메뉴 건너뛰기




Volumn 43, Issue 9, 2013, Pages 2263-2272

In vivo activation of transferred regulatory T cells specific for third-party exogenous antigen controls GVH disease in mice

Author keywords

GVH disease; Immune regulation; Inducible activation of regulatory T (Treg) cells; Tolerance; Transplantation

Indexed keywords

ANTIGEN;

EID: 84883528115     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343449     Document Type: Article
Times cited : (11)

References (45)
  • 3
    • 0030801512 scopus 로고    scopus 로고
    • Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immunotherapy
    • Mackall, C. L. and Gress, R. E., Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immunotherapy. Immunol. Rev. 1997. 157: 61-72.
    • (1997) Immunol. Rev. , vol.157 , pp. 61-72
    • Mackall, C.L.1    Gress, R.E.2
  • 5
    • 77649163290 scopus 로고    scopus 로고
    • Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1
    • Amarnath, S., Costanzo, C. M., Mariotti, J., Ullman, J. L., Telford, W. G., Kapoor, V., Riley, J. L. et al., Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1. PLoS Biol. 2010. 8: e1000302.
    • (2010) PLoS Biol. , vol.8
    • Amarnath, S.1    Costanzo, C.M.2    Mariotti, J.3    Ullman, J.L.4    Telford, W.G.5    Kapoor, V.6    Riley, J.L.7
  • 7
    • 0032188990 scopus 로고    scopus 로고
    • Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation
    • Ratanatharathorn, V., Nash, R. A., Przepiorka, D., Devine, S. M., Klein, J. L., Weisdorf, D., Fay, J. W. et al., Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation. Blood 1998. 92: 2303-2314.
    • (1998) Blood , vol.92 , pp. 2303-2314
    • Ratanatharathorn, V.1    Nash, R.A.2    Przepiorka, D.3    Devine, S.M.4    Klein, J.L.5    Weisdorf, D.6    Fay, J.W.7
  • 8
    • 0024510510 scopus 로고
    • Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial
    • Storb, R., Deeg, H. J., Pepe, M., Appelbaum, F., Anasetti, C., Beatty, P., Bensinger, W., et al., Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial. Blood 1989. 73: 1729-1734.
    • (1989) Blood , vol.73 , pp. 1729-1734
    • Storb, R.1    Deeg, H.J.2    Pepe, M.3    Appelbaum, F.4    Anasetti, C.5    Beatty, P.6    Bensinger, W.7
  • 9
    • 36348990261 scopus 로고    scopus 로고
    • Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study
    • Bhatia, S., Francisco, L., Carter, A., Sun, C. L., Baker, K. S., Gurney, J. G., McGlave, P. B. et al., Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study. Blood 2007. 110: 3784-3792.
    • (2007) Blood , vol.110 , pp. 3784-3792
    • Bhatia, S.1    Francisco, L.2    Carter, A.3    Sun, C.L.4    Baker, K.S.5    Gurney, J.G.6    McGlave, P.B.7
  • 10
    • 0033168009 scopus 로고    scopus 로고
    • Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry
    • Socie, G., Stone, J. V., Wingard, J. R., Weisdorf, D., Henslee-Downey, P. J., Bredeson, C., Cahn, J. Y. et al., Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N. Engl. J. Med. 1999. 341: 14-21.
    • (1999) N. Engl. J. Med. , vol.341 , pp. 14-21
    • Socie, G.1    Stone, J.V.2    Wingard, J.R.3    Weisdorf, D.4    Henslee-Downey, P.J.5    Bredeson, C.6    Cahn, J.Y.7
  • 11
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor, P. A., Lees, C. J. and Blazar, B. R., The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002. 99: 3493-3499.
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 12
    • 0037026001 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease
    • Cohen, J. L., Trenado, A., Vasey, D., Klatzmann, D. and Salomon, B. L., CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 2002. 196: 401-406.
    • (2002) J. Exp. Med. , vol.196 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 13
    • 0346690399 scopus 로고    scopus 로고
    • Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
    • Trenado, A., Charlotte, F., Fisson, S., Yagello, M., Klatzmann, D., Salomon, B. L. and Cohen, J. L., Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J. Clin. Invest. 2003. 112: 1688-1696.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3    Yagello, M.4    Klatzmann, D.5    Salomon, B.L.6    Cohen, J.L.7
