The spectrum of β-Thalassemia mutations in Baghdad, Central Iraq

Hemoglobin

Volumn 37, Issue 5, 2013, Pages 444-453

  Al Allawi, Nasir A S ^a   Al Mousawi, Bassam M S ^b   Badi, Ameer I A ^a   Jalal, Sana D ^c  

^a UNIVERSITY OF DUHOK   (Iraq)

^b UNIVERSITY OF BAGHDAD   (Iraq)

^c UNIVERSITY OF SULAIMANI   (Iraq)

Author keywords

Thalassemia ( thal); Baghdad; Iraq; IVS I 110 (G>A); IVS II 1 (G>A)

Indexed keywords

HEMOGLOBIN A2; HEMOGLOBIN F;

ADULT; ARTICLE; ASIAN; BETA THALASSEMIA; BLOOD CELL COUNT; CODON; DISEASE CARRIER; DNA HYBRIDIZATION; FEMALE; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENETIC HETEROGENEITY; HEALTH CENTER; HEMOGLOBIN BLOOD LEVEL; HUMAN; INDIAN; IRAQ; MAJOR CLINICAL STUDY; MALE; MULTIPLEX POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; BASE SEQUENCE; BETA-GLOBINS; BETA-THALASSEMIA; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC HETEROGENEITY; HUMANS; IRAQ; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 84883569283     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.3109/03630269.2013.810641     Document Type: Article

References (37)

