Percutaneous autologous bone marrow injection in the treatment of distal meta-diaphyseal tibial nonunions and delayed unions

Journal of Orthopaedic Trauma

Volumn 27, Issue 9, 2013, Pages 527-533

  Braly, Houston L ^a   O'Connor, Daniel P ^b   Brinker, Mark R ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

Autologous; Bone marrow; Fracture; Nonunion or delayed union; Open reduction and internal fixation; Percutaneous injections; Ununited

Indexed keywords

ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW; BONE MARROW BIOPSY; BRIEF PAIN INVENTORY; CLINICAL ARTICLE; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; DISTAL TIBIA FRACTURE; FEMALE; FRACTURE HEALING; FRACTURE NONUNION; HUMAN; ILIAC CREST; MALE; METAPHYSIS; OPEN REDUCTION; OSTEOBLAST; OSTEOSYNTHESIS; PAIN ASSESSMENT; PLATE FIXATION; PRIORITY JOURNAL; PSEUDARTHROSIS; QUALITY ADJUSTED LIFE YEAR; SHORT FORM 12; TERTIARY HEALTH CARE;

ADMINISTRATION, CUTANEOUS; ADULT; AUTOGRAFTS; BONE MARROW TRANSPLANTATION; DIAPHYSES; FEMALE; FOLLOW-UP STUDIES; FRACTURE FIXATION, INTERNAL; FRACTURE HEALING; FRACTURES, UNUNITED; HUMANS; INJECTIONS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TIBIAL FRACTURES; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84883557381     PISSN: 08905339     EISSN: 15312291     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31828bf077     Document Type: Article

References (44)

