MYOSIN; PARASITE ANTIGEN; TROPONIN T;

ANTIBODY; ANTIGEN; CARDIOVASCULAR DISEASE; CHAGAS DISEASE; HEALTH CARE; PROTEIN;

ANTIBODY PRODUCTION; ARTICLE; CARDIOMYOPATHY; CHAGAS DISEASE; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; EPIMASTIGOTE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; ISCHEMIC CARDIOMYOPATHY; MAJOR CLINICAL STUDY; RADIOGRAPHY; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

AUTOANTIBODIES; HUMAN CHAGAS DISEASE; IMMUNOPATHOGENESIS; MYOSIN; TROPONIN T; TRYPANOSOMA CRUZI;

ADULT; AGED; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; AUTOANTIBODIES; CASE-CONTROL STUDIES; CHAGAS CARDIOMYOPATHY; CHRONIC DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MYOSINS; RURAL HEALTH; TROPONIN T; TRYPANOSOMA CRUZI; YOUNG ADULT;

TRYPANOSOMA CRUZI;

EID: 84883741053     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/tmi.12169     Document Type: Article

References (49)

1. Abel LC, Rizzo LV, Ianni B et al. (2001) Chronic Chagas' disease cardiomyopathy patients display an increased IFN-γ response to Trypanosoma cruzi infection. Journal of Autoimmunity 17, 99-107.
2. Abel LC, Iwai LK, Viviani W et al. (2005) T cell epitope characterization in tandemly repetitive Trypanosoma cruzi B13 protein. Microbes and Infection 7, 1184-1195.
3. Andrade V, Barral-Neto M & Andrade SG (1985) Patterns of resistance of inbred mice to Trypanosoma cruzi are determined by parasite strain. Brazilian Journal of Medical and Biological Research 18, 499-506.
4. Añez N, Carrasco H, Parada H et al. (1999) Myocardial parasite persistence in chronic chagasic patients. The American Journal of Tropical Medicine and Hygiene 60, 726-732.
5. Bahia-Oliveira LMG, Gomes JAS, Rocha MOC et al. (1998) IFN-γ in human Chagas' disease: protection or pathology? Brazilian Journal of Medical and Biological Research 31, 127-131.
6. Basquiera AL, Capra R, Omelianiuka M et al. (2003) Serum Troponin T in Patients With Chronic Chagas Disease. Revista Española de Cardiología 56, 742-744.
7. Bestetti RB, Dalbo CM, Freitas OC et al. (1994) Noninvasive predictors of mortality for patients with Chagas' heart disease: a multivariate stepwise logistic regression study. Cardiology 84, 261-267.
8. Brasil, Ministério da Saúde (2005) Consenso Brasileiro em Doença de Chagas. Revista da Sociedade Brasileira de Medicina Tropical 30, 12-14.
9. Briere F, Servet-Delprat C, Bridon JM et al. (1994) Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3. Journal of Experimental Medicine 179, 757-762.
10. Brisinda D, Sorbo AR, Venuti A et al. (2012) Anti-β-adrenoceptors autoimmunity causing 'idiopathic' arrhythmias and cardiomyopathy. Circulation Journal 76, 1345-1353.
11. Carrasco HA, Parada H, Guerrero L et al. (1994) Prognostic implications of clinical electrocardiographic and hemodynamic findings in chronic Chagas disease. The International Journal of Cardiology 43, 27-38.
12. Cerban FM, Gea S, Menso E et al. (1993) Chagas' disease: IgG subclasses against Trypanosoma cruzi cytosol acidic antigens in patients with different degrees of heart damage. Clinical Immunology and Immunopathology 67, 25-30.
13. Chagas C & Villela E (1922) Forma cardíaca da tripanossomíase americana. Memórias do Instituto Oswaldo Cruz 14, 5-61.
14. Cordeiro FD, Martins-Filho OA, Rocha MOC et al. (2001) Anti-Trypanosoma cruzi immunoglobulin G1 can be a useful tool for diagnosis and prognosis of humam Chagas' disease. Clinical and Diagnostic Laboratory Immunology 8, 112-118.
15. Cossio PM, Diez D, Szarfman A et al. (1974) Chagasic cardiophaty: demonstration of a serum gamma globin factor which reacts with endocardium and vascular structures. Circulation 49, 13-21.
16. Cunha-Neto E, Duranti M, Gruber A et al. (1995) Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. Proceedings of the National Academy of Sciences USA 92, 3541-3545.
17. Cunha-Neto E, Coelho V, Guilherme L et al. (1996) Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient. The Journal of Clinical Investigation 98, 1709-1712.
18. D'Ávila D, Guedes PMM, Castro AM et al. (2009) Immunological imbalance between IFN-γ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease. Memórias do Instituto Oswaldo Cruz 104, 100-105.
19. Gironès N, Rodríguez CI, Carrasco-Marín E et al. (2001) Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease. The Journal of Clinical Investigation 107, 985-993.
20. Gomes JA, Bahia-Oliveira LM, Rocha MO et al. (2003) Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response. Infection and Immunity 71, 1185-1193.
21. Hernández-Becerril N, Nava A, Reyes PA et al. (2001) IgG subclass reactivity to Trypanosoma cruzi in chronic chagasic patients. Archivos de Cardiologia de Mexico 71, 199-205.