  • 14
    • 9444280125 scopus 로고    scopus 로고
    • L-Selectin(hi) but not the L-selectin(lo) CD4+25 +T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
    • Taylor, P. A., Panoskaltsis-Mortari, A., Swedin, J. M., Lucas, P. J., Gress, R. E., Levine, B. L., June, C. H. et al., L-Selectin(hi) but not the L-selectin(lo) CD4+25 +T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 2004. 104: 3804-3812.
    • (2004) Blood , vol.104 , pp. 3804-3812
    • Taylor, P.A.1    Panoskaltsis-Mortari, A.2    Swedin, J.M.3    Lucas, P.J.4    Gress, R.E.5    Levine, B.L.6    June, C.H.7
  • 15
    • 14944346738 scopus 로고    scopus 로고
    • Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    • Ermann, J., Hoffmann, P., Edinger, M., Dutt, S., Blankenberg, F. G., Higgins, J. P., Negrin, R. S. et al., Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 2005. 105: 2220-2226.
    • (2005) Blood , vol.105 , pp. 2220-2226
    • Ermann, J.1    Hoffmann, P.2    Edinger, M.3    Dutt, S.4    Blankenberg, F.G.5    Higgins, J.P.6    Negrin, R.S.7
  • 16
    • 30744461834 scopus 로고    scopus 로고
    • Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells
    • Trenado, A., Sudres, M., Tang, Q., Maury, S., Charlotte, F., Gregoire, S., Bonyhadi, M. et al., Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. J. Immunol. 2006. 176: 1266-1273.
    • (2006) J. Immunol. , vol.176 , pp. 1266-1273
    • Trenado, A.1    Sudres, M.2    Tang, Q.3    Maury, S.4    Charlotte, F.5    Gregoire, S.6    Bonyhadi, M.7
  • 17
    • 84871300084 scopus 로고    scopus 로고
    • Alloantigen-specific regulatory T cells prevent experimental chronic graft-versus-host disease by simultaneous control of allo- and autoreactivity
    • Sagoo, P., Ratnasothy, K., Tsang, Y., Barber, L. D., Noble, A., Lechler, R. I. and Lombardi, G., Alloantigen-specific regulatory T cells prevent experimental chronic graft-versus-host disease by simultaneous control of allo- and autoreactivity. Eur. J. Immunol. 2012. 42: 3322-3333.
    • (2012) Eur. J. Immunol. , vol.42 , pp. 3322-3333
    • Sagoo, P.1    Ratnasothy, K.2    Tsang, Y.3    Barber, L.D.4    Noble, A.5    Lechler, R.I.6    Lombardi, G.7
  • 18
  • 19
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    • Brunstein, C. G., Miller, J. S., Cao, Q., McKenna, D. H., Hippen, K. L., Curtsinger, J., Defort, T. et al., Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011. 117: 1061-1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3    McKenna, D.H.4    Hippen, K.L.5    Curtsinger, J.6    Defort, T.7
  • 20
    • 79956288367 scopus 로고    scopus 로고
    • Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells
    • Sagoo, P., Ali, N., Garg, G., Nestle, F. O., Lechler, R. I. and Lombardi, G., Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci. Transl. Med. 2011. 3: 83ra42.
    • (2011) Sci. Transl. Med. , vol.3
    • Sagoo, P.1    Ali, N.2    Garg, G.3    Nestle, F.O.4    Lechler, R.I.5    Lombardi, G.6
  • 21
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang, Q., Henriksen, K. J., Bi, M., Finger, E. B., Szot, G., Ye, J., Masteller, E. L. et al., In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 2004. 199: 1455-1465.
    • (2004) J. Exp. Med. , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5    Ye, J.6    Masteller, E.L.7
  • 22
    • 2942692039 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • Tarbell, K. V., Yamazaki, S., Olson, K., Toy, P. and Steinman, R. M., CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 2004. 199: 1467-1477.
    • (2004) J. Exp. Med. , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 23
    • 79953093078 scopus 로고    scopus 로고
    • Immune reconstitution is preserved in hematopoietic stem cell transplant co-administered with regulatory T cells for GVHD prevention