1. Brinker MR, O'Connor DP. Nonunions: Evaluation and treatment. In: Browner BD, Jupiter JB, Levine AM, Trafton PG, eds. Skeletal Trauma: Basic Science, Management, and Reconstruction. 4th ed. Philadelphia, PA: W.B. Saunders; 2009:615-708
2. Lonner JH, Koval KJ, Golyakhovsky V, et al. Posttraumatic nonunion of the distal tibial metaphysis. Treatment using the Ilizarov circular external fixator. Am J Orthop. 1995;24(suppl):16-21
3. Richmond J, Colleran K, Borens O, et al. Nonunions of the distal tibia treated by reamed intramedullary nailing. J Orthop Trauma. 2004;18:603-610
4. Hernigou P, Poignard A, Beaujean F, et al. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am. 2005;87:1430-1437
5. Hernigou P, Poignard A, Manicom O, et al. The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone. J Bone Joint Surg Br. 2005;87:896-902
6. Paley D, Young MC, Wiley AM, et al. Percutaneous bone marrow grafting of fractures and bony defects. An experimental study in rabbits. Clin Orthop Relat Res. 1986;208:300-312
7. Tiedeman JJ, Connolly JF, Strates BS, et al. Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs. Clin Orthop Relat Res. 1991;268:294-302
8. Richards M, Huibregtse BA, Caplan AI, et al. Marrow-derived progenitor cell injections enhance new bone formation during distraction. J Orthop Res. 1999;17:900-908
9. Goel A, Sangwan SS, Siwach RC, et al. Percutaneous bone marrow grafting for the treatment of tibial non-union. Injury. 2005;36:203-206
10. Bhargava R, Sankhla S, Gupta A, et al. Percutaneous autologus bone marrow injection in the treatment of delayed or nonunion. Indian J Orthop. 2007;41:67-71
11. Seitz WH Jr, Froimson AI, Leb RB. Autogenous bone marrow and allograft replacement of bone defects in the hand and upper extremities. J Orthop Trauma. 1992;6:36-42
12. Matsuda Y, Sakayama K, Okumura H, et al. Percutaneous autologous bone marrow transplantation for nonunion of the femur. Nippon Geka Hokan. 1998;67:10-17
13. Connolly JF, Shindell R. Percutaneous marrow injection for an ununited tibia. Nebr Med J. 1986;71:105-107
14. Connolly JF. Injectable bone marrow preparations to stimulate osteogenic repair. Clin Orthop Relat Res. 1995;313:8-18
15. Garg NK, Gaur S, Sharma S. Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture. Acta Orthop Scand. 1993;64:671-672
16. Sim R, Liang TS, Tay BK. Autologous marrow injection in the treatment of delayed and non-union in long bones. Singapore Med J. 1993;34:412-417
17. Siwach RC, Sangwan SS, Singh R, et al. Role of percutaneous bone marrow grafting in delayed unions, non-unions and poor regenerates. Indian J Med Sci. 2001;55:326-336
18. Wilkins RM, Chimenti BT, Rifkin RM. Percutaneous treatment of long bone nonunions: The use of autologous bone marrow and allograft bone matrix. Orthopedics. 2003;26(suppl):s549-s554
19. Connolly JF, Guse R, Tiedeman J, et al. Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop Relat Res. 1991;266:259-270
20. Haverstock BD, Mandracchia VJ. Cigarette smoking and bone healing: Implications in foot and ankle surgery. J Foot Ankle Surg. 1998;37:69-74
21. Taylor JC. Delayed union and nonunion of fractures. In: Crenshaw AH, ed. Campbell's Operative Orthopaedics. 8th ed. St Louis, MO: Mosby; 1992:1287-1345
22. Müller ME, Allgöwer M, Schneider R, eds. Manual of Internal Fixation: Techniques Recommended by the AO Group. 2nd ed. Berlin, Germany: Springer-Verlag; 1979
23. Muschler GF, Boehm C, Easley K. Aspiration to obtain osteoblast progenitor cells from human bone marrow: The influence of aspiration volume. J Bone Joint Surg Am. 1997;79:1699-1709
24. Heckman JD, Ryaby JP, McCabe J, et al. Acceleration of tibial fracturehealing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg Am. 1994;76:26-34
25. Johanson NA, Liang MH, Daltroy L, et al. American Academy of Orthopaedic Surgeons lower limb outcomes assessment instruments. Reliability, validity, and sensitivity to change. J Bone Joint Surg Am. 2004;86:902-909
26. Daut RL, Cleeland CS, Flanery RC. Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases. Pain. 1983;17:197-210
27. Ware JE Jr, Kosinski M, Keller SD. SF-12: How to Score the SF-12 Physical and Mental Health Summary Scales. Boston, MA: The Health Institute, New England Medical Center; 1995
28. Ware JE Jr, Kosinski M, Keller SD. A 12-item short-form health survey: Construction of scales and preliminary tests of reliabilty and validity. Med Care. 1996;34:220-233
29. Torrance GW. Utility approach to measuring health-related quality of life. J Chronic Dis. 1987;40:593-603
30. Arias E. United States life tables, 2002. Natl Vital Stat Rep. 2004;53:1-38
31. Reed LK, Mormino MA. Functional outcome after blade plate reconstruction of distal tibia metaphyseal nonunions: A study of 11 cases. J Orthop Trauma. 2004;18:81-86
32. Reed LK, Mormino MA. Distal tibia nonunions. Foot Ankle Clin. 2008;13:725-735
33. Carpenter CA, Jupiter JB. Blade plate reconstruction of metaphyseal nonunion of the tibia. Clin Orthop Relat Res. 1996;332:23-28
34. Chin KR, Nagarkatti DG, Miranda MA, et al. Salvage of distal tibia metaphyseal nonunions with the 90 degrees cannulated blade plate. Clin Orthop Relat Res. 2003;409:241-249
35. Harvey EJ, Henley MB, Swiontkowski MF, et al. The use of a locking custom contoured blade plate for peri-Articular nonunions. Injury. 2003;34:111-116
36. Hutson JJ Jr. Salvage of pilon fracture nonunion and infection with circular tensioned wire fixation. Foot Ankle Clin. 2008;13:29-68, vi
37. Bedi A, Le TT, Karunakar MA. Surgical treatment of nonarticular distal tibia fractures. J Am Acad Orthop Surg. 2006;14:406-416
38. Ryzewicz M, Morgan SJ, Linford E, et al. Central bone grafting for nonunion of fractures of the tibia: A retrospective series. J Bone Joint Surg Br. 2009;91:522-529
39. Cavadas PC, Landin L. Treatment of recalcitrant distal tibial nonunion using the descending genicular corticoperiosteal free flap. J Trauma. 2008;64:144-150
40. Wu CC. Single-stage surgical treatment of infected nonunion of the distal tibia. J Orthop Trauma. 2011;25:156-161
41. Wu CC, Shih CH. Distal tibial nonunion treated by intramedullary reaming with external immobilization. J Orthop Trauma. 1996;10:45-49
42. Garnavos C, Mouzopoulos G, Morakis E. Fixed intramedullary nailing and percutaneous autologous concentrated bone-marrow grafting can promote bone healing in humeral-shaft fractures with delayed union. Injury. 2010;41:563-567
43. Watson JT, Quigley KJ, Mudd CD. Percutaneous injection of iliac crest aspirate for the treatment of long bone delayed union and nonunion [abstract]. October 4, 2006. Available at: Http://www.hwbf.org/ota/am/ ota06/otapa/ OTA060313.htm. Accessed August 8, 2012
44. Hernigou P, Mathieu G, Poignard A, et al. Percutaneous autologous bone-marrow grafting for nonunions. Surgical technique. J Bone Joint Surg Am. 2006;88(suppl 1 Pt 2):322-327