22. Higuchi ML, De Brito T, Reis MM et al. (1993) Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagasic myocarditis: light microscopy and immunohistochemical findings. Cardiovascular Pathology 2, 101-105.
23. Iwai LK, Juliano MA, Juliano L et al. (2005) T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain. Journal of Autoimmunity 24, 111-117.
24. Jahns R, Boivin V, Schwarzbach V et al. (2008) Pathological autoantibodies in cardiomyopathy. Autoimmunity 41, 454-461.
25. Jones ME, Colley DE, Tostes S et al. (1993) Amplification of a Trypanosoma cruzi DNA sequence from inflammatory lesion in human chagasic cardiomyopathy. The American Journal of Tropical Medicine and Hygiene 48, 348-357.
26. Kawano Y, Noma T & Yata J (1994) Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2. Journal of Immunology 153, 4948-4958.
27. Kaya Z, Katus HA & Rose NR (2010) Cardiac troponins and autoimmunity: their role in the pathogenesis of myocarditis and heart failure. Clinical Immunology 134, 80-88.
28. Kierszenbaum F (1986) Autoimmunity in Chagas' disease. The Journal of Parasitology 72, 201-211.
29. Lages-Silva E, Crema E, Ramirez LE et al. (2001) Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism. American Journal of Tropical Medicine and Hygiene 65, 435-441.
30. Lang RM, Bierig M, Devereux RB et al. (2005) Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. Journal of the American Society of Echocardiography. 18, 1440-1463.
31. Lappé JM, Pelfrey CM, Cotleur A & Tang WH (2011) Cellular proliferative response to cardiac troponin-I in patients with idiopathic dilated cardiomyopathy. Clinical and Translational Science 4, 317-322.
32. Laranja FS, Dias E, Nóbrega G et al. (1956) Chagas's disease: a clinical epidemiologic and pathologic study. Circulation 14, 1035-1059.
33. Leon JS, Godsel LM, Wang K et al. (2001) Cardiac myosin autoimmunity in acute Chagas heart disease. Infection and Immunity 69, 5643-5649.
34. Lowry OH, Rosebrough NJ, Farr L et al. (1951) Protein measurement with the folin phenol reagent. The Journal of Biological Chemistry 193, 265-275.
35. Mady C, Cardoso RHA, Barretto ACP et al. (1994) Survival and predictors of survival in patients with congestive heart failure due to Chagas's cardiomyopathy. Circulation 90, 3098-3102.
36. Monteón-Padilla VM, Hernández-Becerril N, Guzmán-Bracho C et al. (1999) American trypanosomiasis (Chagas' disease) and blood banking in México city: seroprevalence and its potential transfucional transmission risk. Archives of Medical Research 30, 393-398.
37. Monteón-Padilla VM, Hernández-Becerril N, Ballinas-Verdugo MA et al. (2001) Persistence of Trypanosoma cruzi in chronic chagasic cardiopathy patients. Archives of Medical Research 32, 39-43.
38. Morgan J, Dias JCP, Gontijo ED et al. (1996) Anti-Trypanosoma cruzi antibody isotype profiles in patients with different clinical manifestations of Chagas' disease. The American Journal of Tropical Medicine and Hygiene 55, 355-359.
39. Prata A (2001) Clinical and epidemiological aspects of Chagas disease. Lancet Infectious Disease 1, 92-100.
40. Reis MM, Higuchi ML, Benvenuti LA et al. (1997) An in situ quantitative immunohistochemical study of cytokines and IL-2R/in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens. Clinical Immunology and Immunopathology 83, 165-172.
41. Ribeiro-dos-Santos R & Hudson L (1981) Denervation and the immune response in mice infected with Trypanosoma cruzi. Clinical & Experimental Immunology 44, 349-354.
42. Rizzo LV, Cunha-Neto E & Teixeira ARL (1989) Autoimmunity in Chagas' disease: specific inhibition of reactivity of CD4 + T cells against myosin in mice chronically infected with Trypanosoma cruzi. Infection and Immunity 57, 2640-2644.
43. Salvatella R (2007). Achievements in Controlling Chagas Disease in Latin America. World Health Organization, Geneva.
44. Saravia SG, Haberland A, Bartel S et al. (2011) Cardiac troponin T mensured with a highly sensitive assay for diagnosis and monitoring of heart injury in chronic chagas disease. Archives of Pathology and Laboratory Medicine 135, 245-248.
45. Tibbetts RS, McCormick TS, Rowland EC et al. (1994) Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice. The Journal of Immunology 152, 1493-1499.
46. Umezawa ES & Silveira JF (1999) Serological diagnosis of Chagas disease with purified and defined Trypanosoma cruzi antigens. Memórias do Instituto Oswaldo Cruz 94, 285-188.
47. Vago AR, Macedo AM, Adad SJ et al. (1996) PCR detection of Trypanosoma cruzi DNA in esophageal tissues of patients with chronic Chagas' disease. Lancet 348, 891-892.
48. Voller A, Bidwell DE & Bartlett A (1976) Enzyme immunoassays in diagnostic medicine: theory and pratice. Bulletin World Health Organization 53, 55-65.
49. World Health Organisation (2010). Chagas Disease: Control and Elimination. Report by the Secretariat. Sixty-third world health assembly. Document A63/17.