    • Gaidot, A., Landau, D. A., Martin, G. H., Bonduelle, O., Grinberg-Bleyer, Y., Matheoud, D., Gregoire, S. et al., Immune reconstitution is preserved in hematopoietic stem cell transplant co-administered with regulatory T cells for GVHD prevention. Blood 2011. 117: 2975-2983.
    • (2011) Blood , vol.117 , pp. 2975-2983
    • Gaidot, A.1    Landau, D.A.2    Martin, G.H.3    Bonduelle, O.4    Grinberg-Bleyer, Y.5    Matheoud, D.6    Gregoire, S.7
  • 24
    • 32644486426 scopus 로고    scopus 로고
    • Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire
    • Fisson, S., Djelti, F., Trenado, A., Billiard, F., Liblau, R., Klatzmann, D., Cohen, J. L. et al., Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire. Eur. J. Immunol. 2006. 36: 817-827.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 817-827
    • Fisson, S.1    Djelti, F.2    Trenado, A.3    Billiard, F.4    Liblau, R.5    Klatzmann, D.6    Cohen, J.L.7
  • 25
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
    • Tang, Q. and Bluestone, J. A., The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 2008. 9: 239-244.
    • (2008) Nat. Immunol. , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 26
    • 70249143637 scopus 로고    scopus 로고
    • Homeostatic proliferation and survival of naive and memory T cells
    • Boyman, O., Letourneau, S., Krieg, C. and Sprent, J., Homeostatic proliferation and survival of naive and memory T cells. Eur. J. Immunol. 2009. 39: 2088-2094.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2088-2094
    • Boyman, O.1    Letourneau, S.2    Krieg, C.3    Sprent, J.4
  • 27
    • 84860330192 scopus 로고    scopus 로고
    • Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T-cell clonal deletion and suppressing NK cell function
    • Su, Y., Huang, X., Wang, S., Min, W. P., Yin, Z., Jevnikar, A. M. and Zhang, Z. X., Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T-cell clonal deletion and suppressing NK cell function. Eur. J. Immunol. 2012. 42: 1216-1225.
    • (2012) Eur. J. Immunol. , vol.42 , pp. 1216-1225
    • Su, Y.1    Huang, X.2    Wang, S.3    Min, W.P.4    Yin, Z.5    Jevnikar, A.M.6    Zhang, Z.X.7
  • 28
    • 0033985780 scopus 로고    scopus 로고
    • Suppressor effector function of CD4+CD25+immunoregulatory T cells is antigen nonspecific
    • Thornton, A. M. and Shevach, E. M., Suppressor effector function of CD4+CD25+immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000. 164: 183-190.
    • (2000) J. Immunol. , vol.164 , pp. 183-190
    • Thornton, A.M.1    Shevach, E.M.2
  • 29
    • 0035892115 scopus 로고    scopus 로고
    • Division rate and phenotypic differences discriminate alloreactive and nonalloreactive T cells transferred in lethally irradiated mice
    • Maury, S., Salomon, B., Klatzmann, D. and Cohen, J. L., Division rate and phenotypic differences discriminate alloreactive and nonalloreactive T cells transferred in lethally irradiated mice. Blood 2001. 98: 3156-3158.
    • (2001) Blood , vol.98 , pp. 3156-3158
    • Maury, S.1    Salomon, B.2    Klatzmann, D.3    Cohen, J.L.4
  • 30
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz, J. D., Wang, B., Haskins, K., Benoist, C. and Mathis, D., Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993. 74: 1089-1100.
    • (1993) Cell , vol.74 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 31
    • 65449122461 scopus 로고    scopus 로고
    • Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg
    • Stephens, L. A., Malpass, K. H. and Anderton, S. M., Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg. Eur. J. Immunol. 2009. 39: 1108-1117.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1108-1117
    • Stephens, L.A.1    Malpass, K.H.2    Anderton, S.M.3
  • 33
    • 14844352743 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation
    • Karim, M., Feng, G., Wood, K. J. and Bushell, A. R., CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation. Blood 2005. 105: 4871-4877.
    • (2005) Blood , vol.105 , pp. 4871-4877
    • Karim, M.1    Feng, G.2    Wood, K.J.3    Bushell, A.R.4
  • 34
    • 42149141724 scopus 로고    scopus 로고
    • Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression
