A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells

Brazilian Journal of Medical and Biological Research

Volumn 46, Issue 8, 2013, Pages 643-649

  Chen, C ^a   Yang, R L ^b  

^a HEBEI UNIVERSITY   (China)

^b Key Laboratory of Farmland Ecological and Environment of Hebei Province   (China)

Author keywords

Apoptosis; MP 4 (3 ,3 dimethylallyloxy) 5 methyl 6 methoxyphthalide ; p73

Indexed keywords

BIM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PHTHALIDE DERIVATIVE; PROTEIN P21; PROTEIN P27; PROTEIN P73; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG; [4 (39,39 DIMETHYLALLYLOXY) 5 METHYL 6 METHOXYPHTHALIDE];

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA FRAGMENTATION; FLOW CYTOMETRY; FUNGUS; G1 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; PESTALOTIOPSIS PHOTINIAE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

FUNGI; PESTALOTIOPSIS PHOTINIAE; PODOCARPACEAE; PODOCARPUS MACROPHYLLUS;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZOFURANS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA-BINDING PROTEINS; ENDOPHYTES; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; G1 PHASE CELL CYCLE CHECKPOINTS; GENES, P16; GYMNOSPERMS; HELA CELLS; HUMANS; NUCLEAR PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; XYLARIALES;

EID: 84883511451     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20132979     Document Type: Article

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