1. Galanello R, Origa R. β-Thalassemia. Orphanet J Rare Dis. 2010;5:11
2. Yahya HI, Khalel KJ, Al-Allawi NAS, Hilmi F. Thalassaemia genes in Baghdad, Iraq. East Mediterr Health J. 1996;2(2):315-9
3. Hassan MK, Taha JY, Al-Noama LM, Widad NM, Jasim SN. Frequency of hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Basra. East Mediterr Health J. 2003;9(1-2):1-8
4. Al-Allawi NA, Al-Dousky AA. Frequency of haemoglobinopathies at premarital health screening in Dohuk, Iraq: Implications for a regional prevention programme. East Mediterr Health J. 2010;16 (4):381-385
5. Al-Allawi NAS, Jubrael J, Hughson M. Molecular characterization of β-thalassemia in the Dohuk region of Iraq. Hemoglobin. 2006;30(4):479-486
6. Jalal SD, Al-Allawi NAS, Bayat N, Imanian H, Najmabadi H, Faraj A. β-Thalassemia mutations in the Kurdish population of northeastern Iraq. Hemoglobin. 2010;34(5):469-476
7. Al-Allawi NAS, Hassan KMA, Sheikha AK, Nerweiy FF, Dawood RS, Jubrael J. β-Thalassemia mutations among transfusion-dependent thalassemia major patients in northern Iraq. Mol Biol Int. 2010; 2010, Article ID 479282, 4 pages; doi:10.4061/2010/479282
8. www.britannica.com/EBchecked/topic/48773/Baghdad
9. Makhoul NJ, Wells RS, Kaspar H, et al. Genetic heterogeneity of β thalassemia in Lebanon reflects historic and recent population migration. Ann Hum Genet. 2005;69(1):55-66
10. Jiffri EH, Bogari N, Zidan KH, Teama S, Elhawary NA. Molecular updating of β-thalassemia mutations in the upper Egyptian population. Hemoglobin. 2010;34(6):538-547
11. Kyriacou K, Al Quobaili F, Pavlou E, Christopoulos G, Ioannou P, Kleanthous M. Molecular characterization of β-thalassemia in Syria. Hemoglobin. 2000;24(1):1-13
12. Sadiq MF, Eigel A, Horst J. Spectrum of β-thalassemia in Jordan: Identification of two novel mutations. Am J Hematol. 2001;68(1):16-22
13. El-Hazmi MA, Al-Swailem AR, Warsy AS. Molecular defects in β-thalassaemias in the population of Saudi Arabia. Hum Hered. 1995;45(5):278-285
14. Altay Ç. The frequency and distribution pattern of β-thalassemia mutations in Turkey. Turk J Haematol. 2002;19(2):309-315
15. Baysal E, Indrak K, Bozkurt G, et al. The β-thalassaemia mutations in the population of Cyprus. Br J Haematol. 1992;81(4):607-609
16. Kattamis C, Hu H, Cheng G, et al. Molecular characterization of β-thalassaemia in 174 Greek patients with thalassaemia major. Br J Haematol. 1990;74(3):342-346
17. Flint J, Harding RM, Clegg JB, Boyce AJ. Why are some genetic diseases commoñDistinguishing selection from other processes by molecular analysis of globin gene variants. Hum Genet. 1993;91 (2):91-117
18. Tadmouri GO, Garguier N, Demont J, Perrin P, Başak AN. History and origin of β-thalassemia in Turkey: Sequence haplotype diversity of the β-globin gene. Hum Biol. 2001;73(5):661-674
19. Najmabadi H, Karimi-Nejad R, Sahebjam S, Pourfarzad F, Teimourian S, Sahebjam F. The β-thalassemia mutation spectrum in the Iranian population. Hemoglobin. 2001;25(3):285-96
20. Baysal E. Molecular basis of β-thalassemia in the United Arab Emirates. Hemoglobin. 2011;35 (6):581-588
21. Jassim N, Merghoub T, Pascaud O, et al. Molecular basis of β-thalassemia in Bahrain: An epicenter for a Middle East specific mutation. Ann NY Acad Sci. 1998;850:407-409.
22. Al-Sultan A, Phanasgaonkar S, Suliman A, Al-Baqushi M, Nasrullah Z, Al-Ali A. Spectrum of β-thalassemia mutations in the eastern province of Saudi Arabia. Hemoglobin. 2011;35(2):125-134
23. Hassan SM, Hamza N, Al-Lawatiya FJ, et al. Extended molecular spectrum of β- And α-thalasemia in Oman. Hemoglobin. 2010;34(2):127-134
24. Adekile AD, Gu L-H, Baysal E, et al. Molecular characterization of α-thalassemia determinants, β-thalassemia alleles, and βS haplotypes among Kuwaiti Arabs. Acta Haematol. 1994;92(4):176-181
25. Rund D, Cohen T, Filon D, et al. Evolution of a genetic disease in an ethnic isolate: β-thalassemia in the Jews of Kurdistan. Proc Natl Acad Sci USA. 1991;88(1):310-314
26. Hussein IR, Temtamy SA, El-Beshlawy A, et al. Molecular characterization of β-thalassemia in Egyptians. Hum Mutat. 1993;2(1):48-52
27. Abuzenadah AM, Hussein IMR, Damanhouri GA, et al. Molecular basis of β-thalassemia in the western province of Saudi Arabia: Identification of rare β-thalassemia mutation. Hemoglobin. 2011;35(4):346-357
28. Henderson S, Timbs A, McCarthy J, et al. Incidence of haemoglobinopathies in various populations - The impact of immigration. Clin Biochem. 2009;42(8):1745-1756
29. Wong C, Antonarakis SE, Goff SE, et al. β-Thalassemia due to two novel nucleotide substitutions in the consensus acceptor splice sequences of the β-globin gene. Blood. 1989;73(4): 914-918
30. Haghi M, Khorshidi S, Hosseinpour Feizi MA, Pouladi N, Hosseinpour Feizi AA. β-Thalassemia mutations in the Kurdish population of Kurdistan and West Azerbaijan provinces. Hemoglobin. 2009;33(2):109-114
31. Boudrahem-Addour N, Zidani N, Carion N, Labie D, Belhani M, Beldjord C. Molecular heterogeneity of β-thalassemia in Algeria: How to face up to a major health problem. Hemoglobin. 2009;33(1):24-36
32. Hardison RC, Chui DHK, Giardine B, et al. HbVar: A relational database of human hemoglobin variants and thalassemia mutations at the globin gene server. Hum Mutat. 2002;19(3):225-233 (http://globin. cse.psu.edu).
33. Patrinos GP, Giardine B, Riemer C, et al. Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies. Nucleic Acids Res. 2004;32(Database issue):D537-D541 (http://globin.cse.psu.edu).
34. Weatherall DJ, Clegg JB. The Thalassaemia Syndromes, 4th ed. Oxford: Blackwell Science, 2001
35. Kutlar A, Kutlar F, Gu L-G, Mayson SM, Huisman THJ. Fetal hemoglobin in normal adults and β- Thalassemia heterozygotes. Hum Genet. 1990;85(1):106-110
36. Öner R, Altay Ç, Gurgey A, et al. β-thalassemia in Turkey. Hemoglobin. 1990;14(1):1-13
37. Vrettou C, Kanavakis E, Traeger-Synodinos J, et al. Molecular basis of β-thalassemia with raised Hb F levels. Hemoglobin. 2000;24(3):203-220.