    • Verginis, P., McLaughlin, K. A., Wucherpfennig, K. W., von Boehmer, H. and Apostolou, I., Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc. Natl. Acad. Sci. USA 2008. 105: 3479-3484.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 3479-3484
    • Verginis, P.1    McLaughlin, K.A.2    Wucherpfennig, K.W.3    von Boehmer, H.4    Apostolou, I.5
  • 35
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells
    • Hoffmann, P., Eder, R., Kunz-Schughart, L. A., Andreesen, R. and Edinger, M., Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 2004. 104: 895-903.
    • (2004) Blood , vol.104 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3    Andreesen, R.4    Edinger, M.5
  • 37
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann, P., Eder, R., Boeld, T. J., Doser, K., Piseshka, B., Andreesen, R. and Edinger, M., Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006. 108: 4260-4267.
    • (2006) Blood , vol.108 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3    Doser, K.4    Piseshka, B.5    Andreesen, R.6    Edinger, M.7
  • 38
    • 34547214205 scopus 로고    scopus 로고
    • Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    • Roncarolo, M. G. and Battaglia, M., Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat. Rev. Immunol. 2007. 7: 585-598.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 585-598
    • Roncarolo, M.G.1    Battaglia, M.2
  • 39
    • 65449141433 scopus 로고    scopus 로고
    • Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
    • Hoffmann, P., Boeld, T. J., Eder, R., Huehn, J., Floess, S., Wieczorek, G., Olek, S. et al., Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur. J. Immunol. 2009. 39: 1088-1097.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1088-1097
    • Hoffmann, P.1    Boeld, T.J.2    Eder, R.3    Huehn, J.4    Floess, S.5    Wieczorek, G.6    Olek, S.7
  • 40
    • 77954539326 scopus 로고    scopus 로고
    • In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    • Nadig, S. N., Wieckiewicz, J., Wu, D. C., Warnecke, G., Zhang, W., Luo, S., Schiopu, A. et al., In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat. Med. 2010. 16: 809-813.
    • (2010) Nat. Med. , vol.16 , pp. 809-813
    • Nadig, S.N.1    Wieckiewicz, J.2    Wu, D.C.3    Warnecke, G.4    Zhang, W.5    Luo, S.6    Schiopu, A.7
  • 41
    • 79954504851 scopus 로고    scopus 로고
    • Clinical tolerance in allogeneic hematopoietic stem cell transplantation
    • Roncarolo, M. G., Gregori, S., Lucarelli, B., Ciceri, F. and Bacchetta, R., Clinical tolerance in allogeneic hematopoietic stem cell transplantation. Immunol. Rev. 2011. 241: 145-163.
    • (2011) Immunol. Rev. , vol.241 , pp. 145-163
    • Roncarolo, M.G.1    Gregori, S.2    Lucarelli, B.3    Ciceri, F.4    Bacchetta, R.5
  • 43
    • 79956258982 scopus 로고    scopus 로고
    • Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity
    • Hippen, K. L., Merkel, S. C., Schirm, D. K., Sieben, C. M., Sumstad, D., Kadidlo, D. M., McKenna, D. H. et al., Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity. Sci. Transl. Med. 2011. 3: 83ra41.
    • (2011) Sci. Transl. Med. , vol.3
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3    Sieben, C.M.4    Sumstad, D.5    Kadidlo, D.M.6    McKenna, D.H.7
  • 44
    • 80053597291 scopus 로고    scopus 로고
    • Regulatory T cells in stem cell transplantation: strategies and first clinical experiences
    • Edinger, M. and Hoffmann, P., Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. Curr. Opin. Immunol. 2011. 23: 679-684.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 679-684
    • Edinger, M.1    Hoffmann, P.2
  • 45
    • 0034193057 scopus 로고    scopus 로고
    • The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation
    • Hill, G. R. and Ferrara, J. L., The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 2000. 95: 2754-2759.
    • (2000) Blood , vol.95 , pp. 2754-2759
    • Hill, G.R.1    Ferrara, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.