Aspartate aminotransferase to platelet ratio index correlates with hepatic cirrhosis but not with fibrosis in pediatric patients with intestinal failure

Journal of Pediatric Gastroenterology and Nutrition

Volumn 57, Issue 3, 2013, Pages 367-371

  Díaz, Juan J ^a   Gura, Kathleen M ^b   Roda, Juliamna ^d   Perez Atayde, Antonio R ^b   Duggan, Christopher ^c   Jaksic, Tom ^c   Lo, Clifford W ^c  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b Department of Pharmacy ^*  (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

diagnostic test; intestinal failure; liver disease; parenteral nutrition

Indexed keywords

ASPARTATE AMINOTRANSFERASE;

ADOLESCENT; ARTICLE; ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX; CHILD; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; FEMALE; HUMAN; HUMAN TISSUE; INFANT; INTESTINAL FAILURE; LIVER BIOPSY; LIVER CIRRHOSIS; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NON INVASIVE PROCEDURE; PARENTERAL NUTRITION; PRESCHOOL CHILD; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SCORING SYSTEM; THROMBOCYTE; ADULT; AREA UNDER THE CURVE; BIOPSY; BLOOD; FIBROSIS; INTESTINAL DISEASES; LIVER; METABOLISM; PATHOLOGY; REPRODUCIBILITY; RISK; THROMBOCYTE COUNT; VALIDATION STUDY; YOUNG ADULT;

ADOLESCENT; ADULT; AREA UNDER CURVE; ASPARTATE AMINOTRANSFERASES; BIOPSY; BLOOD PLATELETS; CHILD; CHILD, PRESCHOOL; FEMALE; FIBROSIS; HUMANS; INFANT; INTESTINAL DISEASES; LIVER; LIVER CIRRHOSIS; MALE; ODDS RATIO; PARENTERAL NUTRITION; PLATELET COUNT; REPRODUCIBILITY OF RESULTS; ROC CURVE; YOUNG ADULT;

EID: 84883740808     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e318299fdbd     Document Type: Article

References (26)

1. Goulet O, Ruemmele F. Causes and management of intestinal failure in children. Gastroenterology 2006; 130(2 suppl 1):S16-28. (Pubitemid 43208856)
2. Duro D, Kamin D, Duggan C. Overview of pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr 2008; 47(SUPPL. 1):S33-6.
3. Nehra D, Fallon EM, Puder M. The prevention and treatment of intestinal failure-associated liver disease in neonates and children. Surg Clin North Am 2011; 91: 543-63.
4. Zambrano E, El-Hennawy M, Ehrenkranz R.A., et al. Total parenteral nutrition induced liver pathology: an autopsy series of 24 newborn cases. Pediatr Dev Pathol 2004; 7: 425-32. (Pubitemid 40385233)
5. Van Thiel D.H., Gavaler JS, Wright H, et al Liver biopsy. Its safety and complications as seen at a liver transplant center. Transplantation 1993; 55(5): 1087-90. (Pubitemid 23150741)
6. Bedossa P, Dargère D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 2003; 38: 1449-57. (Pubitemid 37466971)
7. Colloredo G, Guido M, Sonzogni A., et al. Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease. J Hepatol 2003; 39: 239-44. (Pubitemid 36920560)
8. Regev A, Berho M, Jeffers L.J., et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 2002; 97: 2614-8.
9. Imbert-Bismut F., Ratziu V, Pieroni L., et al. Biochemical markersof liver fibrosis in patients with hepatitis C virus infection: a prospective study. Lancet 2001; 357: 1069-75. (Pubitemid 32322537)
10. Sandrin L, Fourquet B, Hasquenoph J.M., et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29: 1705-13. (Pubitemid 38091720)
11. Wai CT, Greenson JK, Fontana R.J., et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 2003; 38: 518-26. (Pubitemid 36919874)
12. Kim SY, Seok JY, Han S.J., et al. Assessment of liver fibrosis and cirrhosis by aspartate aminotransferase-to-platelet ratio index in children with biliary atresia. J Pediatr Gastroenterol Nutr 2010; 51: 198-202.
13. McGoogan KE, Smith PB, Choi S.S., et al. Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis. J Pediatr Gastroenterol Nutr 2010; 50: 344-6.
14. Lebensztejn DM, Skiba E, Sobaniec-Lotowska M, et al. A simple noninvasive index (APRI) predicts advanced liver fibrosis in children with chronic hepatitis B. Hepatology 2005; 41: 1434-5. (Pubitemid 40770297)
15. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group. Hepatology 1994; 20: 15.
16. Cadranel JF, Rufat P, Degos F. Practices of liver biopsy in France: results of a prospective nationwide survey. Group of Epidemiology of the French Association for the Study of the Liver (AFEF). Hepatology 2000; 32: 477-81.
17. McGill DB, Rakela J, Zinsmeister A.R., et al. A 21-year experience with major hemorrhage after percutaneous liver biopsy. Gastroenterology 1990; 99: 1396-400. (Pubitemid 20381876)
18. Lachaux A, Le Gall C, Chambon M, et al. Complications of percutaneous liver biopsy in infants and children. Eur J Pediatr 1995; 154: 621-3.
19. Foucher J, Chanteloup E, Vergniol J., et al. Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 2006; 55: 403-8. (Pubitemid 43268281)
20. Duro D, Fitzgibbons S, Valim C., et al. [13C]Methionine breath test to assess intestinal failure-associated liver disease. Pediatr Res 2010; 68: 349-54.
21. Lin ZH, Xin YN, Dong Q.J., et al. Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis. Hepatology 2011; 53: 726-36.
22. Yang HR, Kim HR, Kim M.J., et al. Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease. World J Gastroenterol 2012; 18: 1525-30.
23. de Lédinghen V, Le Bail B, Rebouissoux L, et al. Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy. J Pediatr Gastroenterol Nutr 2007; 45: 443-50. (Pubitemid 350307163)
24. Lind RC, Verkade HJ, Porte R.J., et al. Aspartate transaminase-to- platelet ratio index is not correlated with severity of fibrosis or survival in children with biliary atresia. J Pediatr Gastroenterol Nutr 2012; 54: 698.
25. Mangus RS, O'Connor MG, Tector AJ, et al Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut. J Pediatr Surg 2010; 45: 1266-73.
26. O'Connor M., Mangus RS, Tector A.J., et al. Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths. J Pediatr Surg 2011; 46: 1057-63. Development