Non-dioxin-like PCBs inhibit [3H]WIN-35,428 binding to the dopamine transporter: A structure-activity relationship study

NeuroToxicology

Volumn 39, Issue , 2013, Pages 18-24

  Wigestrand, M B ^a   Stenberg, M ^b   Walaas, S I ^a   Fonnum, F ^a   Andersson, P L ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

DAT; Dopamine; PCB; Structure activity; Toxicity; WIN 35,428

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; AROCLOR; COCAINE; DOPAMINE TRANSPORTER; NON DIOXIN LIKE POLYCHLORINATED BIPHENYL; POLYCHLORINATED BIPHENYL; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2;

ARTICLE; BEHAVIOR; BINDING ASSAY; CHEMICAL STRUCTURE; CHLORINATION; CONCENTRATION (PARAMETERS); DOSE RESPONSE; DRUG POTENCY; IC 50; MALE; NEUROTOXICITY; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; STRUCTURE ACTIVITY RELATION; SYNAPTOSOME; TRAINING;

DAT; DIOXIN-LIKE PCB; DL-PCB; DOPAMINE; DOPAMINE TRANSPORTER; NDL-PCB; NON-DIOXIN-LIKE PCB; PARTIAL LEAST SQUARES; PCA; PCB; PKC; PLS; POLYCHLORINATED BIPHENYL; PRINCIPAL COMPONENT ANALYSIS; PROTEIN KINASE C; QSAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SAR; STRUCTURE-ACTIVITY; STRUCTURE-ACTIVITY RELATIONSHIP; TEF; TOXIC EQUIVALENT FACTORS; TOXICITY; ULTRAVIOLET; UV; VESICULAR MONOAMINE TRANSPORTER 2; VMAT2; WIN-35,428;

ANIMALS; COCAINE; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; INHIBITORY CONCENTRATION 50; MALE; MODELS, CHEMICAL; POLYCHLORINATED BIPHENYLS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES; TRITIUM;

EID: 84883499999     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.07.005     Document Type: Article

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