Impact of older age and nursing home residence on clinical outcomes of US emergency department visits for severe sepsis

Journal of Critical Care

Volumn 28, Issue 5, 2013, Pages 606-611

  Ginde, Adit A ^a   Moss, Marc ^a   Shapiro, Nathan I ^b   Schwartz, Robert S ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Critical care; Emergency medicine; Epidemiology; Geriatrics; Infection; Nursing home; Organ failure; Sepsis

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; GERIATRIC CARE; GERIATRIC PATIENT; HOSPITALIZATION; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; NURSING HOME; NURSING HOME PATIENT; RETROSPECTIVE STUDY; SEPSIS; UNITED STATES;

CRITICAL CARE; EMERGENCY MEDICINE; EPIDEMIOLOGY; GERIATRICS; INFECTION; NURSING HOME; ORGAN FAILURE; SEPSIS;

AGE FACTORS; AGED; AGED, 80 AND OVER; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITAL MORTALITY; HUMANS; INCIDENCE; LENGTH OF STAY; MALE; MIDDLE AGED; NURSING HOMES; RETROSPECTIVE STUDIES; SEPSIS; UNITED STATES;

EID: 84883550855     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2013.03.018     Document Type: Article

References (26)

1. Angus D.C., Linde-Zwirble W.T., Lidicker J., et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310.
2. Martin G.S., Mannino D.M., Eaton S., et al. The epidemiology of sepsis in the United States from 1979 to 2000. N Engl J Med 2003, 348:1546-1554.
3. Rivers E., Nguyen B., Havstad S., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377.
4. Dellinger R.P., Levy M.M., Carlet J.M., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36:296-327.
5. Weycker D., Akhras K.S., Edelsberg J., et al. Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med 2003, 31:2316-2323.
6. Wheeler A.P., Bernard G.R. Treating patients with severe sepsis. N Engl J Med 1999, 340:207-214.
7. Martin G.S., Mannino D.M., Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med 2006, 34:15-21.
8. Strehlow M.C., Emond S.D., Shapiro N.I., et al. National study of emergency department visits for sepsis: 1992-2001. Ann Emerg Med 2006, 48:326-331.
9. Wang H.E., Shapiro N.I., Angus D.C., et al. National estimates of severe sepsis in United States emergency departments. Crit Care Med 2007, 35:1928-1936.
10. National Center for Health Statistics Ambulatory health care data Available at:, Accessed June 11, 2012. http://www.cdc.gov/nchs/ahcd.htm.
11. The International Classification of Diseases, 9th revision. Clinical Modification 1997, National Center for Health Statistics, Medicode Publications, Salt Lake City (Utah). 5th ed.
12. Levy M.M., Fink M.P., Marshall J.C., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Intensive Care Med 2003, 29:530-538.
13. Danai P.A., Sinha S., Moss M., et al. Seasonal variation in the epidemiology of sepsis. Crit Care Med 2007, 35:410-415.
14. Caterino J.M., Ting S.A., Sisbarro S.G., et al. Age, nursing home residence, and presentation of urinary tract infection in U.S. emergency departments, 2001-2008. Acad Emerg Med 2012, 19:1173-1180.
15. Agarwal S., Busse P.J. Innate and adaptive immunosenescence. Ann Allergy Asthma Immunol 2010, 104:183-190.
16. Kumar R., Burns E.A. Age-related decline in immunity: implications for vaccine responsiveness. Exper Rev Vaccines 2008, 7:467-479.
17. Opal S.M., Girard T.D., Ely E.W. The immunopathogenesis of sepsis in elderly patients. Clin Infect Dis 2005, 41:S504-S512.
18. DeGaudio E.R., Rinaldi S., Chelazzi C., et al. Pathophysiology of sepsis in the elderly: clinical impact and therapeutic considerations. Curr Drug Targets 2009, 10:60-70.
19. Van Buul L.W., van der Steen J.T., Veenhuizen R.B., et al. Antibiotic use and resistance in long-term care facilities. J Am Med Dir Assoc 2012, 13:568.e1-568.e13.
20. Landi F., Liperoti R., Fusco D., et al. Prevalence and risk factors of sarcopenia among nursing home older residents. J Gerontol A Biol Med Sci 2012, 67:48-55.
21. Lee P.G., Cigolle C., Blaum C. The co-occurrence of chronic diseases and geriatrics syndromes: the Health and Retirement Study. J Am Geriatr Soc 2009, 57:511-516.
22. Li H., Manwani B., Leng S.X. Frailty, inflammation, and immunity. Aging Dis 2011, 2:466-473.
23. Graverholt B., Riise T., Jamtvedt G., et al. Acute hospital admissions among nursing home residents: a population-based observational study. BMC Health Serv Res 2011, 11:126.
24. Iwashyna T.J., Cooke C.R., Wunsch H., et al. Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc 2012, 60:1070-1077.
25. Iwashyna T.J., Ely E.W., Smith D.M., et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010, 304:1787-1794.
26. Rajapakse S., Rajapakse A. Age bias in clinical trials in sepsis: how relevant are guidelines to older people?. J Crit Care 2009, 24:609-613.