A case report of a patient with advanced acinar cell carcinoma of the pancreas: Long-term survival with regional, systemic and targeted therapy

Tumori

Volumn 99, Issue 2, 2013, Pages

  Ang, Celina ^a   Herran, Luis A ^b   Lagunes, Diane Reidy ^a   Klimstra, David S ^a   Kemeny, Nancy E ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ASTELLAS PHARMA GLOBAL DEVELOPMENT   (United States)

Author keywords

Acinar cell carcinoma of the pancreas; Molecular biology; Therapy

Indexed keywords

BEVACIZUMAB; CETUXIMAB; CISPLATIN; DEXAMETHASONE; FLOXURIDINE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; OXALIPLATIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORODEOXYGLUCOSE F 18; MONOCLONAL ANTIBODY; PLATINUM COMPLEX; RADIOPHARMACEUTICAL AGENT; TUMOR MARKER;

ABDOMINAL DISCOMFORT; ACINAR CELL CARCINOMA; ADVANCED CANCER; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER CHEMOTHERAPY; CANCER THERAPY; CASE REPORT; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPEPSIA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY FAILURE; LIVER BIOPSY; LIVER METASTASIS; LONG TERM SURVIVAL; MALE; MOLECULARLY TARGETED THERAPY; PANCREAS CARCINOMA; CHEMISTRY; IMMUNOHISTOCHEMISTRY; LIVER TUMOR; METASTASIS; METHODOLOGY; PANCREAS TUMOR; PATHOLOGY; TREATMENT OUTCOME;

AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; CARCINOMA, ACINAR CELL; FLUORODEOXYGLUCOSE F18; FLUOROURACIL; HUMANS; IMMUNOHISTOCHEMISTRY; LEUCOVORIN; LIVER NEOPLASMS; MALE; MOLECULAR TARGETED THERAPY; ORGANOPLATINUM COMPOUNDS; PANCREATIC NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84883641376     PISSN: 03008916     EISSN: 20382529     Source Type: Journal    
DOI: 10.1700/1283.14209     Document Type: Article

References (14)

1. Klimstra DS, Heffess CS, Oertel JE, Rosai J: Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. Am J Surg Pathol, 16: 815-837,1992.
2. Holen KD, Klimstra DS, Hummer A, Gonen M, Conlon K, Brennan M, Saltz LB: Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors. J Clin Oncol, 20: 4673-4678, 2002.
3. Seth AK, Argani P, Campbell KA, Cameron JL, Pawlik TM, Schulick RD, Choti MA, Wolfgang CL: Acinar cell carcinoma of the pancreas: an institutional series of resected patients and review of the current literature. J Gastrointest Surg, 12: 1061-1067, 2008.
4. Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, O'Reilly EM: Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy. Oncologist, 16: 1714-1720, 2011.
5. Shimizu E, Kikuyama M, Hashimoto M, Murohisa G, Suzuki F, Tsugiki M, Souda K, Kobayashi Y, Kawasaki T, Yoshimi T: A case of alpha-fetoprotein producing pancreatic carcinoma, review of 41 cases reported in Japan. Nippon Shokakibyo Gakkai Zasshi, 93: 921-926, 1996.
6. Kitagami H, Kondo S, Hirano S, Kawakami H, Egawa S, Tanaka M: Acinar cell carcinoma of the pancreas: clinical analysis of 115 patients from Pancreatic Cancer Registry of the Japan Pancrease Society. Pancreas, 35: 42-46, 2007.
7. Abraham SC, Wu TT, Hruban RH, Lee JH, Yeo CJ, Conlon K, Brennan M, Cameron JL, Klimstra DS: Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Path, 160: 953-962, 2002.
8. Hartwig W, Denneberg M, Bergmann F, Hackert T, Hinz U, Strobel O, Buchler MW, Werner J: Acinar cell carcinoma of the pancreas: is resection justified even in limited metastatic disease? Am J Surg, 202: 23-27, 2011.
9. Suzuki A, Sakaguchi T, Morita Y, Oishi K, Fukumoto K, Inaba K, Takehara Y, Baba S, Suzuki S, Konno H: Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: report of a case. Surg Today, 40: 679-683, 2010.
10. Antoine M, Khitrik-Palchuk M, Saif MW: Long-term survival in a patient with acinar cell carcinoma of the pancreas. A case report and review of the literature. JOP, 8: 783-789, 2007.
11. Kemeny N: The management of resectable and unresectable liver metastases from colon cancer. Curr Opin Oncol, 22: 364-373, 2010.
12. Chua TC, Saxena A, Liauw W, Chu F, Morris DL: Hepatectomy and resection of concomitant extrahepatic disease for colorectal liver metastases - a systematic review. Eur J Cancer, 48: 1757-1765, 2012.
13. Hoorens A, Lemoine NR, McLellan E, Morohoshi T, Kamisawa T, Heitz PU, Stamm B, Ruschoff J, Widenmann B, Kloppel G: Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation. Am J Pathol, 143: 685-698, 1993.
14. Armstrong MD, Von Hoff D, Barber B, Marlow LA, von Roemeling C, Cooper SJ, Travis P, Campbell E, Paz-Fumagalli R, Copland JA, Colon-Otero G: An effective personalized approach to a rare tumor: prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development. J Cancer, 2: 142- 152, 2011.