Do we know when to treat neonatal thrombocytopaenia?

Archives of Disease in Childhood: Fetal and Neonatal Edition

Volumn 98, Issue 5, 2013, Pages

  Venkatesh, Vidheya ^a   Curley, Anna E ^a   Clarke, Paul ^b   Watts, Timothy ^c   Stanworth, Simon J ^d  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^d OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; ROMIPLOSTIM; THROMBOPLASTIN;

BACTERIAL INFECTION; BLEEDING; BRAIN HEMORRHAGE; HUMAN; LUNG INJURY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA;

INTRAVENTRICULAR HAEMORRHAGE; NEONATOLOGY; PLATELET TRANSFUSION; THROMBOCYTOPENIA;

CEREBRAL HEMORRHAGE; COMORBIDITY; GUIDELINES AS TOPIC; HUMANS; INFANT, NEWBORN; PLATELET COUNT; PLATELET TRANSFUSION; RECEPTORS, THROMBOPOIETIN; RISK; THROMBOCYTOPENIA, NEONATAL ALLOIMMUNE;

EID: 84883490841     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/archdischild-2012-302535     Document Type: Review

References (31)

1. Christensen RD, Henry E, Wiedmeier SE, et al. Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system. J Perinatol 2006;26:348-53. (Pubitemid 43811510)
2. Baer VL, Lambert DK, Henry E, et al. Do platelet transfusions in the NICU adversely affect survival? Analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system. J Perinatol 2007;27:790-6. (Pubitemid 350176961)
3. Aster RH. Should total platelet mass be a criterion for prophylactic platelet transfusion? Transfusion 2009;49:2014-15.
4. Josephson CD, Su LL, Christensen RD, et al. Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. Pediatrics 2009;123:278-85.
5. Chaudhary R, Clarke P. Current transfusion practices for platelets and fresh, frozen plasma in UK tertiary level neonatal units. Acta Paediatr 2008;97:135.
6. British Committee for Standards in Haematology. Gibson BES (Chair), Todd A, Roberts I, et al. Transfusion guidelines for neonates and older children. Br J Haematol 2004;124:433-53.
7. Murray NA, Howarth LJ, McCloy MP, et al. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med 2002;12:35-41. (Pubitemid 34184944)
8. Borges JP, Dos Santos AM, da Cunha DH, et al. Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants. Vox Sang 2012. doi:10.1111/j.1423-0410.2012.01658.x. [Epub ahead of print].
9. Christensen RD. Platelet transfusion in the neonatal intensive care unit: benefits, risks, alternatives. Neonatology 2011;100:311-18.
10. Saxonhouse MA, Manco-Johnson MJ. The evaluation and management of neonatal coagulation disorders. Semin Perinatol 2009;33:52-65.
11. Stanworth SJ, Clarke P, Watts T, et al. Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics 2009;124:e826-e34.
12. Venkatesh V, Curley A, Khan R, et al . A novel approach to standardised recording of bleeding in a high risk neonatal population. Arch Dis Child Fetal Neonatal Ed 2012. [Epub ahead of print] doi:10.1136/archdischild-2012-302443
13. Muthukumar P, Venkatesh V, Curley A, et al. Severe thrombocytopenia and patterns of bleeding in neonates: results from a prospective observational study and implications for use of platelet transfusions. Transfus Med 2012;22:338-43.
14. Andrew M, Vegh P, Caco C, et al. A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants. J Pediatr 1993;123:285-91. (Pubitemid 23221114)
15. Stainsby D, Jones H, Wells AW, et al. Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996-2005. Br J Haematol 2008;141:73-9. (Pubitemid 351347538)
16. Gajic O, Rana R, Winters JL, et al. Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med 2007;176:886-91. (Pubitemid 350097078)
17. Rana R, Fernandez-Perez ER, Khan SA, et al. Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study. Transfusion 2006;46:1478-83. (Pubitemid 44326320)
18. Popovsky MA. Transfusion and the lung: circulatory overload and acute lung injury. Vox Sang 2004;87(Suppl 2):62-5.
19. Popovsky MA. Transfusion-associated circulatory overload: the plot thickens. Transfusion 2009;49:2-4.
20. Li G, Rachmale S, Kojicic M, et al. Incidence and transfusion risk factors for transfusion-associated circulatory overload among medical intensive care unit patients. Transfusion 2011;51:338-43.
21. Brecher ME, Blajchman MA, Yomtovian R, et al. Addressing the risk of bacterial contamination of platelets within the United States: a history to help illuminate the future. Transfusion 2013;53:221-31.
22. Kenton AB, O' Donovan D, Cass DL, et al. Severe thrombocytopenia predicts outcome in neonates with necrotizing enterocolitis. J Perinatol 2005;25:14-20. (Pubitemid 40207648)
23. Bussel JB, Zacharoulis S, Kramer K, et al. Clinical and diagnostic comparison of neonatal alloimmune thrombocytopenia to non-immune cases of thrombocytopenia. Pediatr Blood Cancer 2005;45:176-83. (Pubitemid 40993584)
24. Kiefel V, Bassler D, Kroll H, et al. Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT). Blood 2006;107:3761-3.
25. Bussel JB. Immune thrombocytopenia in pregnancy: autoimmune and alloimmune. J Reprod Immunol 1997;37:35-61. (Pubitemid 28052670)
26. Webert KE, Mittal R, Sigouin C, et al. A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura. Blood 2003;102:4306-11. (Pubitemid 37494088)
27. Bussel JB, Cheng G, Saleh MN, et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007;357:2237-47. (Pubitemid 350190754)
28. Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis- stimulating protein, for chronic ITP. N Engl J Med 2006;355:1672-81. (Pubitemid 44583957)
29. Bussel JB, Buchanan GR, Nugent DJ, et al. A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia. Blood 2011;118:28-36.
30. Sallmon H, Gutti RK, Ferrer-Marin F, et al. Increasing platelets without transfusion: is it time to introduce novel thrombopoietic agents in neonatal care? J Perinatol 2010;30:765-9.
31. Ehrenreich H, Hasselblatt M, Knerlich F, et al. A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Proc Natl Acad Sci USA 2005;102:862-7. (Pubitemid 40282756)