A New Approach for the Study of Lung Smooth Muscle Phenotypes and Its Application in a Murine Model of Allergic Airway Inflammation

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Paez Cortez, Jesus ^a   Krishnan, Ramaswamy ^b   Arno, Anneliese ^a   Aven, Linh ^a   Ram Mohan, Sumati ^b   Patel, Kruti R ^a   Lu, Jining ^a   King, Oliver D ^c   Ai, Xingbin ^a   Fine, Alan ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOCHROME P450 2E1; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERLEUKIN 13 RECEPTOR ALPHA2; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OVALBUMIN;

ADRB2 GENE; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOPHYSICS; BRONCHUS MUSCLE; CELL ISOLATION; CELL POPULATION; CELL SELECTION; CELL SIZE; COL6A5 GENE; CONTROLLED STUDY; CXCL5 GENE; CYP2EE1 GENE; DISEASE SEVERITY; DOWN REGULATION; EX VIVO STUDY; GENE; GENE EXPRESSION; IL13RA2 GENE; LCN2 GENE; MOUSE; NONHUMAN; PHENOTYPE; PURIFICATION; SENSITIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ALLERGENS; ANIMALS; ASTHMA; BRONCHI; BRONCHIAL HYPERREACTIVITY; CELL SIZE; DISEASE MODELS, ANIMAL; FLUORESCENCE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNIZATION; INFLAMMATION; MICE; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OVALBUMIN; PHENOTYPE; PROTEOME; RNA, MESSENGER; SINGLE-CELL ANALYSIS;

EID: 84883615741     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074469     Document Type: Article

References (25)

1. Damera G, Tliba O, Panettieri RA Jr, (2009) Airway smooth muscle as an immunomodulatory cell. Pulm Pharmacol Ther 22: 353-359.
2. Jarai G, Sukkar M, Garrett S, Duroudier N, Westwick J, et al. (2004) Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays. Eur J Pharmacol 497: 255-265.
3. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, et al. (2001) Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol 25: 474-485.
4. Woodruff PG, (2008) Gene expression in asthmatic airway smooth muscle. Proc Am Thorac Soc 5: 113-118.
5. Ozier A, Allard B, Bara I, Girodet PO, Trian T, et al. (2011) The pivotal role of airway smooth muscle in asthma pathophysiology. J Allergy (Cairo) 2011: 742710.
6. An SS, Fabry B, Trepat X, Wang N, Fredberg JJ, (2006) Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am J Respir Cell Mol Biol 35: 55-64.
7. Siddiqui S, Redhu NS, Ojo OO, Liu B, Irechukwu N, et al. (2013) Emerging airway smooth muscle targets to treat asthma. Pulm Pharmacol Ther 26: 132-144.
8. Raja SG, Raja SM, (2011) Treating pulmonary arterial hypertension: current treatments and future prospects. Ther Adv Chronic Dis 2: 359-370.
9. Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, et al. (2011) Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem 286: 22678-22687.
10. Zhu X, Bergles DE, Nishiyama A, (2008) NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development 135: 145-157.
11. Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, et al. (2007) Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol 178: 8081-8089.
12. Boxall C, Holgate ST, Davies DE, (2006) The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 27: 208-229.
13. Krishnan R, Park CY, Lin YC, Mead J, Jaspers RT, et al. (2009) Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness. PLoS One 4: e5486.
14. Wu D, Smyth GK, (2012) Camera: a competitive gene set test accounting for inter-gene correlation. Nucleic Acids Res 40: e133.
15. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550.
16. Hakonarson H, Herrick DJ, Serrano PG, Grunstein MM, (1996) Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle. J Clin Invest 97: 2593-2600.
17. Nials AT, Uddin S, (2008) Mouse models of allergic asthma: acute and chronic allergen challenge. Dis Model Mech 1: 213-220.
18. Yawn BP, (2008) Factors accounting for asthma variability: achieving optimal symptom control for individual patients. Prim Care Respir J 17: 138-147.
19. Wu D, Lim E, Vaillant F, Asselin-Labat ML, Visvader JE, et al. (2010) ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics 26: 2176-2182.
20. Yuyama N, Davies DE, Akaiwa M, Matsui K, Hamasaki Y, et al. (2002) Analysis of novel disease-related genes in bronchial asthma. Cytokine 19: 287-296.
21. Gleason NR, Gallos G, Zhang Y, Emala CW, (2009) The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J Appl Physiol 106: 1257-1263.
22. Kendziorski C, Irizarry RA, Chen KS, Haag JD, Gould MN, (2005) On the utility of pooling biological samples in microarray experiments. Proc Natl Acad Sci U S A 102: 4252-4257.
23. Carvalho BS, Irizarry RA, (2010) A framework for oligonucleotide microarray preprocessing. Bioinformatics 26: 2363-2367.
24. Smyth GK, (2004) Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3.
25. Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 57: 289-300.