A dietary embryo/fetal developmental toxicity study of arruva, an R,R-monatin salt isomer, in Crl: CD(SD) rats

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 68-75

  Brathwaite, W A ^a   Casterton, P L ^b   Nikiforov, A I ^c   Rihner, M O ^c   Sloter, E D ^d   Hlywka, J J ^e  

^a Cargill Limited   (Canada)

^b CARGILL INC   (United States)

^c Toxicology Regulatory Services   (United States)

^d WIL RESEARCH LABORATORIES   (United States)

^e Kraft Foods Global LLC   (United States)

Author keywords

Arruva; Embryotoxicity; Fetal development; Oral; R,R monatin; Sweetener

Indexed keywords

ARRUVA; SWEETENING AGENT; UNCLASSIFIED DRUG; 4-HYDROXY-4-(INDOL-3-YLMETHYL)GLUTAMIC ACID; GLUTAMIC ACID; INDOLE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DEVELOPMENTAL TOXICITY; EMBRYO; EMBRYOTOXICITY; FEMALE; FETUS; FETUS MALFORMATION; FETUS WEIGHT; GESTATIONAL AGE; INTRAUTERINE SURVIVAL; MATERNAL TOXICITY; NONHUMAN; PREGNANCY; RAT; SURVIVAL; TOXICITY; WEIGHT GAIN; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL FOOD; CHEMICALLY INDUCED; DIET; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MATERNAL EXPOSURE; MULTIPLE MALFORMATION SYNDROME; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PROCEDURES; SPRAGUE DAWLEY RAT; TOXICITY TESTING; UTERUS;

ABNORMALITIES, MULTIPLE; ANIMAL FEED; ANIMALS; BODY WEIGHT; DIET; FEMALE; FETAL WEIGHT; GLUTAMIC ACID; INDOLES; MALE; MATERNAL EXPOSURE; MICE, INBRED ICR; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PREGNANCY; RATS, SPRAGUE-DAWLEY; SWEETENING AGENTS; TOXICITY TESTS; UTERUS;

EID: 84883719952     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.027     Document Type: Article

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